Share-based Compensation (Tables)

6 Months Ended

Jun. 30, 2016

Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]

Summary of Non-cash, Share-based Compensation Expense

For the three and six month periods ended June 30, 2016 and 2015, the Company recognized the following non-cash, share-based compensation expense in the statements of operations (in thousands):

	Three Months Ended June 30,				Six Months Ended June 30,
	2016		2015		2016		2015
Research and development	$	53	$	47	$	95	$	89
General and administrative		130		128		243		216
Total	$	183	$	175	$	338	$	305

Summary of Stock Option Activities

Stock option transactions for the six month period ended June 30, 2016 under the Company’s stock incentive plans were as follows:

	Number of Options			Weighted Average Exercise Price		Weighted Average Remaining Contractual Term (in years)
Options outstanding at December 31, 2015		161,278		$	18.30		6.97
Granted		442,300			3.31
Exercised	—			—
Forfeited and cancelled		(18,713	)		28.39
Options outstanding at June 30, 2016		584,865		$	6.64		9.27
Options exercisable at June 30, 2016		131,876		$	16.50		7.43
Options vested and expected to vest		583,632		$	6.65		9.27

Summary of RSU Activity

Stock award transactions related to restricted stock units for the six month period ended June 30, 2016 under the Company’s stock incentive plans were as follows:

	Number of Shares			Weighted Average Grant Date Fair Value
Restricted stock units outstanding at December 31, 2015		62,359		$	8.36
Granted		—			—
Vested and released		(15,131	)		7.95
Forfeited and cancelled		(471	)		4.69
Restricted stock units outstanding at June 30, 2016		46,757		$	8.53