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Commitments and Contingencies (Details Textual) $ in Thousands |  | 12 Months Ended |
--- | --- | --- | ---
Mar. 02, 2016 | Dec. 31, 2017 USD ($) | Dec. 31, 2016 USD ($) | Aug. 01, 2013 ft²
Commitments And Contingencies [Line Items] |  |  |  |
Area of office facilities taken on lease | ft² |  |  |  | 5,300
Additional operating lease term | 38 months |  |  |
Lease renewal start date | Oct. 01, 2016 |  |  |
Lease expiration date | Nov. 30, 2019 |  |  |
Rent expense |  | $ 82 | $ 81 |
Royalty buy down due period |  | 6 months |  |
Minimum |  |  |  |
Commitments And Contingencies [Line Items] |  |  |  |
Percentage of royalty obligation |  | 12.50% |  |
Percentage of range of royalties that can be bought down |  | 12.50% |  |
Maximum |  |  |  |
Commitments And Contingencies [Line Items] |  |  |  |
Percentage of royalty obligation |  | 25.00% |  |
Percentage of range of royalties that can be bought down |  | 17.00% |  |
Clinical Research Agreement with Duke University |  |  |  |
Commitments And Contingencies [Line Items] |  |  |  |
Agreement termination notice period |  | 90 days |  |
Upon Food and Drug Administration Approval |  |  |  |
Commitments And Contingencies [Line Items] |  |  |  |
Expected milestone payments due upon approval |  | $ 8,000 |  |
Upon Regulatory Marketing Approval |  |  |  |
Commitments And Contingencies [Line Items] |  |  |  |
Expected milestone payments due upon approval |  | $ 5,000 |  |
CPEC |  |  |  |
Commitments And Contingencies [Line Items] |  |  |  |
Percentage of royalty obligation |  | 5.00% |  |

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