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Consolidated Statements of Preferred Stock and Stockholders' Equity (Deficit) (USD $) In Thousands, except Share data | Total USD ($) | Series A Convertible Preferred Stock USD ($) | Common Stock USD ($) | Additional Paid-in Capital USD ($) | Deficit Accumulated During Development Stage USD ($) | Issuance for Notes Payable and Related Accrued Interest on January 3, 2005 USD ($) | Issuance for Notes Payable and Related Accrued Interest on January 3, 2005 Common Stock | Issuance for Notes Payable and Related Accrued Interest on January 3, 2005 Additional Paid-in Capital USD ($) | Issuance for Intellectual Property License Rights on October 14, 2005 USD ($) | Issuance for Intellectual Property License Rights on October 14, 2005 Common Stock | Issuance for Intellectual Property License Rights on October 14, 2005 Additional Paid-in Capital USD ($) | Issuance for Notes Payable and Related Accrued Interest on October 14, 2005 USD ($) | Issuance for Notes Payable and Related Accrued Interest on October 14, 2005 Common Stock | Issuance for Notes Payable and Related Accrued Interest on October 14, 2005 Additional Paid-in Capital USD ($) | Issuance for Intellectual Property License Rights on February 21, 2006 USD ($) | Issuance for Intellectual Property License Rights on February 21, 2006 Common Stock | Issuance for Intellectual Property License Rights on February 21, 2006 Additional Paid-in Capital USD ($) | Issuance for Intellectual Property License Rights on February 22, 2006 USD ($) | Issuance for Intellectual Property License Rights on February 22, 2006 Common Stock | Issuance for Intellectual Property License Rights on February 22, 2006 Additional Paid-in Capital USD ($) | Issuance for Intellectual Property License Rights on June 23, 2006 USD ($) | Issuance for Intellectual Property License Rights on June 23, 2006 Common Stock | Issuance for Intellectual Property License Rights on June 23, 2006 Additional Paid-in Capital USD ($) | Issuance for Intellectual Property License Rights on November 7, 2006 Common Stock | Accretion of Series A USD ($) | Accretion of Series A Additional Paid-in Capital USD ($) | Accretion of Series B USD ($) | Accretion of Series B Additional Paid-in Capital USD ($) | Issuance for Intellectual Property License Rights on January 18, 2007 USD ($) | Issuance for Intellectual Property License Rights on January 18, 2007 Common Stock | Issuance for Intellectual Property License Rights on January 18, 2007 Additional Paid-in Capital USD ($) | Issuance for Intellectual Property License Rights on June 30, 2007 USD ($) | Issuance for Intellectual Property License Rights on June 30, 2007 Common Stock | Issuance for Intellectual Property License Rights on June 30, 2007 Additional Paid-in Capital USD ($) | Issuance of Common Stock for Commercial License Rights, on July 19, 2007 Common Stock | Issuance of Shares to Executive Subject to Repurchase Common Stock | Common Conversion USD ($) | Common Conversion Common Stock USD ($) | Common Conversion Additional Paid-in Capital USD ($) | Notes and Related Accrued Interest Common Stock | Cash, Net of Offering Costs USD ($) | Cash, Net of Offering Costs Series A Convertible Preferred Stock USD ($) | Cash, Net of Offering Costs Common Stock USD ($) | Cash, Net of Offering Costs Additional Paid-in Capital USD ($) | Cash, Net of Offering Costs Deficit Accumulated During Development Stage USD ($) | Series A USD ($) | Series A Series A offering costs USD ($) | Series A Issuance of Series A on February 22, 2006 USD ($) | Series A Third Issuance For Notes Payable And Related Accrued Interest USD ($) | Series A Redeemable Convertible Preferred Stock USD ($) | Series A Accretion of Series A USD ($) | Series A Common Conversion USD ($) | Series A Cash, Net of Offering Costs USD ($) | Series B USD ($) | Series B Third Issuance Of Series B Convertible Redeemable Preferred Stock USD ($) | Series B Issuance for Series B on December 28, 2007 USD ($) | Series B Accretion of Series B USD ($) | Series B Common Conversion USD ($) | Series B Cash, Net of Offering Costs USD ($)
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Beginning Balance, value at Dec. 17, 2001 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Beginning Balance, shares at Dec. 17, 2001 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of equity for cash or intellectual property rights, value | 1 |  |  | 1 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of equity for cash or intellectual property rights, shares |  |  | 2,588 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net loss | (116) |  |  |  | (116) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ending Balance, value at Dec. 31, 2003 | (115) |  |  | 1 | (116) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ending Balance, shares at Dec. 31, 2003 |  |  | 2,588 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of equity for cash or intellectual property rights, value | 7 |  |  | 7 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of equity for cash or intellectual property rights, shares |  |  | 19,720 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net loss | (511) |  |  |  | (511) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ending Balance, value at Dec. 31, 2004 | (619) |  |  | 8 | (627) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ending Balance, shares at Dec. 31, 2004 |  |  | 22,308 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of equity for cash or intellectual property rights, value | 1 |  |  | 1 |  | 1 |  | 1 | 44 |  | 44 | 1,354 |  | 1,354 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of equity for cash or intellectual property rights, shares |  |  | 2,922 |  |  |  | 2,978 |  |  | 903 |  |  | 31,095 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net loss | (1,459) |  |  |  | (1,459) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ending Balance, value at Dec. 31, 2005 | (678) |  |  | 1,408 | (2,086) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ending Balance, shares at Dec. 31, 2005 |  |  | 60,206 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of equity for cash or intellectual property rights, value |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 75 |  | 75 | 60 |  | 60 | 15 |  | 15 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 9,316 |  | 5,000 |  |  |  |  |  |  |  |  |
Issuance of equity for cash or intellectual property rights, shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 17,372 |  |  | 13,907 |  |  | 2,505 |  | 38 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 5,727,354 |  | 3,074,086 |  |  |  |  |  |  |  |  |
