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Share-based Compensation - Summary of Stock Option Activities (Details) - $ / shares
6 Months Ended 12 Months Ended
Jun. 30, 2019
Dec. 31, 2018
Number of Stock Options    
Number of Options, Options outstanding, beginning of period 33,503  
Number of Options, Forfeited and cancelled (670)  
Number of Options, Options outstanding, end of period 32,833 33,503
Number of Options, Options exercisable, end of period 29,618  
Number of Options, Options vested and expected to vest 32,831  
Stock Options, Weighted Average Exercise Price    
Weighted Average Exercise Price, Options outstanding, beginning of period $ 96.22  
Weighted Average Exercise Price, Forfeited and cancelled 724.80  
Weighted Average Exercise Price, Options outstanding, end of period 83.39 $ 96.22
Weighted Average Exercise Price, Options exercisable, end of period 88.13  
Weighted Average Exercise Price, Options vested and expected to vest, end of period $ 83.39  
Stock Options, Weighted Average Remaining Contractual Term    
Weighted Average Remaining Contractual Term (in years), Options outstanding 6 years 9 months 25 days 7 years 3 months 14 days
Weighted Average Remaining Contractual Term (in years), Options exercisable 6 years 8 months 26 days  
Weighted Average Remaining Contractual Term (in years), Options vested and expected to vest 6 years 9 months 25 days