<SEC-DOCUMENT>0001193125-13-164068.txt : 20130422
<SEC-HEADER>0001193125-13-164068.hdr.sgml : 20130422
<ACCEPTANCE-DATETIME>20130422090120
ACCESSION NUMBER:		0001193125-13-164068
CONFORMED SUBMISSION TYPE:	8-K
PUBLIC DOCUMENT COUNT:		4
CONFORMED PERIOD OF REPORT:	20130418
ITEM INFORMATION:		Entry into a Material Definitive Agreement
ITEM INFORMATION:		Financial Statements and Exhibits
FILED AS OF DATE:		20130422
DATE AS OF CHANGE:		20130422

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ARCA biopharma, Inc.
		CENTRAL INDEX KEY:			0000907654
		STANDARD INDUSTRIAL CLASSIFICATION:	IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES [2835]
		IRS NUMBER:				363855489
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		8-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-22873
		FILM NUMBER:		13772775

	BUSINESS ADDRESS:	
		STREET 1:		8001 ARISTA PLACE
		STREET 2:		SUITE 200
		CITY:			BROOMFIELD
		STATE:			CO
		ZIP:			80021
		BUSINESS PHONE:		720-940-2200

	MAIL ADDRESS:	
		STREET 1:		8001 ARISTA PLACE
		STREET 2:		SUITE 200
		CITY:			BROOMFIELD
		STATE:			CO
		ZIP:			80021

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	NUVELO INC
		DATE OF NAME CHANGE:	20030203

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	HYSEQ INC
		DATE OF NAME CHANGE:	19970610
</SEC-HEADER>
<DOCUMENT>
<TYPE>8-K
<SEQUENCE>1
<FILENAME>d526054d8k.htm
<DESCRIPTION>FORM 8-K
<TEXT>
<HTML><HEAD>
<TITLE>Form 8-K</TITLE>
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 <P STYLE="line-height:0px;margin-top:0px;margin-bottom:0px;border-bottom:0.5pt solid #000000">&nbsp;</P>
<P STYLE="line-height:3px;margin-top:0px;margin-bottom:2px;border-bottom:0.5pt solid #000000">&nbsp;</P> <P STYLE="margin-top:4px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="5"><B>UNITED STATES </B></FONT></P>
<P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="5"><B>SECURITIES AND EXCHANGE COMMISSION </B></FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT
STYLE="font-family:Times New Roman" SIZE="3"><B>WASHINGTON, D.C. 20549 </B></FONT></P> <P STYLE="font-size:12px;margin-top:0px;margin-bottom:0px">&nbsp;</P><center>
<P STYLE="line-height:6px;margin-top:0px;margin-bottom:2px;border-bottom:1pt solid #000000;width:21%">&nbsp;</P></center> <P STYLE="margin-top:12px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="5"><B>FORM 8-K
</B></FONT></P> <P STYLE="font-size:12px;margin-top:0px;margin-bottom:0px">&nbsp;</P><center> <P STYLE="line-height:6px;margin-top:0px;margin-bottom:2px;border-bottom:1pt solid #000000;width:21%">&nbsp;</P></center>
<P STYLE="margin-top:12px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="4"><B>CURRENT REPORT </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px" ALIGN="center"><FONT
STYLE="font-family:Times New Roman" SIZE="3"><B>Pursuant to Section&nbsp;13 or 15(d) of </B></FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="3"><B>the Securities Exchange Act of
1934 </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="3"><B>Date of Report (Date of Earliest Event Reported): April&nbsp;22, 2013 (April 18, 2013) </B></FONT></P>
<P STYLE="font-size:12px;margin-top:0px;margin-bottom:0px">&nbsp;</P><center> <P STYLE="line-height:6px;margin-top:0px;margin-bottom:2px;border-bottom:1pt solid #000000;width:21%">&nbsp;</P></center>
<P STYLE="margin-top:12px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="6"><B>ARCA biopharma, Inc. </B></FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(Exact Name of Registrant as Specified in Charter) </B></FONT></P> <P STYLE="font-size:12px;margin-top:0px;margin-bottom:0px">&nbsp;</P><center>
<P STYLE="line-height:6px;margin-top:0px;margin-bottom:2px;border-bottom:1pt solid #000000;width:21%">&nbsp;</P></center> <P STYLE="font-size:12px;margin-top:0px;margin-bottom:0px">&nbsp;</P>
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<TD VALIGN="top" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Delaware</B></FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="top" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>000-22873</B></FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="top" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>36-3855489</B></FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="1"><B>(State or Other Jurisdiction</B></FONT></P> <P STYLE="margin-top:0px;margin-bottom:1px" ALIGN="center"><FONT
STYLE="font-family:Times New Roman" SIZE="1"><B>of Incorporation)</B></FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="1"><B>(Commission</B></FONT></P> <P STYLE="margin-top:0px;margin-bottom:1px" ALIGN="center"><FONT
STYLE="font-family:Times New Roman" SIZE="1"><B>File Number)</B></FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="1"><B>(I.R.S. Employer</B></FONT></P> <P STYLE="margin-top:0px;margin-bottom:1px" ALIGN="center"><FONT
STYLE="font-family:Times New Roman" SIZE="1"><B>Identification No.)</B></FONT></P></TD></TR>
</TABLE> <P STYLE="margin-top:12px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>8001 Arista Place, Suite 430, Broomfield, CO 80021 </B></FONT></P>
<P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="1"><B>(Address of Principal Executive Offices) (Zip Code) </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px" ALIGN="center"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(720) 940-2200 </B></FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="1"><B>(Registrant&#146;s Telephone Number, Including Area Code)
</B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Not Applicable </B></FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT
STYLE="font-family:Times New Roman" SIZE="1"><B>(Former Name or Former Address, if Changed Since Last Report) </B></FONT></P> <P STYLE="font-size:12px;margin-top:0px;margin-bottom:0px">&nbsp;</P><center>
<P STYLE="line-height:6px;margin-top:0px;margin-bottom:2px;border-bottom:1pt solid #000000;width:21%">&nbsp;</P></center> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">Check the appropriate box below
if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below): </FONT></P>
<P STYLE="font-size:6px;margin-top:0px;margin-bottom:0px">&nbsp;</P>
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<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT STYLE="font-family:Times New Roman" SIZE="2"><FONT STYLE="FONT-FAMILY:WINGDINGS">&#168;</FONT></FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425) </FONT></TD></TR></TABLE>
<P STYLE="font-size:6px;margin-top:0px;margin-bottom:0px">&nbsp;</P>
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<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT STYLE="font-family:Times New Roman" SIZE="2"><FONT STYLE="FONT-FAMILY:WINGDINGS">&#168;</FONT></FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) </FONT></TD></TR></TABLE>
<P STYLE="font-size:6px;margin-top:0px;margin-bottom:0px">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
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<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT STYLE="font-family:Times New Roman" SIZE="2"><FONT STYLE="FONT-FAMILY:WINGDINGS">&#168;</FONT></FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) </FONT></TD></TR></TABLE>
<P STYLE="font-size:6px;margin-top:0px;margin-bottom:0px">&nbsp;</P>
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<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT STYLE="font-family:Times New Roman" SIZE="2"><FONT STYLE="FONT-FAMILY:WINGDINGS">&#168;</FONT></FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) </FONT></TD></TR></TABLE>
<P STYLE="font-size:8px;margin-top:0px;margin-bottom:0px">&nbsp;</P> <P STYLE="line-height:0px;margin-top:0px;margin-bottom:0px;border-bottom:0.5pt solid #000000">&nbsp;</P>
<P STYLE="line-height:3px;margin-top:0px;margin-bottom:2px;border-bottom:0.5pt solid #000000">&nbsp;</P>

<p Style='page-break-before:always'>
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 <P STYLE="margin-top:0px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Item&nbsp;1.01 Entry into a Material Definitive Agreement </B></FONT></P>
<P STYLE="margin-top:6px;margin-bottom:0px; text-indent:4%;padding-bottom:0px; "><FONT STYLE="font-family:Times New Roman" SIZE="2">On April&nbsp;18, 2013, ARCA biopharma, Inc. (&#147;ARCA&#148;) entered into a Clinical Trial Collaboration Agreement
(the &#147;Agreement&#148;) with Medtronic, Inc. (&#147;Medtronic&#148;) to collaborate on ARCA&#146;s proposed clinical trial, known as GENETIC-AF, of its lead development drug, Gencaro&#153; (bucindolol hydrochloride). GENETIC-AF is planned as a
Phase 2b/3 clinical trial comparing Gencaro to metoprolol CR/XL for prevention of atrial fibrillation (&#147;AF&#148;) in patients with heart failure and reduced left ventricular ejection fraction. Under the Agreement, ARCA plans, with the support
of Medtronic, to conduct a substudy that will include continuous monitoring of the cardiac rhythms of all 200 patients enrolled during the Phase 2b portion of GENETIC-AF. Each patient will have heart rhythm monitoring via a Medtronic device, either
a previously implanted cardiac resynchronization or defibrillation device, or a previously or newly inserted
Reveal<FONT STYLE="font-family:Times New Roman" SIZE="1"><SUP STYLE="vertical-align:baseline; position:relative; bottom:.8ex">&reg;</SUP></FONT> loop recorder. The collaboration substudy will measure AF burden, defined as a patient&#146;s actual
time in AF regardless of symptoms. In determining the presence of an efficacy signal in the Phase 2b portion of the trial, AF burden will be evaluated along with time to mortality or recurrent AF, which will also be the Phase 3 primary endpoint.
</FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">The collaboration will be administered by a joint ARCA-Medtronic committee. Medtronic will use its proprietary CareLink
System to collect and analyze the cardiac rhythm data from the implanted Medtronic devices and provide the data to ARCA at the close of Phase 2b portion of the trial. The parties will negotiate in good faith to agree on the substudy protocol,
specifying the elements of the substudy and of the cardiac rhythm data collection and analysis to be provided for the substudy by Medtronic by August&nbsp;15, 2013. Medtronic will support the reimbursement process for patients enrolled in the Phase
2b portion, and will provide financial support of unreimbursed costs for a certain number of patients in the Phase 2B portion, and up to a certain maximum amount per patient. If GENETIC-AF proceeds to Phase 3, ARCA will seek to enroll an additional
100 patients in the substudy, and Medtronic will provide the agreed-on CareLink System cardiac rhythm data collection and analysis for the Phase 3 portion of the substudy, and support the reimbursement process. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">The Agreement may be terminated by Medtronic for various reasons including uncured material breach, an ARCA bankruptcy, if, after FDA
communication, it is reasonably concluded that the FDA will not allow GENETIC-AF to enroll or proceed, if the trial has not begun by December&nbsp;1, 2014, if the substudy protocol is not agreed-to by August&nbsp;15, 2013, or if Medtronic&#146;s
obligations are unilaterally expanded. ARCA may terminate the Agreement for various reasons, including uncured material breach, a Medtronic bankruptcy, if a claim is made that Medtronic&#146;s performance infringes third party rights, if ARCA
determines it cannot enroll or continue GENETIC-AF, or if the substudy protocol is not agreed to by August&nbsp;15, 2013. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">The
foregoing summary is qualified in its entirety by reference to the Agreement, a copy of which is filed as Exhibit 10.1 to this Current Report on Form 8-K, and which is incorporated herein by this reference. Certain portions of the Agreement have
been omitted and are subject to a FOIA Confidential Treatment Request to the Securities and Exchange Commission pursuant to Rule&nbsp;24b-2 under the Securities Exchange Act of 1934, as amended, which has been submitted on the date hereof. The
omitted material will be included in the request for confidential treatment. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">A press release announcing the Agreement is also
attached as Exhibit 99.1 hereto, the contents of which are incorporated herein by reference. </FONT></P> <P STYLE="margin-top:18px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Item&nbsp;9.01 Financial Statements and
Exhibits </B></FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">(d) Exhibits </FONT></P> <P STYLE="font-size:12px;margin-top:0px;margin-bottom:0px">&nbsp;</P>
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<TD VALIGN="bottom" NOWRAP> <P STYLE="border-bottom:1px solid #000000;width:39pt"><FONT STYLE="font-family:Times New Roman" SIZE="1"><B>Exhibit&nbsp;No.</B></FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="border-bottom:1px solid #000000"> <P STYLE="margin-top:0px;margin-bottom:1px"><FONT STYLE="font-family:Times New Roman" SIZE="1"><B>Description</B></FONT></P></TD></TR>


<TR>
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD></TR>
<TR>
<TD VALIGN="top" NOWRAP><FONT STYLE="font-family:Times New Roman" SIZE="2">10.1*</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Clinical Trial Collaboration Agreement between ARCA biopharma, Inc. and Medtronic, Inc. dated as of April&nbsp;18, 2013.</FONT></TD></TR>
<TR>
<TD HEIGHT="8"></TD>
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<TD VALIGN="top" NOWRAP><FONT STYLE="font-family:Times New Roman" SIZE="2">99.1</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Press Release titled &#147;ARCA Biopharma And Medtronic To Collaborate On Atrial Fibrillation Clinical Trial for Gencaro&#153;,&#148; dated April&nbsp;22, 2013.</FONT></TD></TR>
</TABLE> <P STYLE="font-size:12px;margin-top:0px;margin-bottom:0px">&nbsp;</P>
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<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT STYLE="font-family:Times New Roman" SIZE="2">*</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Confidential treatment has been requested with respect to certain portions of this exhibit. This exhibit omits the information subject to this confidentiality request.
Omitted portions have been filed separately with the SEC. </FONT></TD></TR></TABLE>

