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Stock-based Compensation (Tables)

12 Months Ended

Dec. 31, 2012

Stock-based Compensation [Abstract]

Estimated weighted average grant date fair value per share

		Years Ended December 31,
		2012				2011
Expected term			5.3 years				5.8 years
Expected volatility			108	%			110	%
Risk-free interest rate			0.15	%			2.20	%
Expected dividend yield			0	%			0	%
Weighted-average grant date fair value per share		$	4.68			$	10.95

Summary of stock option activities

		For the years ended December 31,
		2012								2011
		# of Options				Weighted Average Exercise Price				# of Options				Weighted Average Exercise Price
Options outstanding, beginning of period			144,039			$	19.20				158,873			$	191.22
Granted			5,833				6.00				27,450				13.44
Exercised			—				0.00				(188	)			7.86
Forfeited and cancelled			(5,853	)			27.96				(42,096	)			664.86
Options outstanding, end of period			144,019			$	18.28				144,039			$	19.20
Options exercisable, end of period			125,666			$	18.77				102,691			$	20.10
Options vested and expected to vest			142,227			$	18.30

Summary of stock options outstanding and exercisable

								Options Outstanding												Options Exercisable
Range of Exercise Prices								Number Outstanding				Weighted Average Remaining Contractual Term (in years)				Weighted Average Exercise Price				Number Exercisable				Weighted Average Exercise Price
$0.36		—		$	3.60				1,248				2.42			$	3.13				1,248			$	3.13
5.40		—			5.40				33,844				1.20				5.40				33,844				5.40
6.00		—			11.16				22,078				5.19				9.73				21,883				9.76
13.44		—			13.44				25,363				7.87				13.44				14,115				13.44
16.14		—			17.40				26,354				5.91				16.96				20,386				17.09
17.82		—			33.42				34,570				5.55				27.85				33,628				27.95
87.47		—			1,908.00				562				3.43				856.14				562				856.14
									144,019				4.91			$	18.28				125,666			$	18.77

Non-cash, share-based compensation expense

		Years Ended December 31,								Period from December 17, 2001 (date of inception) to December 31, 2012
		2012				2011
Research and Development		$	94			$	117			$	590
Selling, General and Administrative			212				191				1,611
Restructuring Expense			—				—				387
Total		$	306			$	308			$	2,588

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Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed.

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Tabular disclosure of share-based compensation plans that may be presented in a single table for outstanding, vested and expected to vest, and exercisable awards. The information that may be disclosed in this table may include, but is not limited to, number of shares, weighted average exercise price, weighted average remaining contractual life, and aggregate intrinsic value.

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Tabular disclosure of option exercise prices, by grouped ranges, including the upper and lower limits of the price range, the number of shares under option, weighted average exercise price and remaining contractual option terms.

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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