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Share-based Compensation - Summary of Stock Option Activities (Details) - $ / shares	12 Months Ended
	Dec. 31, 2019	Dec. 31, 2018
Number of Stock Options
Number of Options, Options outstanding, beginning of period	33,503	33,938
Number of Options, Granted		2,220
Number of Options, Forfeited and cancelled	(2,367)	(2,655)
Number of Options, Options outstanding, end of period	31,136	33,503
Number of Options, Options exercisable, end of period	30,074
Number of Options, Options vested and expected to vest	31,136
Stock Options, Weighted Average Exercise Price
Weighted Average Exercise Price, Options outstanding, beginning of period	$ 96.22	$ 107.37
Weighted Average Exercise Price, Granted		12.96
Weighted Average Exercise Price, Forfeited and cancelled	250.36	169.17
Weighted Average Exercise Price, Options outstanding, end of period	84.50	$ 96.22
Weighted Average Exercise Price, Options exercisable, end of period	86.42
Weighted Average Exercise Price, Options vested and expected to vest, end of period	$ 84.50
Stock Options, Weighted Average Remaining Contractual Term
Weighted Average Remaining Contractual Term (in years), Options outstanding	6 years 3 months 3 days	7 years 3 months 14 days
Weighted Average Remaining Contractual Term (in years), Options exercisable	6 years 2 months 26 days
Weighted Average Remaining Contractual Term (in years), Options vested and expected to vest	6 years 3 months 3 days

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The number of shares into which fully or partially vested stock options outstanding as of the balance sheet date can be currently converted under the option plan.

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The weighted-average price as of the balance sheet date at which grantees can acquire the shares reserved for issuance on vested portions of options outstanding and currently exercisable under the stock option plan.

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For presentations that combine terminations, the number of shares under options that were cancelled during the reporting period as a result of occurrence of a terminating event specified in contractual agreements pertaining to the stock option plan or that expired.

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Weighted average price of options that were either forfeited or expired.

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Gross number of share options (or share units) granted during the period.

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Number of options outstanding, including both vested and non-vested options.

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Weighted average price at which grantees can acquire the shares reserved for issuance under the stock option plan.

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Number of fully vested and expected to vest options outstanding that can be converted into shares under option plan. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur.

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Weighted-average exercise price, at which grantee can acquire shares reserved for issuance, for fully vested and expected to vest options outstanding. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur.

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Weighted average per share amount at which grantees can acquire shares of common stock by exercise of options.

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Weighted average remaining contractual term for vested portions of options outstanding and currently exercisable or convertible, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Weighted average remaining contractual term for option awards outstanding, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Weighted average remaining contractual term for fully vested and expected to vest options outstanding, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur.

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