Share-based compensation | 39 |  |  | 39 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net loss | (5,241) |  |  |  | (5,241) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Offering Costs | (17) |  |  | (17) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 17 | (98) |  |  |  |  |  |  |  |  |  |  |  |
Issuance of preferred stock upon conversion of note payable and accrued interest, value |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 684 |  |  |  |  |  |  |  |  |  |
Issuance of preferred stock upon conversion of note payable and accrued interest, shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 420,817 |  |  |  |  |  |  |  |  |  |
Issuance of common stock upon exercise of stock options, for cash, value | 3 |  |  | 3 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock upon exercise of stock options, for cash, shares |  |  | 8,019 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ending Balance, value at Dec. 31, 2006 | (5,744) |  |  | 1,583 | (7,327) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 14,919 |  |  |  |  |  |  |  |  |  |  |  |  |
Ending Balance, shares at Dec. 31, 2006 |  |  | 102,047 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 9,222,257 |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of equity for cash or intellectual property rights, value |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 13 |  | 13 | 7 |  | 7 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 9,000 | 9,000 |  |  |
Issuance of equity for cash or intellectual property rights, shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,303 |  |  | 642 |  | 2,783 | 13,915 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 3,688,902 | 2,766,677 |  |  |
Share-based compensation | 50 |  |  | 50 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net loss | (13,994) |  |  |  | (13,994) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Offering Costs |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (19) | (19) | (18) | (18) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 19 |  |  | (147) |  |  | 18 |  |
Issuance of common stock upon exercise of stock options, for cash, value | 16 |  |  | 16 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock upon exercise of stock options, for cash, shares |  |  | 2,227 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ending Balance, value at Dec. 31, 2007 | (19,689) |  |  | 1,632 | (21,321) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 14,938 |  |  |  |  |  |  |  | 17,871 |  |  |  |  |
Ending Balance, shares at Dec. 31, 2007 |  |  | 122,917 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 9,222,257 |  |  |  |  |  |  |  | 6,455,579 |  |  |  |  |
Share-based compensation | 545 |  |  | 545 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net loss | (19,431) |  |  |  | (19,431) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Offering Costs |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (20) | (20) | (36) | (36) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 20 |  |  |  |  |  | 36 |  |
Issuance of common stock upon exercise of stock options, for cash, value | 54 |  |  | 54 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock upon exercise of stock options, for cash, shares |  |  | 36,154 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Estimated fair value of warrants issued in connection with convertible notes payable | 399 |  |  | 399 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ending Balance, value at Dec. 31, 2008 | (38,178) |  |  | 2,574 | (40,752) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 14,958 |  |  |  |  |  |  |  | 17,907 |  |  |  |  |
Ending Balance, shares at Dec. 31, 2008 |  |  | 159,071 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 9,222,257 |  |  |  |  |  |  |  | 6,455,579 |  |  |  |  |
Adjustment for fractional shares |  |  | (102) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (7) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Deemed preferred stock dividend for additional common shares issuable under anti-dilution provision | (781) |  |  | (781) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 781 |  |  |  |  |
Conversion of convertible securities |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 33,781 | 1 | 33,780 |  |  |  |  |  |  |  |  |  |  |  |  | (15,000) |  |  |  |  |  | (18,781) |
Conversion of convertible notes, shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 145,465 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Merger with Nuvelo, Inc., value | 11,913 |  |  | 11,913 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Merger with Nuvelo, Inc., shares |  |  | 447,826 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock under employee stock purchase plan and upon vesting of restricted stock units, value | 2 |  |  | 2 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock under employee stock purchase plan and upon vesting of restricted stock units, shares |  |  | 177 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based compensation |  |  |  | 845 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net loss | (9,138) |  |  |  | (9,138) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Offering Costs |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (42) | (42) | (93) | (93) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 42 |  |  |  |  |  | 93 |  |
Issuance of common stock upon exercise of stock options, for cash, value | 114 |  |  | 114 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock upon exercise of stock options, for cash, shares |  |  | 10,521 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Conversion of preferred stock, shares |  |  | 507,123 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (9,222,257) |  |  |  |  |  |  |  | (6,455,579) |  |  |  |  |