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 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>SIGNATURES </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT
STYLE="font-family:Times New Roman" SIZE="2">Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">Dated: April&nbsp;22, 2013 </FONT></P> <P STYLE="font-size:12px;margin-top:0px;margin-bottom:0px">&nbsp;</P><DIV ALIGN="right">
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<TD VALIGN="bottom" COLSPAN="3" NOWRAP> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>ARCA biopharma, Inc.</B></FONT></P> <P STYLE="margin-top:0px;margin-bottom:1px"><FONT
STYLE="font-family:Times New Roman" SIZE="2">(Registrant)</FONT></P></TD></TR>


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<TD VALIGN="top"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">By:</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"><FONT STYLE="font-family:Times New Roman" SIZE="2">/s/ Christopher D. Ozeroff</FONT></TD></TR>
<TR STYLE="font-size:1px">
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"> <P STYLE="border-top:1px solid #000000">&nbsp;</P></TD></TR>
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<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"><FONT STYLE="font-family:Times New Roman" SIZE="2">Name: Christopher D. Ozeroff</FONT></TD></TR>
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<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"><FONT STYLE="font-family:Times New Roman" SIZE="2">Title:&nbsp;Senior&nbsp;Vice&nbsp;President&nbsp;and&nbsp;General&nbsp;Counsel</FONT></TD></TR>
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 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>EXHIBIT INDEX </B></FONT></P>
<P STYLE="font-size:12px;margin-top:0px;margin-bottom:0px">&nbsp;</P>
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<TD VALIGN="bottom" NOWRAP> <P STYLE="border-bottom:1px solid #000000;width:39pt"><FONT STYLE="font-family:Times New Roman" SIZE="1"><B>Exhibit&nbsp;No.</B></FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="border-bottom:1px solid #000000"> <P STYLE="margin-top:0px;margin-bottom:1px"><FONT STYLE="font-family:Times New Roman" SIZE="1"><B>Description</B></FONT></P></TD></TR>


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<TD VALIGN="top" NOWRAP><FONT STYLE="font-family:Times New Roman" SIZE="2">10.1*</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Clinical Trial Collaboration Agreement between ARCA biopharma, Inc. and Medtronic, Inc. dated as of April&nbsp;18, 2013.</FONT></TD></TR>
<TR>
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD></TR>
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<TD VALIGN="top" NOWRAP><FONT STYLE="font-family:Times New Roman" SIZE="2">99.1</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Press Release titled &#147;ARCA Biopharma And Medtronic To Collaborate On Atrial Fibrillation Clinical Trial for Gencaro&#153;,&#148; dated April&nbsp;22, 2013.</FONT></TD></TR>
</TABLE> <P STYLE="font-size:12px;margin-top:0px;margin-bottom:0px">&nbsp;</P>
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<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT STYLE="font-family:Times New Roman" SIZE="2">*</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Confidential treatment has been requested with respect to certain portions of this exhibit. This exhibit omits the information subject to this confidentiality request.
Omitted portions have been filed separately with the SEC. </FONT></TD></TR></TABLE>
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 <P STYLE="margin-top:0px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>[ * ] = Certain confidential information contained in this document, marked by brackets, is filed with
the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. </B></FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Exhibit 10.1 </B></FONT></P> <P STYLE="margin-top:24px;margin-bottom:0px" ALIGN="center"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>CLINICAL TRIAL COLLABORATION AGREEMENT </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">This Clinical Trial Collaboration
Agreement (this &#147;<B>Agreement</B>&#148;) is made and entered into as of April&nbsp;18, 2013 (the &#147;<B>Effective Date</B>&#148;) between ARCA biopharma, Inc., a Delaware corporation (hereinafter <B>&#147;ARCA&#148;</B>), and Medtronic, Inc.,
a Delaware corporation (hereinafter <B>&#147;Medtronic&#148;</B>). </FONT></P> <P STYLE="margin-top:24px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>INTRODUCTION </B></FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>A. </B>ARCA is a drug development company, with capabilities related to the clinical development of cardiovascular drugs, the efficacy
and safety of which for patients may be improved through the use of genetic biomarkers. <B> </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>B. </B>ARCA is developing
the Drug Product and is planning to conduct the GENETIC-AF Trial as the next clinical study of the Drug Product, which will include the Phase 2B Study (as such terms are hereinafter defined).<B> </B></FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>C. </B>Medtronic is a leader in the field of developing and commercializing medical device technology, including the Reveal device, as
hereinafter defined.<B> </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>D. </B>ARCA desires to collaborate with Medtronic and utilize Medtronic&#146;s capabilities in
cardiac monitoring and analysis, including use of the Reveal device in the Phase 2B Study, and Medtronic is interested in obtaining additional clinical cardiac monitoring data, including data on the use of the Reveal device in the Phase 2B Study;<B>
</B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">NOW, THEREFORE, in consideration of the foregoing premises and the mutual covenants contained herein, and other good and
valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the parties hereby agree as follows: </FONT></P>
<P STYLE="margin-top:24px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>ARTICLE I </B></FONT></P>
<P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>DEFINITIONS </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT
STYLE="font-family:Times New Roman" SIZE="2">In addition to terms defined elsewhere in this Agreement, for purposes of this Agreement, the terms defined in this Article I shall have the following meanings. Definitions are not dependent on whether a
defined term is used in its singular or plural form. Use of the singular includes the plural and vice versa, unless the context requires otherwise. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>&#147;Act&#148;</B> means the U.S. Food, Drug and Cosmetic Act, as amended, 21 U.S.C. 301 et. seq., and the regulations promulgated thereunder. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>&#147;AF Burden&#148;</B> means the amount of time the heart is in atrial fibrillation, regardless of whether the patient is
symptomatic. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>&#147;Affiliate&#148;</B> means, with respect to any Party, any corporation or other entity that, directly or
indirectly, by itself or through one or more intermediaries, controls, or is controlled by, or is under common control with such party, or has the power to direct or cause the direction of the
</FONT></P>

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 <P STYLE="margin-top:0px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">
management and policies of a Party, whether through the ownership of voting securities, by contract or otherwise. Control will be presumed if one Party owns, either of record or beneficially,
more than 50% of the voting stock of any other Party, at the applicable time during the term of this Agreement. When used in this definition the word &#147;control&#148; is not intended to be a form of the defined term &#147;Controlled&#148;.
</FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>&#147;ARCA Field&#148;</B> means the field of pharmaceutical therapeutics, including any companion genetic diagnostic
which is indicated for use with a pharmaceutical therapeutic. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>&#147;Bankruptcy Event&#148;</B> means the occurrence of any
of the following: voluntary or involuntary proceedings by or against such Party are instituted in bankruptcy or under any insolvency law, or a receiver or custodian is appointed for such, or proceedings are instituted by or against such Party for
corporate reorganization or the dissolution of such Party, which proceedings, if involuntary, shall not have been dismissed within sixty (60)&nbsp;days after the date of filing, or such Party makes an assignment for the benefit of its creditors, or
substantially all of the assets of such Party are seized or attached and not released within sixty (60)&nbsp;days thereafter. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>&#147;Bucindolol&#148;</B> means the beta-adrenergic-receptor antagonist having the chemical formula bucindolol HCL
(oral)2-{2-hydroxy-3{{2-(3-indolyl)-1, 1-dimethylethyl}amino}propxy}-benzonit, and its racemates, isomers, prodrugs, active metabolites, analogs and any pharmaceutically acceptable salt or complex thereof. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%;padding-bottom:0px; "><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>&#147;CareLink&#148;</B> or the &#147;<B>CareLink System</B>&#148; means Medtronic&#146;s proprietary remote
monitoring service that provides secure access to data from patients who have certain Medtronic cardiac medical device implants, including Reveal, that is currently marketed by Medtronic under the CareLink<FONT
STYLE="font-family:Times New Roman" SIZE="1"><SUP STYLE="vertical-align:baseline; position:relative; bottom:.8ex">&reg;</SUP></FONT> trademark. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>&#147;CareLink Data&#148;</B> means data received by CareLink from the Medtronic Devices implanted in the patients in GENETIC-AF who are enrolled in CareLink, including information measuring AF Burden,
for the applicable Data Collection Period. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>&#147;Change of Control&#148;</B> means an event as a result of which the
holders of the outstanding voting securities of a Party or the Persons with the power to direct or cause the direction of the management and policies of a Party as of the Effective Date of this Agreement cease to own a majority of the outstanding
voting securities of such Party or the power to direct or cause the direction of the management and policies of such Party. When used in this definition the word &#147;control&#148; is not intended to be a form of the defined term
&#147;Controlled&#148;. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>&#147;Controlled&#148;</B> means the legal authority or right of a Party hereto to grant a license
or sublicense of intellectual property rights to another Party hereto, or to otherwise disclose proprietary or trade secret information to such other Party, without breaching the terms of any agreement with a Third Party, infringing upon the
intellectual property rights of a Third Party, or misappropriating the proprietary or trade secret information of a Third Party. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>&#147;CRMA Services&#148;</B> means the collection and analysis by Medtronic pursuant to Sections 5.1-5.3 of this Agreement of cardiac rhythm data collected from patients while they are enrolled in the
Phase 2B or Phase 3 portion of the GENETIC-AF trial through the use of Medtronic Devices implanted by physicians. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>&#147;Data Collection Period&#148;</B> means the period during which the Protocol requires the CRMA Services to collect data for the
patients. </FONT></P>
 <p STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">Clinical Trial
Collaboration Agreement&#151;Confidential&#151;Page 2 </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">[ * ] = Certain confidential information contained in this document, marked by
brackets, is filed with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. </FONT></P>


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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>&#147;De-identify&#148;</B> and &#147;<B>De-identification</B>&#148; mean removal of
information that identifies individuals in a manner that conforms with the standard in Section&nbsp;164.514 (a)&nbsp;of the HIPAA Privacy Rule. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>&#147;Drug Product&#148;</B> means any pharmaceutical preparation in finished dosage form containing Bucindolol for administration to human patients. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>&#147;Drug Product Application&#148;</B> means the application needed to obtain Drug Product Approval in any particular country or
jurisdiction in the world, such as an NDA. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>&#147;Drug Product Approval&#148;</B> means the regulatory approval of the Drug
Product by a regulatory authority in any country , such as the approval by the FDA of a NDA for the Drug Product. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>&#147;FDA&#148; </B>means the United States Food and Drug Administration or any successor agency thereto. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>&#147;GENETIC-AF&#148;</B> means the Phase 3 clinical trial described in Section&nbsp;2.1. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>&#147;Governmental Authority&#148;</B> means any applicable federal, state, local or other governmental body with jurisdiction over
the applicable subject matter. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>&#147;HIPAA&#148;</B> means the Health Insurance Portability and Accountability Act of
1996, Public Law 104-191 and the regulations promulgated thereunder. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>&#147;ICD&#148; </B>means implantable cardioverter
defibrillator. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>&#147;Know-How&#148;</B> means all proprietary material and information including data, clinical data,
technical information, know-how, experience, inventions, discoveries, trade secrets, compositions of matter and methods, process, techniques, products, materials and compositions. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>&#147;Medtronic Device&#148;</B> means a Reveal or a Medtronic CRT or ICD with atrial leads. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>&#147;Medtronic Field&#148;</B> means the field relating to electrical monitoring and implanted medical devices for humans and
animals. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>&#147;NDA&#148;</B> means a New Drug Application for marketing approval of the Drug Product, filed with the FDA.
</FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>&#147;Party&#148;</B> means ARCA or Medtronic, and &#147;<B>Parties</B>&#148; means ARCA and Medtronic. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>&#147;Patents&#148;</B> means all existing patents and patent applications and all patent applications hereafter filed, including any
continuation, continuation-in-part, division, provisional or any substitute applications, any patent issued with respect to any such patent applications, any reissue, reexamination, renewal or extension (including any supplementary protection
certificate) of any such patent, and any confirmation patent or registration patent or patent of addition based on any such patent, and all foreign counterparts of any of the foregoing. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>&#147;Person&#148;</B> means any individual, corporation, partnership, association, joint-stock company, trust, unincorporated
organization or government or political subdivision thereof. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>&#147;Phase 2B Study&#148;</B> means the initial Phase 2
portion of the GENETIC-AF trial. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>&#147;Phase 3 Portion&#148; </B>means the continuation of the GENETIC-AF trial beyond 200
patients enrolled, up to approximately 620 patients enrolled. </FONT></P>
 <p STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">Clinical Trial
Collaboration Agreement&#151;Confidential&#151;Page 3 </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">[ * ] = Certain confidential information contained in this document, marked by
brackets, is filed with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. </FONT></P>


