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Share-based Compensation (Details 1) (USD $)
 9 Months Ended 12 Months Ended
Sep. 30, 2013
Dec. 31, 2012
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]    
Options outstanding beginning of period 144,019  
Number of Options, Granted 731,535  
Issuance of common stock upon exercise of stock options, for cash, shares      
Number of Options Forfeited, cancelled or expired 39,113  
Options outstanding end of the period 836,441 144,019
Options exercisable, end of period, Number of Options 115,435  
Options vested and expected to vest, Number of Options 721,216  
Weighted Average exercise Price, Options Outstanding, Beginning of period $ 18.28  
Weighted average exercise price, Granted $ 1.38  
Weighted average exercise price, Exercised     
Weighted average exercise price, Forfeited, cancelled or expired $ 11.07  
Weighted Average exercise Price, Options Outstanding, end of period $ 3.84 $ 18.28
Weighted average exercise price, Options exercisable, end of period $ 18.08  
Weighted Average exercise Price, Options vested and expected to vest, end of period $ 4.20  
Weighted Average Remaining Contractual Term (in years) Options Outstanding 9 years 4 months 21 days 4 years 10 months 28 days
Options exercisable at September 30, 2013, Weighted Average Remaining Contractual Term (in years) 6 years 1 month 13 days  
Options vested and expected to vest, Weighted Average Remaining Contractual Term (in years) 9 years 3 months 22 days