Restricted stock release from restriction | 75 |  |  | 75 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Conversion of convertible notes and related accrued interest | 8,501 |  |  | 8,501 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Conversion of warrants for preferred stock | 36 |  |  | 36 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Estimated fair value of warrants issued in connection with lease termination | 377 |  |  | 377 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ending Balance, value at Dec. 31, 2009 | 7,412 |  | 1 | 57,301 | (49,890) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ending Balance, shares at Dec. 31, 2009 |  |  | 1,270,074 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of equity for cash or intellectual property rights, value |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 7,182 |  |  | 7,182 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of equity for cash or intellectual property rights, shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 194,100 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based compensation | 458 |  |  | 458 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net loss | (8,420) |  |  |  | (8,420) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock upon exercise of stock options, for cash, value | 139 |  |  | 139 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock upon exercise of stock options, for cash, shares |  |  | 8,248 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ending Balance, value at Dec. 31, 2010 | 6,771 |  | 1 | 65,080 | (58,310) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ending Balance, shares at Dec. 31, 2010 |  |  | 1,472,422 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of equity for cash or intellectual property rights, value |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 4,017 |  | 1 | 4,016 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of equity for cash or intellectual property rights, shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 557,890 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based compensation | 308 |  |  | 308 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net loss | (5,364) |  |  |  | (5,364) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock upon exercise of stock options, for cash, value |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock upon exercise of stock options, for cash, shares |  |  | 188 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ending Balance, value at Dec. 31, 2011 | 5,732 |  | 2 | 69,404 | (63,674) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ending Balance, shares at Dec. 31, 2011 |  |  | 2,030,500 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of equity for cash or intellectual property rights, value | 1,189 |  | 1 | 1,188 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of equity for cash or intellectual property rights, shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 629,815 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based compensation | 306 |  |  | 306 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net loss | (4,320) |  |  |  | (4,320) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock upon exercise of stock options, for cash, value |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ending Balance, value at Dec. 31, 2012 | 2,907 |  | 3 | 70,898 | (67,994) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ending Balance, shares at Dec. 31, 2012 |  |  | 2,660,315 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Adjustment for fractional shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (64) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Conversion of convertible securities |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (20) | 13 | (33) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of equity for cash or intellectual property rights, value |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,421 |  |  | 1,421 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of equity for cash or intellectual property rights, shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 521,066 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based compensation | 283 |  |  | 283 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net loss | (6,939) |  |  |  | (6,939) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Conversion of preferred stock, shares |  | (125,000) | 12,500,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock upon exercise of warrants for cash, value | 12 |  |  | 12 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock upon exercise of warrants for cash, share |  |  | 4,245 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of Series A convertible preferred stock, net of offering costs, Shares | 17,917 | 125,000 |  | 17,917 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of Series A convertible preferred stock, net of offering costs, Value |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Deemed preferred stock dividend for beneficial conversion feature | 2,026 |  |  | 2,026 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Impact of deemed preferred stock dividend for beneficial conversion feature on common stockholders | (2,026) |  |  | (2,026) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ending Balance, value at Dec. 31, 2013 | 15,581 |  | 16 | 90,498 | (74,933) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ending Balance, shares at Dec. 31, 2013 |  |  | 15,685,562 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of equity for cash or intellectual property rights, value |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 7,866 |  | 5 | 7,861 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of equity for cash or intellectual property rights, shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 5,116,228 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based compensation | 158 |  |  | 158 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net loss | (2,389) |  |  |  | (2,389) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock upon exercise of stock options, for cash, value | 318 |  |  | 318 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock upon exercise of stock options, for cash, shares |  |  | 199,900 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ending Balance, value at Mar. 31, 2014 | $ 21,534 |  | $ 21 | $ 98,835 | $ (77,322) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ending Balance, shares at Mar. 31, 2014 |  |  | 21,001,690 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

X
- Definition Accretion of offering cost effect on equity. + References No definition available. + Details
Name: | abio_AccretionOfOfferingCostEffectOnEquity
Namespace Prefix: | abio_
Data Type: | xbrli:monetaryItemType
Balance Type: | credit
Period Type: | duration

X
- Definition Adjustment for fractional shares. + References No definition available. + Details
Name: | abio_AdjustmentForFractionalShares
Namespace Prefix: | abio_
Data Type: | xbrli:sharesItemType
Balance Type: | na
Period Type: | duration

X
- Definition The amount recorded to additional Paid in Capital account as a result of the conversion of warrants for preferred stock to outstanding common stock. + References No definition available. + Details
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