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Commitments and Contingencies (Details Textual) (USD $) | 1 Months Ended | 12 Months Ended | 144 Months Ended | 12 Months Ended |  |  | 12 Months Ended |
--- | --- | --- | --- | --- | --- | --- | --- | ---
Jul. 31, 2008 | Dec. 31, 2013 | Dec. 31, 2012 | Dec. 31, 2013 | Dec. 31, 2013 Broomfield, Colorado | Jun. 30, 2011 Broomfield, Colorado sqft | Aug. 08, 2008 Broomfield, Colorado sqft | Dec. 31, 2013 Westminster, Colorado | Aug. 01, 2013 Westminster, Colorado sqft
Commitments and Contingencies (Textual) [Abstract] |  |  |  |  |  |  |  |  |
Area of office facilities taken on lease |  |  |  |  |  | 4,500 | 15,000 |  | 5,300
Lease term |  |  |  |  | 5 years |  |  | 3 years |
Lease expiry period |  |  |  |  | 2013-09 |  |  | 2016-09 |
Milestone payment | $ 500,000 |  |  |  |  |  |  |  |
Expected milestone payments upon approval | 8,000,000 |  |  |  |  |  |  |  |
Another expected milestone payments upon approval | 5,000,000 |  |  |  |  |  |  |  |
Minimum percentage of royalty obligation | 12.50% |  |  |  |  |  |  |  |
Maximum percentage of royalty obligation | 25.00% |  |  |  |  |  |  |  |
Product sales levels royalty | 5.00% |  |  |  |  |  |  |  |
Minimum percentage of range of royalties that can be buy down | 12.50% |  |  |  |  |  |  |  |
Maximum percentage of range of royalties that can be buy down | 17.00% |  |  |  |  |  |  |  |
Milestone payment due period | 6 months |  |  |  |  |  |  |  |
Clinical research agreement with Duke University, termination notice period |  | 90 days |  |  |  |  |  |  |
Rent expense |  | $ 63,000 | $ 48,000 | $ 578,000 |  |  |  |  |

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