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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>&#147;Primary Publication&#148;</B> means publication of trial results for the first
time, in contrast to review articles. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>&#147;Protocol&#148;</B> means the protocol for the Phase 2B Study a summary of
which is attached hereto as Appendix A, as amended from time to time in the manner provided for in this Agreement. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>&#147;Regulatory Approval&#148;</B> means any and all approvals, clearances or other authorizations of the FDA necessary for the
commercial sale of Drug Product for human use in the United States. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>&#147;Regulatory Authority&#148;</B> means any
Governmental Authority with jurisdiction over drug products or medical devices intended for human use in the United States, including in the United States, the FDA. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%;padding-bottom:0px; "><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>&#147;Reveal&#148;</B> means Medtronic&#146;s REVEAL<FONT STYLE="font-family:Times New Roman" SIZE="1"><SUP
STYLE="vertical-align:baseline; position:relative; bottom:.8ex">&reg;</SUP></FONT>XT implantable cardiac monitor, and next generation equivalent product. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>&#147;Steering Committee&#148;</B> means the steering committee established pursuant to section 5.6. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>&#147;Territory&#148;</B> means world-wide. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>&#147;Third Party&#148;</B>
means any person or entity that is not a Party or an Affiliate of any Party to this Agreement. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>&#147;Trial
Sponsors&#148;</B> means Third Parties that may provide financing for the GENETIC-AF trial, including the United States Department of Veterans Affairs, the National Institutes of Health, or commercial pharmaceutical companies. </FONT></P>
<P STYLE="margin-top:24px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>ARTICLE II </B></FONT></P>
<P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>CONDUCT OF STUDY </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>2.1 GENETIC-AF Clinical Trial Background. </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">ARCA intends to conduct one or
more clinical trials of the Drug Product. <B>GENETIC-AF</B> is the first clinical trial, which is anticipated to be a 620-patient, Phase 3 study comparing the Drug Product to metoprolol CR/XL for prevention of atrial fibrillation,
post-cardioversion, in patients with heart failure and reduced left ventricular ejection fraction (<B>&#147;HFREF</B>&#148;), the protocol summary for which is attached hereto as Appendix A. GENETIC-AF is planned as an adaptive design, according to
which it will be initiated as a Phase 2b study in approximately 200 HFREF patients and will measure AF Burden as a clinical endpoint in all of those patients, through the use of implanted insertable cardiac monitors, ICD&#146;s or cardiac
resynchronization therapy devices (the &#147;<B>Phase 2B Study</B>&#148;). GENETIC-AF may be expanded to a Phase 3 study in a total of approximately 620 patients depending on the outcome of the initial Phase 2B Study, as more specifically described
in Section&nbsp;5.4 hereof. Although it is anticipated that GENETIC-AF may have one or more Trial Sponsors in addition to ARCA, [ * ] when permitted under Section&nbsp;5.1(a) hereof. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>2.2 Conduct of GENETIC-AF. </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>ARCA shall conduct GENETIC-AF at no cost to Medtronic, other than the costs incurred by Medtronic to perform the obligations it assumes in this Agreement. GENETIC-AF shall be conducted in
accordance with the requisite approvals of the FDA, and according to the Protocol, provided, that the Protocol may be revised based on the determination of the Steering Committee as a result of FDA guidance or other factors. </FONT></P>
 <p STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">Clinical Trial
Collaboration Agreement&#151;Confidential&#151;Page 4 </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">[ * ] = Certain confidential information contained in this document, marked by
brackets, is filed with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. </FONT></P>


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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>The sponsors of GENETIC-AF shall comply with all applicable laws and regulations
governing sponsors of clinical trials and shall be responsible for complying with agreements with the institutions representing the investigative sites, and providing appropriate information to and monitoring of the investigators so that GENETIC-AF
is performed by those investigators in conformance with generally accepted standards of good clinical practice, with the Protocol and with all applicable local, state and federal laws and regulations governing the performance of clinical
investigations including, but not limited to, the United States Food, Drug and Cosmetic Act and the regulations of the FDA. ARCA shall be responsible for and have the sole authority to conduct all regulatory activities required to secure FDA
approval of GENETIC-AF </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c) </B>The sponsors of GENETIC-AF shall be responsible, subject to the responsibilities of the
investigators selected and the institutions, and contract research organizations engaged by ARCA, for the conduct of all aspects of GENETIC-AF, including protocol design study management, and data analysis (except for the data analysis Medtronic
conducts as part of the CRMA Services. Medtronic, through its participation in the CRMA Committee and the Steering Committee, will provide review of any investigators and institutions involved in the Phase 2B Study and provide site recommendations
to ARCA. Additional site support from Medtronic requires prior mutual agreement by ARCA and Medtronic. All compensation of such investigators and institutions shall be the responsibility of ARCA. Except as otherwise set forth in this Agreement
relating to Medtronic&#146;s obligations, ARCA shall be responsible for the payment of all costs relating to GENETIC-AF, whether direct or indirect. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(d) </B>ARCA shall include in the informed consents and research authorizations required to be signed by GENETIC-AF participants the appropriate language to permit the Parties to have access to and
utilize the data as provided in this Agreement and in compliance with state and federal laws, including HIPAA. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(e)
</B>ARCA shall enroll the first patient in the Phase 2B Study no later than December&nbsp;1, 2014. </FONT></P> <P STYLE="margin-top:24px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>ARTICLE III
</B></FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>LICENSE GRANTS </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>3.1 License in the Medtronic Field.</B> Subject to and in accordance with the other provisions of this Agreement, ARCA hereby grants to Medtronic (and its Affiliates) an exclusive perpetual, worldwide,
non-royalty-bearing, and fully paid-up license to use the De-identified Study Data for research and commercial purposes (including, but not limited to regulatory, IP filings, and marketing claims support) in the Medtronic Field. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>3.2 License in the ARCA Field.</B> Subject to and in accordance with the other provisions of this Agreement, Medtronic hereby grants
to ARCA and its Affiliates an exclusive perpetual, worldwide, non-royalty-bearing, and fully paid-up license to use the CareLink Data for research and commercial purposes (including, but not limited to regulatory, IP filings, and marketing claims
support) in the ARCA Field. </FONT></P>
 <p STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">Clinical Trial
Collaboration Agreement&#151;Confidential&#151;Page 5 </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">[ * ] = Certain confidential information contained in this document, marked by
brackets, is filed with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. </FONT></P>


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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>3.3 No Implied Licenses.</B> Except as specifically set forth in this Agreement, neither
Party shall acquire any license or other intellectual property interest, by implication or otherwise, to any information disclosed to it under this Agreement or under any Patents or Know-How Controlled by the other Party or its Affiliates. The
rights granted to Medtronic in this Agreement convey no rights to the development, manufacture, use, sell, offer for sale, importation or any other rights to the Drug Product, which rights are expressly reserved exclusively to ARCA, and shall not
interfere with or restrict, in any way, ARCA&#146;s rights, or those of its licensees, to develop, make, have made, perform, use, sell, offer for sale, import or otherwise commercialize the Drug Product. The rights granted to ARCA in this Agreement
convey no rights to the development, manufacture, use, sell, offer for sale, importation or any other rights to Reveal, which rights are expressly reserved exclusively to Medtronic, and shall not interfere with or restrict, in any way,
Medtronic&#146;s rights, or those of its licensees, to develop, make, have made, perform, use, sell, offer for sale, import or otherwise commercialize Reveal. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>3.4 Right of First Refusal.</B> ARCA shall not use the Combined Study Data outside the ARCA Field unless Medtronic first declines to participate with ARCA in the proposed joint activity. ARCA shall
give Medtronic written notice of its interest in using the Combined Study Data outside the ARCA Field, which notice shall contain a summary of ARCA&#146;s proposed activity. Medtronic shall promptly respond in writing. Medtronic shall be deemed to
have declined to participate if it fails to give ARCA written notice of its interest (&#147;<B>Interest Notice</B>&#148;) no more than 30 days (or such longer period that ARCA may agree to in writing) after ARCA&#146;s notice. In the event that
Medtronic provides the Interest Notice, both Parties shall negotiate the terms of a definitive agreement concerning the proposed joint activity in good faith. If the Parties are unable to enter into a definitive agreement for the proposed activity
within 60 days after the Interest Notice (or such longer period after the Interest Notice that the parties may agree to in writing), either Party may give written notice terminating the discussions and ARCA shall be free to use the Combined Study
Data outside the ARCA Field (but not in the Medtronic Field) for the activity proposed by ARCA. </FONT></P> <P STYLE="margin-top:24px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>ARTICLE IV </B></FONT></P>
<P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>GENERAL; CRMA COMMITTEE </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>4.1 CRMA Committee.</B> In accordance with the terms and conditions of this Agreement, the Parties shall consult with a committee (the &#147;<B>CRMA Committee</B>&#148;) which shall be comprised of an
equal number of representatives from each of ARCA and Medtronic and which shall oversee the Medtronic-ARCA collaboration and all other activities provided for under this Agreement. The CRMA Committee may have up to eight members and may add, as
appropriate, representatives of any Third Party vendor (if any) retained by Medtronic to assist in the CRMA Services under this Agreement. Each of ARCA and Medtronic shall, as soon as practical, notify the other Party in writing of the names of its
representative members to the CRMA Committee. The CRMA Committee will be co-chaired by one co-chairperson designated by ARCA and one co-chairperson designated by Medtronic. Members of the CRMA Committee shall serve in such capacities, on such terms
and conditions, and for such duration as shall be determined by the Party appointing same. Each Party may designate an alternate member or co-chairperson to serve temporarily in the absence of a permanent member or co-chairperson designated by such
Party. Each Party may from time to time change its co-chairperson or its representative members on the CRMA Committee by notifying the other party in writing. </FONT></P>
 <p STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">Clinical Trial
Collaboration Agreement&#151;Confidential&#151;Page 6 </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">[ * ] = Certain confidential information contained in this document, marked by
brackets, is filed with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. </FONT></P>


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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>4.2 Meetings of the CRMA Committee.</B> Unless otherwise agreed by the Parties from time
to time, the CRMA Committee will meet at such times and places and with such frequency as determined by the Parties, but no less frequently than annually. The CRMA Committee may conduct meetings in person or by conference telephone or video
conference, and may also act without a meeting if approved by each co-chair (or his/her designee). The co-chairs will keep minutes reflecting actions taken at meetings, which the Parties will use their reasonable efforts to cause to be circulated
and signed by each co-chair following each meeting. The CRMA Committee may amend or expand upon the foregoing procedures for its internal operation at a meeting of the CRMA Committee or by written agreement of the Committee co-chairs. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>4.3 Functions and Powers of the CRMA Committee.</B> The CRMA Committee shall oversee the Medtronic-ARCA collaboration and all other
activities provided for under this Agreement, including the following functions: </FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>Coordinate the provision of the
CRMA Services by Medtronic for the Phase 2B Study, and the preparation of the Combined Study Data and the provision of the De-identified Study Data; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>consult with both Parties on the analysis Medtronic performs on the CareLink Data; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(c) </B>in connection with any regulatory submissions regarding the Drug Product and that 1) involve the CRMA Services, and 2) relate to the Phase 2B Study, the GENETIC-AF Trial, or any submission
relating to Regulatory Approval of the Drug Product based on the GENETIC-AF Trial, consult with both Parties concerning the filing and coordinate any input from Medtronic in the filings as necessary or advisable; </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(d) </B>coordinate the provision of the CRMA Services for the Phase 3 Portion of GENETIC-AF, if it is conducted. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(e) </B>perform such other functions as appropriate to further the purposes of this Agreement as determined by the Parties.
</FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>4.4 CRMA Committee Actions or Decisions.</B> Actions or decisions by the CRMA Committee pursuant to the terms of this
Agreement shall be taken or made by the unanimous vote of the co-chairpersons of the CRMA Committee. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>4.5 Limits of Powers
of the CRMA Committee.</B> The CRMA Committee shall only have such powers as are specifically delegated to it hereunder or as the Parties may otherwise agree in writing from time to time. The CRMA Committee is not empowered to take actions that
violate this Agreement. For the avoidance of doubt, the CRMA Committee shall not have the authority to modify the Protocol or any of the other powers delegated to the Steering Committee. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>4.6 Disputes.</B> If the CRMA Committee fails to reach agreement on a matter before it for consideration, then either Party may by
written notice to the other Party invoke the dispute resolution procedure set forth in <B>Article X</B>, unless otherwise indicated in this Agreement. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>4.7 Agendas.</B> Each Party will notify the other a reasonable period prior to the date of a meeting of the CRMA Committee, proposing the agenda items it wishes to discuss at such meeting.
</FONT></P>
 <p STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">Clinical Trial
Collaboration Agreement&#151;Confidential&#151;Page 7 </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">[ * ] = Certain confidential information contained in this document, marked by
brackets, is filed with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. </FONT></P>


