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Equity Financings and Warrants (Details Textual) - USD ($) | 1 Months Ended | 12 Months Ended |  |
--- | --- | --- | --- | ---
Feb. 22, 2019 | Dec. 31, 2018 | Dec. 31, 2017 | Jan. 25, 2019 | Jan. 11, 2017
Equity Financing And Warrants [Line Items] |  |  |  |  |
Common stock, par value |  | $ 0.001 | $ 0.001 |  |
Common stock, shares issued |  | 13,924,058 | 11,775,062 |  |
JonesTrading |  |  |  |  |
Equity Financing And Warrants [Line Items] |  |  |  |  |
Percentage of selling commission per additional shares sold |  |  |  |  | 3.00%
Sales Agreement |  |  |  |  |
Equity Financing And Warrants [Line Items] |  |  |  |  |
Aggregate offering price of common stock authorized |  | $ 10,200,000 |  |  |
Common stock, shares issued |  | 2,133,828 | 2,677,525 |  |
Net proceeds from issuance of common stock |  | $ 3,400,000 | $ 6,100,000 |  |
Sales Agreement | JonesTrading |  |  |  |  |
Equity Financing And Warrants [Line Items] |  |  |  |  |
Common stock, par value |  |  |  |  | $ 0.001
Aggregate offering price of common stock authorized |  |  |  |  | $ 7,300,000
Subsequent Event | Sales Agreement |  |  |  |  |
Equity Financing And Warrants [Line Items] |  |  |  |  |
Aggregate offering price of common stock authorized |  |  |  | $ 12,700,000 |
Common stock, shares issued | 4,431,053 |  |  |  |
Net proceeds from issuance of common stock | $ 2,400,000 |  |  |  |
Subsequent Event | Sales Agreement | JonesTrading |  |  |  |  |
Equity Financing And Warrants [Line Items] |  |  |  |  |
Aggregate offering price of common stock authorized |  |  |  | $ 12,700,000 |

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