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Equity Financings and Warrants (Details Textual) - USD ($)
1 Months Ended 12 Months Ended
Feb. 22, 2019
Dec. 31, 2018
Dec. 31, 2017
Jan. 25, 2019
Jan. 11, 2017
Equity Financing And Warrants [Line Items]          
Common stock, par value   $ 0.001 $ 0.001    
Common stock, shares issued   13,924,058 11,775,062    
JonesTrading          
Equity Financing And Warrants [Line Items]          
Percentage of selling commission per additional shares sold         3.00%
Sales Agreement          
Equity Financing And Warrants [Line Items]          
Aggregate offering price of common stock authorized   $ 10,200,000      
Common stock, shares issued   2,133,828 2,677,525    
Net proceeds from issuance of common stock   $ 3,400,000 $ 6,100,000    
Sales Agreement | JonesTrading          
Equity Financing And Warrants [Line Items]          
Common stock, par value         $ 0.001
Aggregate offering price of common stock authorized         $ 7,300,000
Subsequent Event | Sales Agreement          
Equity Financing And Warrants [Line Items]          
Aggregate offering price of common stock authorized       $ 12,700,000  
Common stock, shares issued 4,431,053        
Net proceeds from issuance of common stock $ 2,400,000        
Subsequent Event | Sales Agreement | JonesTrading          
Equity Financing And Warrants [Line Items]          
Aggregate offering price of common stock authorized       $ 12,700,000