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 <P STYLE="margin-top:0px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">
Notwithstanding the foregoing, the CRMA Committee shall be free to consider any matter related to this Agreement which is within the scope of its responsibilities and is brought to its attention
by any Party at any meeting. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>4.8 Publications.</B> ARCA may publish GENETIC-AF Trial findings. For Primary Publications
the design and content will be determined in consultation with the Steering Committee. ARCA will consult with Medtronic regarding publications if CareLink Data is included as part of publication and coordinate timing to permit Medtronic to file
applications for appropriate patents if applicable. Such consultation and review period shall not be longer than 45 days. Medtronic may publish findings specific to the Medtronic Field of Use, in consultation with the Steering Committee for Primary
Publications. Medtronic will consult with ARCA regarding publications and coordinate timing to permit ARCA to file applications for appropriate patents if applicable. Such consultation and review period shall not be longer than 45 days. </FONT></P>
<P STYLE="margin-top:24px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>ARTICLE V </B></FONT></P>
<P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>PHASE 2B STUDY; CRMA SERVICES </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>5.1 Phase 2B Study Design; CRMA Services.</B> The Parties shall meet as soon as reasonably practical, but no less than 120 days prior to enrollment of the first patient in the GENETIC-AF trial to
discuss the GENETIC-AF trial Protocol and the design of the Phase 2B Study, including a substudy to monitor and analyze AF Burden (the &#147;<B>AF Burden Substudy</B>&#148;). The Parties shall negotiate in good faith to agree on the specific
elements of the AF Burden Substudy and the CRMA Services for the AF Burden Substudy to be provided by Medtronic (&#147;<B>AF Burden Substudy Protocol</B>&#148;), which shall be signed by the parties and appended to this Agreement as Appendix B by
August&nbsp;15, 2013. It is not bad faith for Medtronic to refuse to agree to undertake obligations in the AF Burden Substudy Protocol that materially exceed the obligations it agrees to undertake in this Agreement. Unless otherwise agreed- to by
the Parties, the Protocol, the AF Burden Substudy Protocol, and the CRMA Services shall contain the relevant elements set forth in this Article V. Once agreed upon by the Parties, the AF Burden Substudy Protocol, and the applicable elements of the
GENETIC-AF trial Protocol shall not be varied without the agreement of Medtronic; provided, that the Steering Committee at all times retains discretion over the conduct of GENETIC-AF, including the discretion to make changes to the Protocol, the AF
Burden Substudy Protocol, or the conduct of GENETIC-AF whenever it deems such changes advisable for any reason. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a)</B>
Medtronic will use its CareLink System and the Medtronic Devices implanted in patients in the Phase 2B Study to support the collection and analysis of AF burden data from up to 200 patients enrolled in the Phase 2B Study. [ * ] The AF Burden
Substudy Protocol will require that the patients in the Phase 2B Study will either have an existing implanted Medtronic Device, or will have a Reveal inserted as part of enrollment in the Phase 2B Study. The AF Burden Substudy Protocol will also
require that all patients be enrolled in CareLink. Notwithstanding the foregoing, the AF Burden Substudy Protocol may permit trial participants to have monitoring devices other than the Medtronic Devices (&#147;<B>Competitive Device</B>&#148;)
implanted or inserted, if the Medtronic Devices or the CareLink System are not available to patients in the GENETIC-AF Trial without unreasonable delay, due to voluntary or involuntary product recalls,. Medtronic has no obligation to provide CRMA
Services in connection with Competitive Devices. </FONT></P>
 <p STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">Clinical Trial
Collaboration Agreement&#151;Confidential&#151;Page 8 </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">[ * ] = Certain confidential information contained in this document, marked by
brackets, is filed with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. </FONT></P>


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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b)</B> The investigator nomination criteria will either require that all candidates are
CareLink users or attempt to determine which investigators are not CareLink users. If physicians who are not CareLink users are selected to participate in the Phase 2B Study, ARCA shall supply Medtronic with the names of such physicians and the
business entity with which they are affiliated as soon as practical. Medtronic shall thereafter offer such investigators who are not current CareLink users Medtronic&#146;s standard CareLink Agreement and Business Associate Agreement, and shall
negotiate in good faith to execute such agreements with the investigators. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>5.2</B> The Parties shall agree on an
enrollment plan for the Phase 2B Study to ensure that all patients eligible for the study are actively enrolled, including those with existing Medtronic Devices and those willing to have a Reveal device implanted. ARCA, through the Steering
Committee, will exercise its best efforts to ensure that enrollment is at a rate likely to result in at least [ * ] of the patients enrolled in the Phase 2B Study having a Reveal device as a means of continuous monitoring (as opposed to another type
of Medtronic Device). Eligible patients without a Medtronic Device will be implanted with a Reveal without unreasonable delay, which may result in substantially more than [ * ] of the Phase 2B Study participants receiving a Reveal device. If, in the
course of the Phase 2B Study, the Steering Committee concludes for any reason that the [ * ] Reveal device criterion is unable or impractical to be met, the CRMA Committee will determine if it is appropriate to continue the trial at a lower Reveal
proportion of the total number of monitoring devices. Medtronic shall ensure that sufficient Reveal devices and patient monitors are reasonably available to all Phase 2B Study sites, in order to meet the [ * ] threshold and avoid unreasonable delay
in the enrollment process. In addition, Medtronic shall provide training and technical support for Medtronic Devices, including training relating to insertion and use of Reveals, to the investigators. Medtronic will support the reimbursement process
for Reveal and the patient monitors, including insertion, by providing information about reimbursement opportunities to investigators. If reimbursement for the Reveal device and patient monitor is denied for a patient who receives one during
enrollment in the Phase 2B Study after the implanting physician has made reasonable efforts and cooperated with Medtronic in pursuit of reimbursement, [ * ], taken in the order of reimbursement denial, by [ * ].&nbsp;The Parties agree that the
payments made by Medtronic hereunder: (a)&nbsp;are consistent with the fair market value of the applicable services and are inclusive of any and all applicable fees, personnel costs, overhead and the like; and (b)&nbsp;have not been determined in a
manner that takes into account the volume or value of any referrals or business otherwise generated between the Parties and any third party.&nbsp;The Parties also agree that the payments made by Medtronic described in this Section&nbsp;5.2
constitute the complete and full compensation owed by Medtronic to ARCA for the work performed under this Agreement and Medtronic shall not be liable to ARCA or to any third party for any other payments which may be associated with this Agreement or
with any of the services provided hereunder. ARCA shall provide Medtronic with an invoice along with accompanying documentation, in a form satisfactory to Medtronic, of the contracted implant&nbsp;&amp; physician fees for which payment is sought
under this Section&nbsp;5.2.&nbsp;All fees sought for a given patient shall be included on a single invoice.&nbsp;Medtronic is not required to make any payment to ARCA for any invoice submitted hereunder until it has had the required documentation
for at least 30 days, and ARCA shall not submit invoices to Medtronic more often than once every three months. </FONT></P>
 <p STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">Clinical Trial
Collaboration Agreement&#151;Confidential&#151;Page 9 </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">[ * ] = Certain confidential information contained in this document, marked by
brackets, is filed with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. </FONT></P>


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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>5.3 Data and Analysis. </B></FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>Subject to the CareLink and device settings configured by the physician, Medtronic shall collect and maintain in CareLink all
of the CareLink Data for the patients in the Phase 2B Study for the Phase 2B Study Data Collection Period. CareLink does not collect information from devices that are interrogated by a programmer. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>The CareLink Data will be retained by CareLink pursuant to Medtronic&#146;s standard CareLink operating procedures and its
agreements with the patients&#146; physicians. Medtronic shall provide ARCA with a copy of the CareLink Data in the standard CareLink format or such other mutually agreed format at the end of the Data Collection Period and other mutually agreed
times. Unless Medtronic determines to its satisfaction that it is not needed under applicable law, ARCA and Medtronic shall enter into a mutually agreed Sub Business Associate Agreement (as defined in HIPAA regulations) prior to the transfer to ARCA
of CareLink Data that is not De-identified. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c) </B>Within 60 days after receipt of the CareLink Data from Medtronic, ARCA
shall [ * ] merge the CareLink Data with all other hard locked and clean patient-level data that stems from GENETIC-AF (&#147;<B>Combined Study Data</B>&#148;), De-identify a copy of the Combined Study Data (&#147;<B>De-identified Study
Data</B>&#148;) and provide a copy of the De-identified Study Data to Medtronic. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(d) </B>As between the Parties, Medtronic
owns the CareLink Data, and ARCA owns the Combined Study Data and the De-identified Study Data. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(e) </B>Data will be
provided in a mutually agreed format. Medtronic will provide mutually agreed analysis assistance on the CareLink Data. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>5.4
GENETIC-AF Phase 3 Portion. </B>If ARCA conducts the Phase 3 Portion of GENETIC-AF, Medtronic shall provide the CRMA Services for the Phase 3 Portion, subject to all the applicable terms and conditions of this Agreement, with the following
modifications. ARCA shall seek to enroll at least 100 patients in the Phase 3 Portion who have either existing Medtronic Devices, or are implanted with a Reveal device as part of the enrollment process, but this shall not be a requirement. Medtronic
shall ensure that sufficient Reveal devices and patient monitors are reasonably available to all Phase 3 Study sites in order to meet the 100 patient goal and avoid unreasonable delay in the enrollment process. Medtronic will support the
reimbursement process for Reveal and the patient monitors, including insertion, in the Phase 3 Portion by providing information about reimbursement opportunities to investigators, [ * ]. Medtronic shall collect and maintain CareLink Data for the
Data Collection Period of the Phase 3 Portion, and shall provide a copy of this CareLink Data to ARCA at the end of the Data Collection Period for the Phase 3 Portion. Within 60 days after receipt of the CareLink Data from Medtronic, ARCA shall
create Combined Study Data for the Phase 3 Portion and provide a copy of De-identified Study Data for the Phase 3 Portion to Medtronic. At the same time, ARCA shall also provide Medtronic with a copy of De-identified Study Data containing the data
from both Phase 2B Study and the Phase 3 Portion unless the De-identified Study Data provided for the Phase 2B Study and Phase 3 Portions are in a format that allows Medtronic to easily and accurately merge the two data sets. </FONT></P>
 <p STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">Clinical Trial
Collaboration Agreement&#151;Confidential&#151;Page 10 </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">[ * ] = Certain confidential information contained in this document, marked by
brackets, is filed with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. </FONT></P>


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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>5.5 Regulatory Process&nbsp;&amp; Approval. </B></FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>ARCA will, through the CRMA Committee, involve Medtronic in all regulatory communications and actions that implicate
Medtronic&#146;s rights and duties under this Agreement, or that implicate the use of Medtronic Devices. Medtronic will consult on the regulatory process related to conducting GENETIC-AF and to a subsequent NDA filed with the FDA for Regulatory
Approval of Gencaro based on GENETIC-AF, as reasonably requested by ARCA. The Parties do not believe that an Investigational Device Exemption (&#147;IDE&#148;) will be necessary in order to use Reveal in the Phase 2B Study, and the Protocol shall
not be amended in a way that will require use of Reveal in a manner inconsistent with FDA approval of Reveal. Medtronic, however, agrees to file and prosecute any regulatory application or submission that in Medtronic&#146;s sole judgment is
required by any Regulatory Authority in order for Medtronic to perform the CRMA Services required by this Agreement. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b)
</B>ARCA will consult with, and allow participation by Medtronic on a reasonable basis regarding the content of any submissions to Regulatory Authorities related to the GENETIC-AF trial or any Drug Product Application to the extent it involves the
CRMA Services, Medtronic Devices, or the Medtronic Field of Use, and will provide Medtronic with the opportunity to attend or participate in all substantial contacts, including meetings and conference calls, between ARCA and the FDA and any other
Regulatory Authority relating to the CRMA Services Medtronic Devices, or the Medtronic Field of Use. Medtronic will consult with, and allow participation by ARCA on a reasonable basis regarding the content of any submissions to the FDA related to
the CRMA Services, and will provide ARCA with the opportunity to attend or participate in all substantial contacts, including meetings and conference calls, between Medtronic and the FDA related to the CRMA Services. Medtronic is responsible for
submitting reportable events relating to Medtronic Devices. Notwithstanding the foregoing, each Party shall notify the other Party of any oral or written communications to or from the FDA on matters relating to the CRMA Services, and shall provide
the other Party with copies of any such communications reasonably promptly and give the other Party the right to review and participate in any response to any such communications. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>5.6 GENETIC-AF Steering Committee.</B> ARCA will create a steering committee to oversee the conduct of GENETIC-AF. The Steering
Committee shall approve the GENETIC-AF Protocol, prior to inception of the GENETIC-AF trial, and shall monitor and supervise the progress of GENETIC-AF and ensure that it is conducted in accordance with the principles of good clinical practice and
applicable law and regulations. The Steering Committee has discretion over any amendments to the Protocol and over decisions relating to the continuation or termination of GENETIC-AF. Medtronic is entitled to have one representative serve as a
non-voting member of the Steering Committee. As a member of the Steering Committee, Medtronic is entitled to consult on and deliberate any proposed changes to the design of GENETIC-AF, and in any other issues which may have an effect on the
study&#146;s conduct, outcome, or publication. </FONT></P>
 <p STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">Clinical Trial
Collaboration Agreement&#151;Confidential&#151;Page 11 </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">[ * ] = Certain confidential information contained in this document, marked by
brackets, is filed with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. </FONT></P>


