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STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2018 | Dec. 31, 2017
Costs and expenses: |  |
Research and development | $ 4,239 | $ 14,076
General and administrative | 3,879 | 4,636
Total costs and expenses | 8,118 | 18,712
Loss from operations | (8,118) | (18,712)
Interest and other income | 162 | 167
Interest expense | (8) | (6)
Loss before income taxes | (7,964) | (18,551)
Income tax benefit | 31 | 61
Net loss | (7,933) | (18,490)
Change in unrealized loss on marketable securities | 2 | 17
Comprehensive loss | $ (7,931) | $ (18,473)
Net loss per share: |  |
Basic and diluted | $ (0.57) | $ (1.77)
Weighted average shares outstanding: |  |
Basic and diluted | 13,849,055 | 10,431,391

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