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Share-based Compensation (Tables) | 9 Months Ended
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Sep. 30, 2013
Non-cash, Share-Based Compensation Expense | For the three and nine month periods ended September 30, 2013 and 2012 and for the period from Inception through September 30, 2013, the Company recognized the following non-cash, share-based compensation expense in the consolidated statement of operations (in thousands):
| Three Months Ended September 30, |  |  | Nine Months Ended September 30, |  |  | Period from December 17, 2001 (date of inception) to September 30, 2013 |
--- | --- | --- | --- | --- | --- | --- | --- | ---
| 2013 |  |  | 2012 |  |  | 2013 |  |  | 2012 |  |
Research and Development | $ |  | 7 |  |  | $ |  | 25 |  |  | $ |  | 36 |  |  | $ |  | 76 |  |  | $ |  | 626 |
Selling, General and Administrative |  | 42 |  |  |  | 49 |  |  |  | 89 |  |  |  | 167 |  |  |  | 1,700 |
Restructuring Expense |  | — |  |  |  | — |  |  |  | — |  |  |  | — |  |  |  | 387 |
Total | $ |  | 49 |  |  | $ |  | 74 |  |  | $ |  | 125 |  |  | $ |  | 243 |  |  | $ |  | 2,713 |
Summary of Stock Option Activities | Stock option transactions for the nine month period ended September 30, 2013 under all plans are as follows:
| # of Options |  |  | Weighted Average Exercise Price |  |  | Weighted Average Remaining Contractual Term (in years) |
--- | --- | --- | --- | --- | --- | --- | --- | ---
Options outstanding at December 31, 2012 |  | 144,019 |  |  | $ |  | 18.28 |  |  |  | 4.91 |
Changes during the period: |  |  |  |  |  |  |  |  |  |  |
Granted |  | 731,535 |  |  |  | 1.38 |  |  |  |  |
Exercised |  | — |  |  |  | — |  |  |  |  |
Forfeited, cancelled or expired |  | (39,113 | ) |  |  | 11.07 |  |  |  |  |
Options outstanding at September 30, 2013 |  | 836,441 |  |  | $ |  | 3.84 |  |  |  | 9.39 |
Options exercisable at September 30, 2013 |  | 115,435 |  |  | $ |  | 18.08 |  |  |  | 6.12 |
Options vested and expected to vest |  | 721,216 |  |  | $ |  | 4.20 |  |  |  | 9.31 |

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- Definition Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5047-113901 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB TOPIC 14.F) -URI http://asc.fasb.org/extlink&oid=27013229&loc=d3e301413-122809 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Staff Accounting Bulletin (SAB) -Number Topic 14 -Section F Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of share-based compensation plans that may be presented in a single table for outstanding, vested and expected to vest, and exercisable awards. The information that may be disclosed in this table may include, but is not limited to, number of shares, weighted average exercise price, weighted average remaining contractual life, and aggregate intrinsic value. + References No definition available. + Details
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