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 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>ARTICLE VI </B></FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>INVENTIONS; CONFIDENTIALITY; PUBLICITY </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>6.1 Inventions.</B> All
information, discoveries, knowledge, experience, processes, procedures, inventions, devices, skills, Know-How, samples, trade secrets, clinical data, designs, formulations, specifications, methods, techniques, technical information, compilations,
concepts, developments, inventions and improvements, whether patentable or not, and any associated patent, copyright, trade secret, or other intellectual property rights (&#147;<B>New Inventions</B>&#148;) in the ARCA Field of Use arising from the
performance of this Agreement, as well as New Inventions arising from ARCA&#146;s performance of this Agreement and that are made, conceived, developed, or reduced to practice solely by ARCA after complying with Section3.4 (Right of First Refusal),
other than New Inventions in the Medtronic Field of Use, shall be owned by ARCA (collectively, the &#147;<B>ARCA Inventions</B>&#148;). All New Inventions in the Medtronic Field of Use arising from the performance of this Agreement, as well as New
Inventions arising from Medtronic&#146;s performance of this Agreement and that are made, conceived, developed, or reduced to practice solely by Medtronic, other than New Inventions in the ARCA Field of Use, shall be owned by Medtronic
(collectively, the &#147;<B>Medtronic Inventions</B>&#148;). All New Inventions other than ARCA Inventions and Medtronic Inventions arising from the performance of this Agreement and that are made, conceived, developed, or reduced to practice
jointly by at least one employee or agent of ARCA and at least one employee or agent of Medtronic (collectively, &#147;<B>Joint Inventions</B>&#148;) shall be jointly owned by the Parties. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>6.2 Assignment; Licenses.</B> ARCA shall assign to Medtronic ARCA&#146;s rights to any and all New Inventions in the Medtronic Field
that arise out of this Agreement. Medtronic shall assign to ARCA Medtronic&#146;s rights to any and all New Inventions in the ARCA Field arising out of this Agreement. Each Party agrees that it will execute and deliver all assignments and other
documents as may be necessary or appropriate to assign its rights to any Joint Inventions to the other Party as contemplated by this Agreement. Subject to the terms and conditions of this Agreement (including the licenses granted hereunder),
Medtronic and ARCA shall each retain their respective unrestricted rights to make, have made, use, sell, have sold, and import, respectively, the Medtronic Inventions and the ARCA Inventions. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>6.3 Confidentiality; Exceptions.</B> Except to the extent expressly authorized by this Agreement or otherwise agreed in writing, the
Parties agree that, for the term of this Agreement and for ten years thereafter, the receiving Party shall keep confidential and shall not publish or otherwise disclose or use for any purpose other than as provided for in this Agreement any
information, data and materials, including scientific, pre-clinical, clinical, regulatory, manufacturing, marketing, financial, and commercial information furnished to it by the other Party pursuant to this Agreement that is designated Confidential
in writing by the disclosing Party (collectively, &#147;<B>Confidential Information</B>&#148;). A Party that discloses information orally may designate it as Confidential Information by describing the orally disclosed information and designating it
Confidential in writing to the other Party within 10 days after the initial oral disclosure. The CareLink Data is the Confidential Information of Medtronic and the Combined Study Data and De-identified Study Data are the Confidential Information of
ARCA, regardless of any failure to hereafter so designate the information as Confidential. Designated information, data and materials are not Confidential Information to the extent that it can be established by the receiving Party that such
Confidential Information: </FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a)</B> was already known to the receiving Party, other than under an obligation of
confidentiality, at the time of disclosure by the other Party and such receiving Party has documentary evidence to that effect; </FONT></P>
 <p STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">Clinical Trial
Collaboration Agreement&#151;Confidential&#151;Page 12 </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">[ * ] = Certain confidential information contained in this document, marked by
brackets, is filed with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. </FONT></P>


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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>was generally available to the public or otherwise part of the public domain at
the time of its disclosure to the receiving Party; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c) </B>became generally available to the public or otherwise part of
the public domain after its disclosure and other than through any act or omission of the receiving Party in breach of this Agreement; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(d) </B>was disclosed to the receiving Party, other than under an obligation of confidentiality, by a Third Party who had no obligation to the disclosing Party not to disclose such information to
others; or </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(e) </B>was independently developed by the receiving Party without use of the Confidential Information of the
disclosing Party. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>6.4 Authorized Disclosure and Use.</B> Each Party may disclose the other Party&#146;s Confidential
Information hereunder to the extent such disclosure is reasonably necessary to exercise its rights and perform its duties under this agreement, and to the extent such disclosure is reasonably necessary in filing or prosecuting Patent applications,
prosecuting or defending litigation, or complying with applicable governmental regulations, provided that if a Party is required by law or regulation to make any such disclosure of the other Party&#146;s Confidential Information, it will, except
where impracticable for necessary disclosures, give reasonable advance notice to the other Party of such disclosure requirement and will where applicable use its reasonable efforts to seek confidential treatment of such Confidential Information
required to be disclosed. If disclosure is reasonably necessary to exercise a Party&#146;s rights or perform its duties under this agreement, the disclosing Party shall disclose the minimum necessary information and shall first obtain a
confidentiality agreement that protects the information from disclosure and use in a manner inconsistent with this Agreement. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>6.5 Survival.</B> This <B>Article VI</B> shall survive the termination or expiration of this Agreement for a period of ten years.
</FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>6.6 Publicity.</B> The Parties shall consult and coordinate with each other respecting the text and timing of any
publicity, press, or news releases or other public announcements or disclosures prior to issuance thereof regarding the existence or terms of this Agreement and the transactions contemplated hereby; <U>provided</U>, <U>however</U>, that neither
Party shall issue any such press releases, announcements or disclosures without the other Party's prior written consent, which may not be unreasonably withheld. Neither Party shall use the name, trademarks, trade name or logo of the other for
marketing, advertising, or promotional claims without the prior written consent of the other Party. It is unreasonable to withhold consent to such press releases or public statements or disclosures (such as in annual reports to stockholders or
filings with the Securities and Exchange Commission) that are required to comply with applicable laws and regulations. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>6.7
Specific Performance.</B> Each Party acknowledges and agrees that disclosure or distribution of the Confidential Information or use of the Confidential Information of the other Party contrary to the terms of this Agreement may cause irreparable harm
to the disclosing Party for which damages at law may not provide an adequate remedy and agrees that the provisions of this Article may be specifically enforced and are in addition to any and all other remedies available at law or in equity.
</FONT></P>
 <p STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">Clinical Trial
Collaboration Agreement&#151;Confidential&#151;Page 13 </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">[ * ] = Certain confidential information contained in this document, marked by
brackets, is filed with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. </FONT></P>


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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>6.8 Prosecution of ARCA Inventions</B><B>.</B> ARCA shall retain sole responsibility and
discretion for prosecution, maintenance and enforcement of the ARCA Inventions and of Joint Inventions in the ARCA Field, including any Patents relating thereto. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>6.9 Prosecution of Medtronic Inventions</B><B>.</B> Medtronic shall retain sole responsibility and discretion for the prosecution of the Medtronic Inventions and of Joint Inventions in the Medtronic
Field, including any Patents relating thereto. </FONT></P> <P STYLE="margin-top:24px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>ARTICLE VII </B></FONT></P>
<P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>REPRESENTATIONS, WARRANTIES AND COVENANTS </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>7.1 Mutual Representations, Warranties and Covenants</B><B>.</B> Each Party hereby represents, warrants and covenants to the other Party as follows: </FONT></P>
<P STYLE="margin-top:6px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>Such Party: (i)&nbsp;is a corporation duly organized, validly existing and in good standing under the laws of the jurisdiction
in which it is incorporated or organized; (ii)&nbsp;has the corporate power and authority and the legal right to enter into this Agreement and to perform its obligations hereunder; and (iii)&nbsp;has taken all necessary corporate action on its part
to authorize the execution and delivery of this Agreement and the performance of its obligations hereunder. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>This
Agreement is a legal and valid obligation binding upon such Party and enforceable in accordance with its terms, and the execution, delivery and performance of this Agreement by such Party does not conflict with any material agreement, instrument or
understanding, oral or written, to which it is a party or by which it is bound, nor violate any law or regulation of any court, governmental body or administrative or other agency having jurisdiction over it. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c) </B>All material consents, approvals and authorizations of all governmental authorities and other persons required to be obtained
by such Party in connection with the execution and delivery and performance of this Agreement have been and shall be obtained. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(d) </B>It&#146;s obligations and responsibilities under this Agreement will be performed in a competent manner in conformance with
the standard of care usually and reasonably expected in the performance of such activities, and in compliance with applicable federal, state and local laws, rules and regulations, as interpreted and enforced by Regulatory Authorities.
Notwithstanding anything in this Agreement, it shall not have any obligation or responsibility to perform any activity that is contrary to applicable federal, state and local laws, rules and regulations, as interpreted and enforced by Regulatory
Authorities. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(e) </B>Neither it nor any of its employees or agents rendering services pursuant to this Agreement is under
investigation by any Regulatory Authority, including the FDA, for activities that could form the basis of a debarment action or is presently debarred pursuant to the Generic Drug Enforcement Act of 1992, 21 U.S.C. &#167;&nbsp;335a, or any other
similar law of any other regulatory authority in the Territory. A Party shall notify the other Party and the CRMA Committee promptly after learning of any inquiry concerning or the commencement of any such proceeding involving such Party or any
person or entity related to or involved in such Party&#146;s performance of its obligations under this Agreement. </FONT></P>
 <p STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">Clinical Trial
Collaboration Agreement&#151;Confidential&#151;Page 14 </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">[ * ] = Certain confidential information contained in this document, marked by
brackets, is filed with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. </FONT></P>


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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(f) </B>If any Regulatory Authority conducts or gives notice to a Party of its intent
with respect to any activities under this Agreement to conduct an inspection at any facility of the Party or take any other regulatory action related to any activities under this Agreement, or if the Party becomes aware of any such governmental
inspection or other regulatory activity, the Party shall promptly give the other Party and the CRMA Committee notice thereof, including all information pertaining to any such inspections or actions, unless and only to the extent restricted by the
governmental or Regulatory Authority or applicable law. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(g) </B>It&#146;s personnel and consultants have, and shall have,
all training, licenses, approvals, certifications, immunizations, equipment and information necessary for safely and properly performing its obligations under this Agreement, and it will ensure that all such training, licenses, approvals,
certifications, immunizations, equipment and information are properly maintained throughout the conduct of it&#146;s activities under this Agreement. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(h) </B>It is and will remain (and shall use reasonable efforts to ensure any Third Party retained by it as permitted by this Agreement is and will remain) in substantial compliance with regulatory and
legal requirements, as interpreted and enforced by Regulatory Authorities. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(i) </B>Neither it nor any of its personnel or
any Third Party engaged to perform any activities hereunder have been the subject of an investigation or in research that was terminated, as the term &#147;termination&#148; is used in 21 C.F.R. &#167; 812.3(8), or have been the subject of
investigation or have been disqualified under 21 C.F.R. &#167; 312.7, nor have they been subjected to any restrictions or sanctions related to allegations of research or professional misconduct. </FONT></P>
<P STYLE="margin-top:24px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>ARTICLE VIII </B></FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>TERM AND TERMINATION </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>8.1 Term.</B> This Agreement shall commence as of
the Effective Date and, unless sooner terminated as provided herein, shall continue in effect for five years. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>8.2
Termination by Medtronic.</B> This Agreement may be terminated by Medtronic in whole or in part as provided below: </FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a)
</B>At any time during the term of this Agreement if ARCA materially breaches this Agreement, which breach is not cured within sixty (60)&nbsp;days of written notice thereof from Medtronic. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>At any time during the term of this Agreement upon written notice if ARCA becomes subject to a Bankruptcy Event. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c) </B>Upon at least sixty (60)&nbsp;written notice given after the FDA advises either Party in writing, or issues any written
decision, pronouncement, or other communication, including but not limited to letters, emails, website information, final guidance documents, or final rulemaking, either to the Parties, to the public or to Third Parties, which provides a reasonable
basis for concluding that the FDA will not allow the GENETIC-AF Trial to enroll or proceed. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(d) </B>Upon written notice if
on or after December&nbsp;1, 2014 the Phase 2B Study has not enrolled its first patient. </FONT></P>
 <p STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">Clinical Trial
Collaboration Agreement&#151;Confidential&#151;Page 15 </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">[ * ] = Certain confidential information contained in this document, marked by
brackets, is filed with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. </FONT></P>


