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Consolidated Statements of Preferred Stock and Stockholders' Equity (Deficit) (USD $) In Thousands, except Share data	Total	Common Stock	Series A	Series B	Additional Paid In Capital	Deficit Accumulated During Development Stage	Accretion of Series A	Accretion of Series A Common Stock	Accretion of Series A Series A	Accretion of Series A Series B	Accretion of Series A Additional Paid In Capital	Accretion of Series A Deficit Accumulated During Development Stage	Accretion of Series B	Accretion of Series B Common Stock	Accretion of Series B Series A	Accretion of Series B Series B	Accretion of Series B Additional Paid In Capital	Accretion of Series B Deficit Accumulated During Development Stage	Common Conversion	Common Conversion Common Stock	Common Conversion Series A	Common Conversion Series B	Common Conversion Additional Paid In Capital	Common Conversion Deficit Accumulated During Development Stage	Notes and Related Accrued Interest	Notes and Related Accrued Interest Common Stock	Notes and Related Accrued Interest Series A	Notes and Related Accrued Interest Series B	Notes and Related Accrued Interest Additional Paid In Capital	Notes and Related Accrued Interest Deficit Accumulated During Development Stage	Cash, Net of Offering Costs	Cash, Net of Offering Costs Common Stock	Cash, Net of Offering Costs Series A	Cash, Net of Offering Costs Series B	Cash, Net of Offering Costs Additional Paid In Capital	Cash, Net of Offering Costs Deficit Accumulated During Development Stage	Issuance of Series A on February 22, 2006	Issuance of Series A on February 22, 2006 Common Stock	Issuance of Series A on February 22, 2006 Series A	Issuance of Series A on February 22, 2006 Series B	Issuance of Series A on February 22, 2006 Additional Paid In Capital	Issuance of Series A on February 22, 2006 Deficit Accumulated During Development Stage	Issuance of Series A on December 8, 2006	Issuance of Series A on December 8, 2006 Common Stock	Issuance of Series A on December 8, 2006 Series A	Issuance of Series A on December 8, 2006 Series B	Issuance of Series A on December 8, 2006 Additional Paid In Capital	Issuance of Series A on December 8, 2006 Deficit Accumulated During Development Stage	Issuance for Notes Payable and Related Accrued Interest on January 3, 2005 Common Stock	Issuance for Notes Payable and Related Accrued Interest on January 3, 2005 Series A	Issuance for Notes Payable and Related Accrued Interest on January 3, 2005 Series B	Issuance for Notes Payable and Related Accrued Interest on January 3, 2005 Additional Paid In Capital	Issuance for Notes Payable and Related Accrued Interest on January 3, 2005 Deficit Accumulated During Development Stage	Issuance for Notes Payable and Related Accrued Interest on October 14, 2005	Issuance for Notes Payable and Related Accrued Interest on October 14, 2005 Common Stock	Issuance for Notes Payable and Related Accrued Interest on October 14, 2005 Series A	Issuance for Notes Payable and Related Accrued Interest on October 14, 2005 Series B	Issuance for Notes Payable and Related Accrued Interest on October 14, 2005 Additional Paid In Capital	Issuance for Notes Payable and Related Accrued Interest on October 14, 2005 Deficit Accumulated During Development Stage	Issuance for Notes Payable and Related Accrued Interest on February 22, 2006	Issuance for Notes Payable and Related Accrued Interest on February 22, 2006 Common Stock	Issuance for Notes Payable and Related Accrued Interest on February 22, 2006 Series A	Issuance for Notes Payable and Related Accrued Interest on February 22, 2006 Series B	Issuance for Notes Payable and Related Accrued Interest on February 22, 2006 Additional Paid In Capital	Issuance for Notes Payable and Related Accrued Interest on February 22, 2006 Deficit Accumulated During Development Stage	Issuance for Intellectual Property License Rights on October 14, 2005	Issuance for Intellectual Property License Rights on October 14, 2005 Common Stock	Issuance for Intellectual Property License Rights on October 14, 2005 Series A	Issuance for Intellectual Property License Rights on October 14, 2005 Series B	Issuance for Intellectual Property License Rights on October 14, 2005 Additional Paid In Capital	Issuance for Intellectual Property License Rights on October 14, 2005 Deficit Accumulated During Development Stage	Issuance for Intellectual Property License Rights on February 21, 2006	Issuance for Intellectual Property License Rights on February 21, 2006 Common Stock	Issuance for Intellectual Property License Rights on February 21, 2006 Series A	Issuance for Intellectual Property License Rights on February 21, 2006 Series B	Issuance for Intellectual Property License Rights on February 21, 2006 Additional Paid In Capital	Issuance for Intellectual Property License Rights on February 21, 2006 Deficit Accumulated During Development Stage	Issuance for Intellectual Property License Rights on February 22, 2006	Issuance for Intellectual Property License Rights on February 22, 2006 Common Stock	Issuance for Intellectual Property License Rights on February 22, 2006 Series A	Issuance for Intellectual Property License Rights on February 22, 2006 Series B	Issuance for Intellectual Property License Rights on February 22, 2006 Additional Paid In Capital	Issuance