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Share-based Compensation - Summary of Stock Option Activities (Details) - USD ($)
$ / shares in Units, $ in Thousands
12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Number of Stock Options    
Number of Options, Options outstanding, beginning of period 629,629 161,278
Number of Options, Granted 469,600 487,700
Number of Options, Forfeited and cancelled (487,254) (19,349)
Number of Options, Options outstanding, end of period 611,975 629,629
Number of Options, Options exercisable, end of period 348,961  
Number of Options, Options vested and expected to vest 611,101  
Stock Options, Weighted Average Exercise Price    
Weighted Average Exercise Price, Options outstanding, beginning of period $ 6.30 $ 18.30
Weighted Average Exercise Price, Granted 2.54 3.22
Weighted Average Exercise Price, Forfeited and cancelled 3.05 28.70
Weighted Average Exercise Price, Options outstanding, end of period 6.00 $ 6.30
Weighted Average Exercise Price, Options exercisable, end of period 8.27  
Weighted Average Exercise Price, Options vested and expected to vest, end of period $ 6.00  
Stock Options, Weighted Average Remaining Contractual Term    
Weighted Average Remaining Contractual Term (in years), Options outstanding 8 years 1 month 20 days 8 years 10 months 9 days
Weighted Average Remaining Contractual Term (in years), Options exercisable 7 years 7 months 2 days  
Weighted Average Remaining Contractual Term (in years), Options vested and expected to vest 8 years 1 month 20 days  
Share Options, Aggregate Intrinsic Value    
Aggregate intrinsic value, Options Outstanding, end of period   $ 25