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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(e) </B>Upon at least 10 days written notice given within thirty days after an action,
authorized or unauthorized, is taken by the Steering Committee, (e.g. an amendment of the Protocol) or a regulatory body that materially expands Medtronic&#146;s obligations hereunder beyond those Medtronic voluntarily undertakes by entering into
this Agreement. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(f) </B>Upon at least thirty days written notice if the parties do not agree to the AF Burden Substudy
Protocol by August&nbsp;15, 2013. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>8.3 Termination by ARCA.</B> This Agreement may be terminated by ARCA in whole or in
part as provided below: </FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>At any time during the term of this Agreement if Medtronic materially breaches this
Agreement, which breach is not cured within sixty (60)&nbsp;days of written notice thereof from ARCA. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b)</B> At any time
during the term of this Agreement upon written notice if Medtronic becomes and remains subject to a Bankruptcy Event. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c)
</B>At any time during the term of this Agreement upon written notice given by ARCA at least ninety (90)&nbsp;days prior to the effective date of such termination in the event that a claim is made by a Third Party that the performance of the CRMA
Services by Medtronic infringes or otherwise violates such Third Party&#146;s intellectual property rights, unless the claim is withdrawn during such ninety (90)&nbsp;day period, or Medtronic agrees to indemnify ARCA for any liability arising from
such claim. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(d) </B>Upon sixty (60)&nbsp;days notice from ARCA if ARCA reasonably determines, based on clinical or
regulatory considerations, that it cannot enroll or continue the GENETIC-AF Phase 2B or Phase 3 Portion. If ARCA terminates because it determines that it cannot enroll or continue the Phase 3 Portion, ARCA&#146;s obligation to provide Medtronic with
the De-identified Study Data from the Phase 2B study will survive termination. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(e) </B>Upon at least thirty days written
notice if the parties do not agree to the AF Burden Substudy Protocol by August&nbsp;15, 2013. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>8.4 Effect of
Termination.</B> </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>Upon termination of this Agreement for any reason, each Party shall cooperate with the other
Party for an orderly wind-down of the services provided for hereunder. Any termination of this Agreement as provided herein shall not be an exclusive remedy but shall be in addition to any remedies whatsoever that may be available to the terminating
party. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>Upon any termination or expiration of this Agreement, each Party shall return to the other Party all
Information of the other Party in such Party&#146;s Control, except that one copy may be retained solely for archival purposes. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c) </B>Surviving Rights. Except as expressly modified herein, the obligations and rights of the Parties under <B>Articles I, III, VII
through IX, Section&nbsp;5.3(d), the first sentence of Section&nbsp;5.5 (a), and Section&nbsp;6.5</B> will survive termination or expiration of this Agreement. </FONT></P>
 <p STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">Clinical Trial
Collaboration Agreement&#151;Confidential&#151;Page 16 </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">[ * ] = Certain confidential information contained in this document, marked by
brackets, is filed with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. </FONT></P>


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 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>ARTICLE IX </B></FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>LIMITATION OF LIABILITY </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>9.1 Limitation of Liability.</B> In no event
will either party be liable to the other party for any indirect, special, incidental, consequential, or punitive damages arising out of or in connection with this Agreement. </FONT></P> <P STYLE="margin-top:24px;margin-bottom:0px" ALIGN="center"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>ARTICLE X </B></FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>DISPUTE RESOLUTION </B></FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>10.1 Disputes.</B> </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>The Parties recognize that disputes may arise from time to time respecting this Agreement and the rights and obligations of the Parties under this Agreement (&#147;Disputes&#148;), and desire
to establish the procedures in this Article to facilitate their resolution in an expedient and commercially reasonable manner by mutual cooperation and without resort to litigation. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>Except as otherwise provided in this Agreement or agreed by the Parties, Disputes will be resolved as recited in this Article.
If the CRMA Committee is still active, Disputes must first be submitted to the CRMA Committee. If the CRMA Committee is unable to resolve such a dispute within thirty (30)&nbsp;days, either Party, by written notice to the other, may have such
dispute referred to their respective executive officers designated below or their successors, for attempted resolution by good faith negotiations: </FONT></P> <P STYLE="font-size:12px;margin-top:0px;margin-bottom:0px">&nbsp;</P><DIV ALIGN="right">
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="96%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE">


<TR>
<TD WIDTH="12%"></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD WIDTH="86%"></TD></TR>


<TR>
<TD VALIGN="top"> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>For&nbsp;Medtronic:</B></FONT></P>
<P STYLE="margin-top:0px;margin-bottom:1px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>For ARCA:</B></FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="top"> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">General Manager, CRDM Diagnostics Division</FONT></P> <P STYLE="margin-top:0px;margin-bottom:1px"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B></B>Chief Executive Officer of ARCA</FONT></P></TD></TR>
</TABLE></DIV> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">In the event the designated executive officers are not able to resolve the Dispute within thirty
(30)&nbsp;days after written notice by either Party referring the matter to them as provided herein, either Party may by written notice to the other commence the Arbitration process set forth in <B>Section&nbsp;10.2</B> below. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>10.2 Arbitration by Expert Panel.</B> Except to the extent otherwise provided in this Agreement or by agreement of the Parties, any
Dispute that remains unresolved after going through the process set forth in <B>Section&nbsp;10.1</B> above shall be subject to the following alternative dispute resolution process (&#147;<B>Arbitration</B>&#148;): </FONT></P>
<P STYLE="margin-top:6px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>The Party invoking the Arbitration shall give written notice (&#147;<B>Arbitration Notice</B>&#148;) thereof to the other
Party, setting forth in reasonable detail the issues to be resolved. As soon as possible but in any event within fifteen (15)&nbsp;days after such notice is given, each Party will appoint one neutral expert to serve as an arbitrator, and these two
arbitrators will as soon as possible but in any event within ten (10)&nbsp;days following delivery of such notice appoint a third neutral expert to serve as the third arbitrator (such three arbitrators, the &#147;<B>Panel</B>&#148;). </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>The members of the Panel shall be &#147;neutral&#148; in that they are not nor have they been within the previous five years
employees or paid consultants of either Party, nor have any other extended familial, close social or other material relation to either Party. </FONT></P>
 <p STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">Clinical Trial
Collaboration Agreement&#151;Confidential&#151;Page 17 </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">[ * ] = Certain confidential information contained in this document, marked by
brackets, is filed with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. </FONT></P>


<p Style='page-break-before:always'>
<HR  SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c) </B>The Panel shall hold a hearing (the &#147;<B>Hearing</B>&#148;) on the merits of
the dispute as soon as possible but in no event more than sixty (60)&nbsp;days following delivery of the Arbitration Notice. The Hearing shall be at a location and time mutually acceptable to the Parties. Each Party may submit one written brief,
along with reasonable supporting materials, setting forth the issues of the dispute and a specific suggested resolution requested by such Party, which will be submitted simultaneously to the Panel and the other Party. The Hearing shall take place
over a period of no more than two full consecutive business days (or if agreeable to the Panel and the Parties, calendar days) and will follow a reasonable and equitable procedure adopted by the Panel for presentations, questions and answers, and
discussions, provided however hearing time shall be allocated equally between the Parties. Within ten (10)&nbsp;days following the Hearing, the Panel will present its decision (&#147;<B>Decision</B>&#148;) in writing, acting with the concurrence of
at least two Arbitrators, which will choose the resolution requested by one of the Parties (or if the Panel desires, offers a resolution other than either resolution requested by the Parties), together with a statement in reasonable detail of the
reasons therefor. The Panel is not empowered to award punitive damages. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>10.3 Disputes About the Arbitration.</B> All
disputes relating to the proper execution of the Arbitration (including, without limitation, failure of a Party to comply with the timing or other requirements of the arbitration or the fairness or appropriateness of an arbitrator) shall be finally
settled in a binding manner on both Parties by a retired federal court judge or, if not available, some other experienced professional adjudicator or arbitrator appointed by the President or other senior executive of the American Arbitration
Association (such retired judge, adjudicator, or arbitrator, a &#147;<B>Referee</B>&#148;) in an expedited hearing not to exceed one full business day (&#147;<B>Referee Hearing</B>&#148;) within fifteen (15)&nbsp;days of invocation in writing by
either Party. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>10.4 Fees and Costs of the Arbitration.</B> Each Party shall bear its own costs of the Arbitration
(including any Referee Hearing), but will share equally for payment of the fees and costs of the Panel and of any Referee. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>10.5 Waivers or Alterations to the Dispute Resolution Procedure.</B> The Parties may mutually agree in writing to waive or alter
aspects of these Arbitration provisions in any Arbitration. The time limits provided in this <B>Article X</B> may be waived or altered in case of serious hardship or inconvenience on the part of any Arbitrator or Referee, provided that any such
waiver or alteration be minimized to the extent possible in accordance with the intent of the Parties at the time of the execution and delivery of this Agreement that the Arbitration procedure yield expedited resolutions. In addition, in the event
of any breach or threatened breach of Section&nbsp;6.3, the nonbreaching Party will be entitled to seek equitable relief in any Federal District Court of competent jurisdiction in addition to its other available legal remedies without submitting
such matter to arbitration. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>10.6 Arbitration Confidentiality.</B> All aspects of the Arbitration and any Referee Hearing,
including the Decision, shall be confidential, and all participants including the Panel and the Referee shall be bound by judicially enforceable obligations of strict confidentiality except to the extent the Parties agree in writing to waive in
whole or part such confidentiality. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>10.7 Jurisdiction.</B> The Parties agree to accept the jurisdiction of the Federal
District Courts for the purposes of enforcing the mandatory arbitration provisions of this Article, including a Decision by a Panel. </FONT></P>
 <p STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">Clinical Trial
Collaboration Agreement&#151;Confidential&#151;Page 18 </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">[ * ] = Certain confidential information contained in this document, marked by
brackets, is filed with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. </FONT></P>


<p Style='page-break-before:always'>
<HR  SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>ARTICLE XI </B></FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>MISCELLANEOUS </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>11.1 Assignment. </B></FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>Neither Party may assign its rights or obligations under this Agreement without the prior written consent of the other Party;
provided, however, that upon prior written notice to the other Party, either Party may assign any of its rights or obligations under this Agreement to any Affiliates of such Party; and to an entity that acquires all or substantially all of the
business or assets of ARCA or Medtronic to which this Agreement pertains (including by way of merger, consolidation, reorganization, acquisition, sale or otherwise) and such entity agrees to be bound by the terms and conditions of this Agreement. In
any assignment of this Agreement to an Affiliate of a Party, the assigning Party shall remain responsible to be guarantor of the performance by its Affiliates and shall cause its Affiliates to comply with the provisions of this Agreement in
connection with such performance. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>Subject to the foregoing, this Agreement shall be binding upon and inure to the
benefit of the successors and permitted assigns of the Parties. Any assignment not in accordance with this Agreement shall be null and void and of no effect. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>11.2 Costs and Expenses.</B> Except as otherwise provided in this Agreement, or as agreed to from time to time by the Parties, each Party shall bear all of its own costs and expenses, including legal
and other advisory fees, incurred in connection with negotiating and performing its respective obligations under this Agreement. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>11.3 Force Majeure.</B> Neither Party shall lose any rights hereunder or be liable to the other Party for damages or losses on account of failure of performance by the defaulting Party if the failure
is occasioned by government action, war, fire, explosion, flood, strike, lockout, embargo, act of God, or other cause beyond the reasonable control of the defaulting Party, provided that the Party claiming force majeure has exerted commercially
reasonable efforts to avoid or remedy such force majeure, provided that in no event shall a Party be required to settle any labor dispute or disturbance, provided that the Party claiming a force majeure event promptly gives written notice of the
event to the other Party. If a force majeure event remains unresolved for more than 60 days, the other Party may terminate this Agreement upon at least 30 days written notice. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>11.4 Further Actions.</B> Each Party agrees to execute, acknowledge, and deliver such further instruments, and to do all such other acts, as may be necessary or appropriate in order to carry out the
purposes and intent of this Agreement. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>11.5 No Trademark Rights.</B> No right, express or implied, is granted by the
Agreement to use in any manner the name &#147;Medtronic,&#148; &#147;ARCA&#148; or any other trade name or trademarks of the other Party or its Affiliates in connection with the performance of this Agreement. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>11.6 Notices.</B> All notices hereunder shall be in writing and shall be deemed given when delivered in one of the following ways:
three business days after being mailed by registered or certified mail (return receipt requested), postage prepaid; or the next business day after being sent by express courier service (next business day delivery provided), to the Parties at the
following addresses (or at such other address for a party as shall be specified by like notice. </FONT></P>
 <p STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">Clinical Trial
Collaboration Agreement&#151;Confidential&#151;Page 19 </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">[ * ] = Certain confidential information contained in this document, marked by
brackets, is filed with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. </FONT></P>


<p Style='page-break-before:always'>
<HR  SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

 <DIV ALIGN="right">
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="96%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE">


<TR>
<TD WIDTH="51%"></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD WIDTH="47%"></TD></TR>