for Intellectual Property License Rights on February 22, 2006 Deficit Accumulated During Development Stage	Issuance for Intellectual Property License Rights on June 23, 2006	Issuance for Intellectual Property License Rights on June 23, 2006 Common Stock	Issuance for Intellectual Property License Rights on June 23, 2006 Series A	Issuance for Intellectual Property License Rights on June 23, 2006 Series B	Issuance for Intellectual Property License Rights on June 23, 2006 Additional Paid In Capital	Issuance for Intellectual Property License Rights on June 23, 2006 Deficit Accumulated During Development Stage	Issuance for Intellectual Property License Rights on November 7, 2006	Issuance for Intellectual Property License Rights on November 7, 2006 Common Stock	Issuance for Intellectual Property License Rights on November 7, 2006 Series A	Issuance for Intellectual Property License Rights on November 7, 2006 Series B	Issuance for Intellectual Property License Rights on November 7, 2006 Additional Paid In Capital	Issuance for Intellectual Property License Rights on November 7, 2006 Deficit Accumulated During Development Stage	Issuance for Intellectual Property License Rights on January 18, 2007	Issuance for Intellectual Property License Rights on January 18, 2007 Common Stock	Issuance for Intellectual Property License Rights on January 18, 2007 Series A	Issuance for Intellectual Property License Rights on January 18, 2007 Series B	Issuance for Intellectual Property License Rights on January 18, 2007 Additional Paid In Capital	Issuance for Intellectual Property License Rights on January 18, 2007 Deficit Accumulated During Development Stage	Issuance for Intellectual Property License Rights on June 30, 2007	Issuance for Intellectual Property License Rights on June 30, 2007 Common Stock	Issuance for Intellectual Property License Rights on June 30, 2007 Series A	Issuance for Intellectual Property License Rights on June 30, 2007 Series B	Issuance for Intellectual Property License Rights on June 30, 2007 Additional Paid In Capital	Issuance for Intellectual Property License Rights on June 30, 2007 Deficit Accumulated During Development Stage	Issuance for Series B on May 31, 2007	Issuance for Series B on May 31, 2007 Common Stock	Issuance for Series B on May 31, 2007 Series A	Issuance for Series B on May 31, 2007 Series B	Issuance for Series B on May 31, 2007 Additional Paid In Capital	Issuance for Series B on May 31, 2007 Deficit Accumulated During Development Stage	Issuance for Series B on December 28, 2007	Issuance for Series B on December 28, 2007 Common Stock	Issuance for Series B on December 28, 2007 Series A	Issuance for Series B on December 28, 2007 Series B	Issuance for Series B on December 28, 2007 Additional Paid In Capital	Issuance for Series B on December 28, 2007 Deficit Accumulated During Development Stage	Issuance of Common Stock for Commercial License Rights, on July 19, 2007	Issuance of Common Stock for Commercial License Rights, on July 19, 2007 Common Stock	Issuance of Common Stock for Commercial License Rights, on July 19, 2007 Series A	Issuance of Common Stock for Commercial License Rights, on July 19, 2007 Series B	Issuance of Common Stock for Commercial License Rights, on July 19, 2007 Additional Paid In Capital	Issuance of Common Stock for Commercial License Rights, on July 19, 2007 Deficit Accumulated During Development Stage	Issuance of Shares to Executive Subject to Repurchase	Issuance of Shares to Executive Subject to Repurchase Common Stock	Issuance of Shares to Executive Subject to Repurchase Series A	Issuance of Shares to Executive Subject to Repurchase Series B	Issuance of Shares to Executive Subject to Repurchase Additional Paid In Capital	Issuance of Shares to Executive Subject to Repurchase Deficit Accumulated During Development Stage	Series A offering costs	Series A offering costs Common Stock	Series A offering costs Series A	Series A offering costs Series B	Series A offering costs Additional Paid In Capital	Series A offering costs Deficit Accumulated During Development Stage
Beginning Balance, value at Dec. 17, 2001
Issuance of common stock for cash, net of offering costs, value	$ 1				$ 1
Issuance of common stock for cash, net of offering costs, shares		2,588
Net loss	(116)					(116)
Ending Balance, value at Dec. 31, 2003	(115)				1	(116)
Ending Balance, shares at Dec. 31, 2003		2,588
Issuance of common stock for cash, net of offering costs, value	7				7
Issuance of common stock for cash, net of offering costs, shares																																19,720
Net loss	(511)					(511)
Ending Balance, value at Dec. 31, 2004	(619)				8	(627)
Ending Balance, shares at Dec. 31, 2004		22,308
Issuance of common stock for cash, net of offering costs, value	1																														1				1																	1		1,354				1,354								44				44
Issuance of common stock for cash, net of offering costs, shares		2,922																																															2,978						31,095												903
Net loss	(1,459)					(1,459)
Ending Balance, value at Dec. 31, 2005	(678)				1,408	(2,086)
Ending Balance, shares at Dec. 31, 2005		60,206
Offering Costs	(17)		17		(17)																																																																																																																																	(98)