<TR>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">If to ARCA, addressed to:</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">ARCA biopharma, Inc.</FONT></TD></TR>
<TR>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">8001 Arista Place, Suite 430</FONT></TD></TR>
<TR>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Broomfield, Colorado 80021</FONT></TD></TR>
<TR>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Attention: Chief Executive Officer</FONT></TD></TR>
<TR>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Telephone: (720) 940-2100</FONT></TD></TR>
<TR>
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD></TR>
<TR>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">If to Medtronic, addressed to:</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Medtronic, Inc.</FONT></TD></TR>
<TR>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">8200 Coral Sea Street NE</FONT></TD></TR>
<TR>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Mounds View, MN 55112</FONT></TD></TR>
<TR>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Attention: General Manager, CRDM Diagnostics</FONT></TD></TR>
<TR>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Telephone: 763 526-0216</FONT></TD></TR>
<TR>
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD></TR>
<TR>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">With a copy to:</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Medtronic, Inc.</FONT></TD></TR>
<TR>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">8200 Coral Sea Street NE (MVC42)</FONT></TD></TR>
<TR>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Mounds View, MN 55112</FONT></TD></TR>
<TR>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Attn: CRDM Legal Team Leader</FONT></TD></TR>
<TR>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Telephone: 763 526-1252</FONT></TD></TR>
</TABLE></DIV> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>11.7 Waiver.</B> Waiver by either of the Parties of any of their rights or their failure to
exercise any remedy shall not be effective unless in writing signed by the waiving Party and shall not operate or be construed as a continuing waiver of same or of any other of such Party&#146;s rights or remedies provided in this Agreement.
</FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>11.8 Severability.</B> If any term, covenant, or condition of this Agreement or the application thereof to any Party or
circumstance shall, to any extent, be held to be invalid or unenforceable, then (i)&nbsp;the remainder of this Agreement, or the application of such term, covenant, or condition to Parties or circumstances other than those as to which it is held
invalid or unenforceable, shall not be affected thereby and each term, covenant, or condition of this Agreement shall be valid and be enforced to the fullest extent permitted by law; and (ii)&nbsp;the Parties hereto covenant and agree to renegotiate
any such term, covenant, or application thereof in good faith in order to provide a reasonably acceptable alternative to the term, covenant, or condition of this Agreement or the application thereof that is invalid or unenforceable, it being the
intent of the Parties that the basic purposes of this Agreement are to be effectuated. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>11.9 Ambiguities.</B> Ambiguities,
if any, in this Agreement shall not be construed against any Party, irrespective of which Party may be deemed to have authored the ambiguous provision. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>11.10 Counterparts.</B> This Agreement may be executed in two or more counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument.
</FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>11.11 Days.</B> Unless otherwise explicitly stated herein, a reference in this Agreement to a number of days means
calendar days. As used in this Agreement, &#147;business day&#148; refers to any day other than a Saturday or Sunday. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>11.12 Governing Law.</B> This Agreement, and any dispute or controversy arising out of or relating thereto, shall in all respects be
governed by and construed according to the laws of the State of Minnesota (excluding its conflicts of law principles). </FONT></P>
 <p STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">Clinical Trial
Collaboration Agreement&#151;Confidential&#151;Page 20 </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">[ * ] = Certain confidential information contained in this document, marked by
brackets, is filed with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. </FONT></P>


<p Style='page-break-before:always'>
<HR  SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>11.13 Entire Agreement.</B> This Agreement sets forth all the covenants, promises,
agreements, warranties, representations, conditions and understandings between the Parties hereto and supersedes and terminates all prior agreements and understandings between the Parties. There are no covenants, promises, agreements, warranties,
representations, conditions, or understandings, either oral or written, between the Parties other than as set forth herein and therein. No subsequent alteration, amendment, change of addition to this Agreement shall be binding upon the Parties
hereto unless reduced to writing and signed by the respective authorized officers of the Parties. </FONT></P> <P STYLE="margin-top:24px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>[Remainder of Page
Intentionally Blank] </B></FONT></P>
 <p STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">Clinical Trial
Collaboration Agreement&#151;Confidential&#151;Page 21 </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">[ * ] = Certain confidential information contained in this document, marked by
brackets, is filed with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. </FONT></P>


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<HR  SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">IN WITNESS WHEREOF, the Parties hereto have caused this Agreement to be executed by their
duly authorized representatives as of the day and year first above written. </FONT></P> <P STYLE="font-size:12px;margin-top:0px;margin-bottom:0px">&nbsp;</P><DIV ALIGN="right">
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="40%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE">


<TR>
<TD WIDTH="4%"></TD>
<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="95%"></TD></TR>


<TR>
<TD VALIGN="top" COLSPAN="3"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>MEDTRONIC,&nbsp;INC.,&nbsp;a&nbsp;Minnesota&nbsp;corporation</B></FONT></P></TD></TR>
<TR>
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR>
<TD VALIGN="top"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">By:</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="top"> <P STYLE="margin-top:0px;margin-bottom:1px;border-bottom:1px solid #000000"><FONT STYLE="font-family:Times New Roman" SIZE="2">/s/ Richard L. Clark</FONT></P></TD></TR>
<TR>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="top"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Richard L. Clark</FONT></P></TD></TR>
<TR>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="top"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Senior Director</FONT></P></TD></TR>
<TR>
<TD HEIGHT="16" COLSPAN="3"></TD></TR>
<TR>
<TD VALIGN="top" COLSPAN="3"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>ARCA&nbsp;BIOPHARMA,&nbsp;INC.,&nbsp;a&nbsp;Delaware&nbsp;corporation</B></FONT></P></TD></TR>
<TR>
<TD HEIGHT="20"></TD>
<TD HEIGHT="20" COLSPAN="2"></TD></TR>
<TR>
<TD VALIGN="top"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">By:</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="top"> <P STYLE="margin-top:0px;margin-bottom:1px;border-bottom:1px solid #000000"><FONT STYLE="font-family:Times New Roman" SIZE="2">/s/ Michael R. Bristow</FONT></P></TD></TR>
<TR>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="top"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Michael Bristow</FONT></P></TD></TR>
<TR>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="top"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Chief Executive Officer</FONT></P></TD></TR>
</TABLE></DIV>
 <p STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">Clinical Trial
Collaboration Agreement&#151;Confidential&#151;Page 22 </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">[ * ] = Certain confidential information contained in this document, marked by
brackets, is filed with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. </FONT></P>


<p Style='page-break-before:always'>
<HR  SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">APPENDIX A </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px" ALIGN="center"><FONT
STYLE="font-family:Times New Roman" SIZE="2">GENETIC-AF STUDY </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">The GENETIC-AF Study shall include the following elements as
part of the study protocol; provided, that ARCA may amend Appendix A from time to time as determined by the Steering Committee. </FONT></P> <P STYLE="font-size:12px;margin-top:0px;margin-bottom:0px">&nbsp;</P>
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<TR>
<TD WIDTH="35%"></TD>
<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="32%"></TD>
<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="31%"></TD></TR>


<TR>
<TD VALIGN="top" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Name of Sponsor/Company<BR></B>ARCA biopharma, Inc.<B></B></FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="top" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Name of Test Product<BR></B>Gencaro&#153;<B></B></FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="top" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Name of Active Ingredient<BR></B>bucindolol hydrochloride<B></B></FONT></TD></TR>
<TR>
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>IND / Protocol Number<BR></B>16,463 / BUC-CLIN-303<B></B></FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="top" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Phase / Indication<BR></B>Phase 2B-3 / Atrial Fibrillation<B></B></FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="top" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Version / Date<BR></B>Draft v6 / 10&nbsp;April 2013<B></B></FONT></TD></TR>
</TABLE> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Title of Study:</B> GENETIC-AF: A <B><U>Gen</U></B>otype-Directed Comparative <B><U>E</U></B>ffectiveness
<B><U>T</U></B>r<B><U>i</U></B>al of Bu<B><U>c</U></B>indolol and Metoprolol CR/XL for the Prevention of Recurrent Symptomatic <B><U>A</U></B>trial <B><U>F</U></B>ibrillation in Patients with Heart Failure. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Study Rationale: </B>Most anti-arrhythmic agents currently approved for the treatment of atrial fibrillation (AF) are either contraindicated or have
label warnings for use in heart failure patients due to an increased risk of mortality in this patient population. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px;padding-bottom:0px; "><FONT STYLE="font-family:Times New Roman" SIZE="2">Bucindolol hydrochloride (bucindolol) is a nonselective &szlig;-adrenergic receptor (&szlig;-AR) blocking agent with mild
vasodilator properties, which was previously studied in the BEST Phase 3 heart failure trial. In a large pharmacogenomic substudy of the BEST trial, two unique pharmacologic properties of bucindolol, sympatholysis and inverse agonism, were shown to
interact with adrenergic receptor polymorphisms in such a way that targeting specific genotypes of these variants could improve therapeutic index. Specifically, patients with the &szlig;</FONT><FONT STYLE="font-family:Times New Roman" SIZE="1"><SUB
STYLE="vertical-align:baseline; position:relative; top:.4ex">1</SUB></FONT><FONT STYLE="font-family:Times New Roman" SIZE="2">389Arg/Arg AR variant had more efficacious treatment responses to bucindolol, as assessed by HF clinical outcomes and the
reduction of new onset AF, compared to patients with the &szlig;</FONT><FONT STYLE="font-family:Times New Roman" SIZE="1"><SUB STYLE="vertical-align:baseline; position:relative; top:.4ex">1</SUB></FONT><FONT
STYLE="font-family:Times New Roman" SIZE="2">389 Gly polymorphism (i.e., Gly carriers). </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px;padding-bottom:0px; "><FONT STYLE="font-family:Times New Roman" SIZE="2">Metoprolol succinate (metoprolol
CR/XL) is a &szlig;</FONT><FONT STYLE="font-family:Times New Roman" SIZE="1"><SUB STYLE="vertical-align:baseline; position:relative; top:.4ex">1</SUB></FONT><FONT STYLE="font-family:Times New Roman" SIZE="2">-adrenergic receptor (AR) selective beta
blocker indicated for the treatment of stable, symptomatic (NYHA Class II or III) heart failure of ischemic or nonischemic origin. Metoprolol has demonstrated mild efficacy for the prevention of new onset AF in a heart failure patient population and
is often used off-label in this setting (Class IIa indication with a &#147;C&#148; level of evidence for AF prevention per ACC/AHA/ESC joint Guidelines). In a previous study, metoprolol decreased the incidence of AF recurrence, compared to placebo,
in patients with persistent AF who had recently undergone electrical cardioversion (ECV) to sinus rhythm. In contrast to bucindolol, metoprolol CR/XL does not appear to confer added clinical benefits in patients that possess the &szlig;</FONT><FONT
STYLE="font-family:Times New Roman" SIZE="1"><SUB STYLE="vertical-align:baseline; position:relative; top:.4ex">1</SUB></FONT><FONT STYLE="font-family:Times New Roman" SIZE="2">389Arg/Arg AR variant. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px;padding-bottom:0px; "><FONT STYLE="font-family:Times New Roman" SIZE="2">The goal of the GENETIC-AF trial is to demonstrate the superiority of pharmacogenetically targeted bucindolol compared to metoprolol
therapy for the prevention of symptomatic AF in a genotype-defined &szlig;</FONT><FONT STYLE="font-family:Times New Roman" SIZE="1"><SUB STYLE="vertical-align:baseline; position:relative; top:.4ex">1</SUB></FONT><FONT
STYLE="font-family:Times New Roman" SIZE="2">389Arg/Arg heart failure population with persistent AF that has recently undergone cardioversion to sinus rhythm.<B> </B>The trial utilizes an adaptive design, with initial enrollment of 200 patients who
will have their rhythm continuously monitored through inserted or implanted devices to measure AF burden (AFB) in addition to the other study endpoints. If the independent Data Safety Monitoring Committee (DSMB) determines that an efficacy signal
favorable to bucindolol has been detected by AFB and/or the primary endpoint, the trial will proceed to full enrollment of approximately 620 patients. </FONT></P>
 <p STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">[ * ] = Certain confidential
information contained in this document, marked by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. </FONT></P>


<p Style='page-break-before:always'>
<HR  SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