Issuance of common stock for cash, net of offering costs, value																																							9,316						5,000																											75				75		60				60		15				15
Issuance of common stock for cash, net of offering costs, shares																																							5,727,354						3,074,086																												17,372						13,907						2,505						38
Issuance of common stock upon exercise of stock options, for cash, value	3				3																																																									684
Issuance of common stock upon exercise of stock options, for cash, shares		8,019																																																												420,817
Share-based compensation	39				39
Net loss	(5,241)					(5,241)
Ending Balance, value at Dec. 31, 2006	(5,744)		14,919		1,583	(7,327)
Ending Balance, shares at Dec. 31, 2006		102,047	9,222,257
Offering Costs				(147)			(19)		19		(19)		(18)			18	(18)
Issuance of common stock for cash, net of offering costs, value																																																																																																13				13		7				7					9,000						9,000
Issuance of common stock for cash, net of offering costs, shares																																																																																																	1,303						642								3,688,902						2,766,677				2,783						13,915
Issuance of common stock upon exercise of stock options, for cash, value	16				16
Issuance of common stock upon exercise of stock options, for cash, shares		2,227
Share-based compensation	50				50
Net loss	(13,994)					(13,994)
Ending Balance, value at Dec. 31, 2007	(19,689)		14,938	17,871	1,632	(21,321)
Ending Balance, shares at Dec. 31, 2007		122,917	9,222,257	6,455,579
Estimated fair value of warrants issued in connection with convertible notes payable	399				399
Offering Costs							(20)		20		(20)		(36)			36	(36)
Issuance of common stock upon exercise of stock options, for cash, value	54				54
Issuance of common stock upon exercise of stock options, for cash, shares		36,154
Share-based compensation	545				545
Net loss	(19,431)					(19,431)
Ending Balance, value at Dec. 31, 2008	(38,178)		14,958	17,907	2,574	(40,752)
Ending Balance, shares at Dec. 31, 2008		159,071	9,222,257	6,455,579
Deemed preferred stock dividend for additional common shares issuable under anti-dilution provision	(781)			781	(781)
Offering Costs							(42)		42		(42)		(93)			93	(93)
Conversion of preferred stock and convertible notes and related accrued interest, value																			33,781	1	(15,000)	(18,781)	33,780		8,501				8,501
Conversion of preferred stock, shares																				507,123	(9,222,257)	(6,455,579)
Restricted stock release from restriction	75				75
Shares of common stock purchased																										145,465
Conversion of warrants for preferred stock	36				36
Merger with Nuvelo, Inc., value	11,913				11,913
Merger with Nuvelo, Inc., shares		447,826
Adjustment for fractional shares		(102)																		(7)
Issuance of common stock upon exercise of stock options, for cash, value	114				114
Issuance of common stock upon exercise of stock options, for cash, shares		10,521
Share-based compensation	845				845
Issuance of common stock under employee stock purchase plan and upon vesting of restricted stock units, value	2				2
Issuance of common stock under employee stock purchase plan and upon vesting of restricted stock units, shares		177
Estimated fair value of warrants issued in connection with lease termination	377				377
Net loss	(9,138)					(9,138)
Ending Balance, value at Dec. 31, 2009	7,412	1			57,301	(49,890)
Ending Balance, shares at Dec. 31, 2009		1,270,074
Issuance of common stock for cash, net of offering costs, value																															7,182				7,182
Issuance of common stock for cash, net of offering costs, shares																																194,100
Issuance of common stock upon exercise of stock options, for cash, value	139				139
Issuance of common stock upon exercise of stock options, for cash, shares		8,248
Share-based compensation	458				458
Net loss	(8,420)					(8,420)
Ending Balance, value at Dec. 31, 2010	6,771	1			65,080	(58,310)
Ending Balance, shares at Dec. 31, 2010		1,472,422
Issuance of common stock for cash, net of offering costs, value																															4,017	1			4,016
Issuance of common stock for cash, net of offering costs, shares																																557,890
Issuance of common stock upon exercise of stock options, for cash, value
Issuance of common stock upon exercise of stock options, for cash, shares	188	188
Share-based compensation	308				308
Net loss	(5,364)					(5,364)
Ending Balance, value at Dec. 31, 2011	5,732	2			69,404	(63,674)
Ending Balance, shares at Dec. 31, 2011		2,030,500
Issuance of common stock for cash, net of offering costs, value																															1,189	1			1,188
Issuance of common stock for cash, net of offering costs, shares																																629,815
Issuance of common stock upon exercise of stock options, for cash, value
Issuance of common stock upon exercise of stock options, for cash, shares
Share-based compensation	306				306
Net loss	(4,320)					(4,320)
Ending Balance, value at Dec. 31, 2012	$ 2,907	$ 3			$ 70,898	$ (67,994)
Ending Balance, shares at Dec. 31, 2012		2,660,315

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