 <P STYLE="margin-top:0px;margin-bottom:0px;padding-bottom:0px; "><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Objectives:</B> The primary objective of this study is to compare the effects of
bucindolol hydrochloride (bucindolol) and metoprolol CR/XL on the recurrence of symptomatic AF in patients with chronic heart failure and reduced LV ejection fraction (HFREF) who are &szlig;</FONT><FONT STYLE="font-family:Times New Roman" SIZE="1"><SUB
STYLE="vertical-align:baseline; position:relative; top:.4ex">1</SUB></FONT><FONT STYLE="font-family:Times New Roman" SIZE="2">389Arg/Arg homozygous and have undergone cardioversion to sinus rhythm. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px;padding-bottom:0px; "><FONT STYLE="font-family:Times New Roman" SIZE="2">The secondary objectives of this study are to compare the effects of bucindolol and metoprolol CR/XL on clinical outcomes and other
electrocardiograph parameters in patients with HFREF who are &szlig;</FONT><FONT STYLE="font-family:Times New Roman" SIZE="1"><SUB STYLE="vertical-align:baseline; position:relative; top:.4ex">1</SUB></FONT><FONT
STYLE="font-family:Times New Roman" SIZE="2">389Arg/Arg homozygous and have undergone cardioversion to sinus rhythm, and to assess the effects on rate control in patients who have developed permanent AF. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">The safety and tolerability of bucindolol hydrochloride and metoprolol CR/XL will also be evaluated. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Study Design:</B> GENETIC-AF is a double-blind, two-arm, genotype-directed, active-controlled, adaptive-designed, superiority study that compares the
effects of bucindolol and metoprolol CR/XL on the time to first event of symptomatic recurrent AF in patients with HFREF who have recently undergone cardioversion to sinus rhythm. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px;padding-bottom:0px; "><FONT STYLE="font-family:Times New Roman" SIZE="2">[ * ] Patients will be genotyped for &szlig;</FONT><FONT STYLE="font-family:Times New Roman" SIZE="1"><SUB
STYLE="vertical-align:baseline; position:relative; top:.4ex">1</SUB></FONT><FONT STYLE="font-family:Times New Roman" SIZE="2">389 AR at screening and those who are &szlig;</FONT><FONT STYLE="font-family:Times New Roman" SIZE="1"><SUB
STYLE="vertical-align:baseline; position:relative; top:.4ex">1</SUB></FONT><FONT STYLE="font-family:Times New Roman" SIZE="2">389Arg/Arg (~50% of patients) will be eligible for participation in the study. </FONT></P>
<P STYLE="margin-top:6px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">[ * ] </FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">[ * ] </FONT></P>
<P STYLE="margin-top:6px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">[ * ] </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">The primary endpoint (i.e., time to
first event of symptomatic recurrent AF or all-cause mortality) will be assessed during the 24-week follow-up period after the initial cardioversion to stable sinus rhythm. [ * ] </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT
STYLE="font-family:Times New Roman" SIZE="2">The first 200 patients enrolled will have their cardiac rhythm monitored continuously via a Medtronic implanted device that can measure AFB, which can be previously placed or de novo inserted at the time
of enrollment. These devices will record AF burden (AFB), defined as the percent of time a patient is in AF. AFB will be used along with the primary endpoint to provide the DSMB with information relative to the presence or absence of an efficacy
signal in the initial patient cohort. If the DSMB determines that an efficacy signal favorable to bucindolol has been detected by AFB and/or the primary endpoint, the trial will proceed to full enrollment of approximately 620 patients. If the DSMB
determines that insufficient efficacy has been observed, patients will be instructed to return to the clinic for an end of study visit and the trial will be terminated. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px;padding-bottom:0px; "><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>Number of Patients: </B>A total of 200 patients will be enrolled in the Phase 2B stage, and an additional 420 patients will be enrolled in the Phase 3 stage. The &szlig;</FONT><FONT
STYLE="font-family:Times New Roman" SIZE="1"><SUB STYLE="vertical-align:baseline; position:relative; top:.4ex">1</SUB></FONT><FONT STYLE="font-family:Times New Roman" SIZE="2">389Arg/Arg genotype is expected in approximately 50% of patients. [ * ]
</FONT></P>
 <p STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">[ * ] = Certain confidential
information contained in this document, marked by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. </FONT></P>


<p Style='page-break-before:always'>
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 <P STYLE="margin-top:0px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">[ * ] </FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px"><FONT
STYLE="font-family:Times New Roman" SIZE="2">[ * ] </FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">[ * ] </FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px"><FONT
STYLE="font-family:Times New Roman" SIZE="2">[ * ] </FONT></P> <P STYLE="margin-top:18px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Primary Efficacy Endpoint: </B></FONT></P>
<P STYLE="font-size:6px;margin-top:0px;margin-bottom:0px">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR>
<TD WIDTH="1%"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD WIDTH="2%" VALIGN="top" ALIGN="left"><FONT STYLE="font-family:Times New Roman" SIZE="2">&#149;</FONT></TD>
<TD WIDTH="1%" VALIGN="top"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD ALIGN="left" VALIGN="top"> <P ALIGN="left"><FONT STYLE="font-family:Times New Roman" SIZE="2">Time to first event of symptomatic recurrent AF or all-cause mortality during the 24-week follow-up period after cardioversion to stable sinus rhythm.
</FONT></P></TD></TR></TABLE> <P STYLE="margin-top:6px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2">[ * ] </FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px"><FONT
STYLE="font-family:Times New Roman" SIZE="2">[ * ] </FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">[ * ] </FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px"><FONT
STYLE="font-family:Times New Roman" SIZE="2">[ * ] </FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">[ * ] </FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px"><FONT
STYLE="font-family:Times New Roman" SIZE="2">[ * ] </FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">[ * ] </FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px"><FONT
STYLE="font-family:Times New Roman" SIZE="2">[ * ] </FONT></P> <P STYLE="font-size:6px;margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
 <p STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">[ * ] = Certain confidential
information contained in this document, marked by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. </FONT></P>

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 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Exhibit 99.1 </B></FONT></P>
<P STYLE="font-size:12px;margin-top:0px;margin-bottom:0px">&nbsp;</P> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="right">


<IMG SRC="g526054g43s02.jpg" ALT="LOGO">
 </P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Contact: </B></FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT
STYLE="font-family:Times New Roman" SIZE="2">Derek Cole </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">Vice President of Investor Relations </FONT></P>
<P STYLE="margin-top:0px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">720.940.2100 </FONT></P> <P STYLE="margin-top:24px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>ARCA BIOPHARMA
AND MEDTRONIC TO COLLABORATE ON ATRIAL </B></FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px;padding-bottom:0px; " ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>FIBRILLATION CLINICAL TRIAL FOR GENCARO<FONT
STYLE="font-family:Times New Roman" SIZE="1"><SUP STYLE="vertical-align:baseline; position:relative; bottom:.8ex">TM</SUP></FONT><FONT STYLE="font-family:Times New Roman" SIZE="2"> </FONT></B></FONT></P>
<P STYLE="font-size:12px;margin-top:0px;margin-bottom:0px">&nbsp;</P><center> <P STYLE="line-height:6px;margin-top:0px;margin-bottom:2px;border-bottom:1pt solid #000000;width:21%">&nbsp;</P></center>
<P STYLE="margin-top:12px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Patients in Novel Clinical Trial Will Have Cardiac Rhythms Continuously Monitored </B></FONT></P>
<P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>With Implanted Medtronic Devices </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><I>Broomfield, CO, April&nbsp;22, 2013</I> &#150; ARCA biopharma, Inc. (Nasdaq: ABIO), a biopharmaceutical company developing genetically-targeted therapies for cardiovascular diseases, today announced
that it has entered into an agreement with Medtronic, Inc. (NYSE:MDT), a leader in medical technologies to improve the treatment of chronic diseases, including cardiac rhythm disorders, to collaborate on ARCA&#146;s proposed clinical trial, known as
GENETIC-AF, of its lead developmental drug Gencaro (bucindolol hydrochloride). </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">GENETIC-AF is planned as a Phase 2b/3 clinical trial comparing
Gencaro to metoprolol CR/XL for prevention of atrial fibrillation (&#147;AF&#148;) in patients with heart failure and reduced left ventricular ejection fraction (&#147;HFREF&#148;). ARCA plans to enroll only patients with the genetic variant of the
beta-1 cardiac receptor which the Company believes responds most favorably to Gencaro. GENETIC-AF has an adaptive design, under which the Company plans to initiate it as a Phase 2b study in approximately 200 patients and then, depending on the
results of an interim analysis, expand the trial to a Phase 3 study by enrolling an estimated additional 420 patients. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px;padding-bottom:0px; "><FONT STYLE="font-family:Times New Roman" SIZE="2">Under the collaboration, ARCA plans, with the support of Medtronic, to conduct a substudy that will include continuous monitoring of
the the cardiac rhythms of all 200 patients enrolled during the Phase 2b portion of GENETIC-AF. Each patient will have heart rhythm monitoring via a Medtronic device, either a previously implanted cardiac resynchronization or defibrillation device,
or a previously or newly inserted Reveal<FONT STYLE="font-family:Times New Roman" SIZE="1"><SUP STYLE="vertical-align:baseline; position:relative; bottom:.8ex">&reg;</SUP></FONT> loop recorder. The collaboration substudy will measure AF burden,
defined as a patient&#146;s actual time in AF regardless of symptoms. In determining the presence of an efficacy signal in the Phase 2b portion of the trial AF burden will be evaluated along with time to mortality or recurrent AF, which will also be
the Phase 3 primary endpoint. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">ARCA believes that the AF burden endpoint will help provide an accurate and comprehensive assessment of each
patient&#146;s AF episodes, and will be useful in evaluating the relative efficacies of Gencaro and metoprolol CR/XL. Under the collaboration, Medtronic will support the implantation and use of the Medtronic monitoring devices, and will manage the
AF burden data collection and analysis. If GENETIC-AF proceeds to Phase 3, the parties will seek to enroll at least 100 additional patients in the AF burden substudy. </FONT></P>

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 <P STYLE="margin-top:0px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">Dr.&nbsp;Michael Bristow, MD, PhD. President and Chief Executive Officer of ARCA, said, &#147;We are excited
about our collaboration with Medtronic on GENETIC-AF. We believe that the use of implanted, continuous monitoring devices that allow for the more precise measurement of atrial fibrillation represents the next generation of diagnosis and treatment
options for patients at risk for this disease. The GENETIC-AF trial has the potential to result in an approvable new therapy that is safe and effective for HFREF patients at high risk for atrial fibrillation.&#148; </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">AF is considered an epidemic cardiovascular disease with an estimated prevalence of at least 2.7&nbsp;million Americans in 2010. The approved therapies
for the treatment or prevention AF have certain disadvantages in HFREF patients, such as toxic or cardiovascular adverse effects, and most of the approved drugs for AF are contra indicated or have warnings in their prescribing information for such
patients. ARCA believes there is an unmet medical need for new AF treatments that have fewer side effects than currently available therapies and are more effective, particularly in HFREF patients. </FONT></P>
<P STYLE="margin-top:18px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>About ARCA biopharma </B></FONT></P>
<P STYLE="margin-top:6px;margin-bottom:0px;padding-bottom:0px; "><FONT STYLE="font-family:Times New Roman" SIZE="2">ARCA biopharma is dedicated to developing genetically-targeted therapies for cardiovascular diseases. The Company&#146;s lead product
candidate, Gencaro</FONT><FONT STYLE="font-family:Times New Roman" SIZE="1"><SUP STYLE="vertical-align:baseline; position:relative; bottom:.8ex">TM</SUP></FONT><FONT STYLE="font-family:Times New Roman" SIZE="2"> (bucindolol hydrochloride), is an
investigational, pharmacologically unique beta-blocker and mild vasodilator being developed for atrial fibrillation. ARCA has identified common genetic variations that it believes predict individual patient response to Gencaro, giving it the
potential to be the first genetically-targeted atrial fibrillation prevention treatment. ARCA has a collaboration with the Laboratory Corporation of America (LabCorp), under which LabCorp has developed a companion genetic test for Gencaro. For more
information please visit <U>www.arcabiopharma.com</U>. </FONT></P> <P STYLE="margin-top:18px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Safe Harbor Statement </B></FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px"><FONT
STYLE="font-family:Times New Roman" SIZE="2">This press release contains &#147;forward-looking statements&#148; for purposes of the safe harbor provided by the Private Securities Litigation Reform Act of 1995. These statements include, but are not
limited to, statements regarding the potential for genetic variations to predict individual patient response to Gencaro, Gencaro&#146;s potential to treat atrial fibrillation, future treatment options for patients with atrial fibrillation, the role
of AF burden in diagnosis and treatment of atrial fibrillation and the potential for Gencaro to be the first genetically-targeted atrial fibrillation prevention treatment. Such statements are based on management&#146;s current expectations and
involve risks and uncertainties. Actual results and performance could differ materially from those projected in the forward-looking statements as a result of many factors, including, without limitation, the risks and uncertainties associated with:
the Company&#146;s financial resources and whether they will be sufficient to meet the Company&#146;s business objectives and operational requirements; results of earlier clinical trials may not be confirmed in future trials, the protection and
market exclusivity provided by the Company&#146;s intellectual property; risks related to the drug discovery and the regulatory approval process; and, the impact of competitive products and technological changes. These and other factors are
identified and described in more detail in ARCA&#146;s filings with the SEC, including without limitation the Company&#146;s annual report on Form 10-K for the year ended December&nbsp;31, 2012, the Company&#146;s Registration Statement on Form S-1
(Registration No.&nbsp;333-187508), and subsequent filings. The Company disclaims any intent or obligation to update these forward-looking statements. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px" ALIGN="center"><FONT
STYLE="font-family:Times New Roman" SIZE="2">### </FONT></P>
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`
end
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
