<SEC-DOCUMENT>0001104659-20-006493.txt : 20200124
<SEC-HEADER>0001104659-20-006493.hdr.sgml : 20200124
<ACCEPTANCE-DATETIME>20200124080114
ACCESSION NUMBER:		0001104659-20-006493
CONFORMED SUBMISSION TYPE:	SC 13G/A
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20200124
DATE AS OF CHANGE:		20200124

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ARCA biopharma, Inc.
		CENTRAL INDEX KEY:			0000907654
		STANDARD INDUSTRIAL CLASSIFICATION:	IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES [2835]
		IRS NUMBER:				363855489
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-51477
		FILM NUMBER:		20543692

	BUSINESS ADDRESS:	
		STREET 1:		11080 CIRCLEPOINT ROAD
		STREET 2:		SUITE 140
		CITY:			WESTMINSTER
		STATE:			CO
		ZIP:			80020
		BUSINESS PHONE:		720-940-2200

	MAIL ADDRESS:	
		STREET 1:		11080 CIRCLEPOINT ROAD
		STREET 2:		SUITE 140
		CITY:			WESTMINSTER
		STATE:			CO
		ZIP:			80020

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	NUVELO INC
		DATE OF NAME CHANGE:	20030203

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	HYSEQ INC
		DATE OF NAME CHANGE:	19970610

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Tekla Capital Management LLC
		CENTRAL INDEX KEY:			0001300336
		IRS NUMBER:				010628853
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			0930

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		100 FEDERAL STREET
		STREET 2:		19TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02110
		BUSINESS PHONE:		617 772-8500

	MAIL ADDRESS:	
		STREET 1:		100 FEDERAL STREET
		STREET 2:		19TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02110

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Hambrecht & Quist Capital Management LLC
		DATE OF NAME CHANGE:	20040811
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>tm203765d1_sc13ga.htm
<DESCRIPTION>SC 13G/A
<TEXT>
<HTML>
<HEAD>
     <TITLE></TITLE>
</HEAD>
<BODY STYLE="font: 10pt Times New Roman, Times, Serif">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<!-- Field: Rule-Page --><DIV STYLE="margin-top: 0; margin-bottom: 0; width: 100%"><DIV STYLE="font-size: 1pt; border-top: Black 2pt solid; border-bottom: Black 1pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 23%; padding-right: 0.7pt; padding-bottom: 0.7pt; padding-left: 0.7pt">&nbsp;</TD>
    <TD STYLE="width: 54%; padding-right: 0.7pt; padding-bottom: 0.7pt; padding-left: 0.7pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>UNITED STATES</B></FONT></TD>
    <TD STYLE="width: 23%; padding-right: 0.7pt; padding-bottom: 0.7pt; padding-left: 0.7pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.7pt; padding-bottom: 0.7pt; padding-left: 0.7pt">&nbsp;</TD>
    <TD STYLE="padding-right: 0.7pt; padding-bottom: 0.7pt; padding-left: 0.7pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>SECURITIES AND EXCHANGE COMMISSION</B></FONT></TD>
    <TD STYLE="padding-right: 0.7pt; padding-bottom: 0.7pt; padding-left: 0.7pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.7pt; padding-bottom: 0.7pt; padding-left: 0.7pt">&nbsp;</TD>
    <TD STYLE="padding-right: 0.7pt; padding-bottom: 0.7pt; padding-left: 0.7pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Washington, D.C. 20549</B></FONT></TD>
    <TD STYLE="padding-right: 0.7pt; padding-bottom: 0.7pt; padding-left: 0.7pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.7pt; padding-bottom: 0.7pt; padding-left: 0.7pt">&nbsp;</TD>
    <TD STYLE="padding-right: 0.7pt; padding-bottom: 0.7pt; padding-left: 0.7pt; text-align: center">&nbsp;</TD>
    <TD STYLE="padding-right: 0.7pt; padding-bottom: 0.7pt; padding-left: 0.7pt">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SCHEDULE 13G</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Under the Securities Exchange Act of
1934<BR>
(Amendment No.&nbsp;4)*</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 1pt solid"><B>ARCA
biopharma, Inc.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Name of Issuer)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 1pt solid"><B>Common
Stock</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Title of Class of Securities)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 1pt solid"><B>00211Y407</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(CUSIP Number)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 1pt solid"><B>December
31, 2019</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Date of Event Which Requires Filing of
this Statement)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Check the appropriate box to designate the rule pursuant to
which this Schedule is filed:</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR>
    <TD STYLE="width: 9%; padding: 3pt; text-align: center"><FONT STYLE="font-family: Wingdings; font-size: 10pt"><FONT STYLE="font-family: Wingdings">&#120;</FONT></FONT></TD>
    <TD STYLE="width: 91%; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Rule 13d-1(b)</FONT></TD></TR>
<TR>
    <TD STYLE="padding: 3pt; text-align: center"><FONT STYLE="font-family: Wingdings; font-size: 10pt"><FONT STYLE="font-family: Wingdings">&#168;</FONT></FONT></TD>
    <TD STYLE="padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Rule 13d-1(c)</FONT></TD></TR>
<TR>
    <TD STYLE="padding: 3pt; text-align: center"><FONT STYLE="font-family: Wingdings; font-size: 10pt"><FONT STYLE="font-family: Wingdings">&#168;</FONT></FONT></TD>
    <TD STYLE="padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Rule 13d-1(d)</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">*The remainder of this cover page shall be filled out for a
reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment
containing information which would alter the disclosures provided in a prior cover page.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">The information required in the remainder of this cover page
shall not be deemed to be &quot;filed&quot; for the purpose of Section 18 of the Securities Exchange Act of 1934 (&quot;Act&quot;)
or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however,
see the Notes).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<!-- Field: Page; Sequence: 1 -->
    <DIV STYLE="margin-top: 12pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR>
    <TD COLSPAN="6" STYLE="border-bottom: Black 1pt solid; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">CUSIP No.&nbsp;</FONT></TD></TR>
<TR>
    <TD COLSPAN="6" STYLE="padding: 3pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">1.</FONT></TD>
    <TD COLSPAN="4" STYLE="border-bottom: Black 1pt solid; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Names of Reporting Persons</FONT><FONT STYLE="font-size: 10pt"><BR>
Tekla Capital Management LLC</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="6" STYLE="padding: 3pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">2. </FONT></TD>
    <TD COLSPAN="4" STYLE="padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Check the Appropriate Box if a Member of a Group (See Instructions)</FONT></TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(a)</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; padding: 3pt"><FONT STYLE="font-family: Wingdings; font-size: 10pt">o</FONT></TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(b)</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; padding: 3pt"><FONT STYLE="font-family: Wingdings; font-size: 10pt">o</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="6" STYLE="padding: 3pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">3.</FONT></TD>
    <TD COLSPAN="4" STYLE="vertical-align: bottom; border-bottom: Black 1pt solid; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">SEC Use Only </FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="6" STYLE="padding: 3pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">4.</FONT></TD>
    <TD COLSPAN="4" STYLE="vertical-align: bottom; border-bottom: Black 1pt solid; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Citizenship or Place of Organization </FONT><FONT STYLE="font-size: 10pt"><BR>
Delaware</FONT></TD></TR>
<TR>
    <TD COLSPAN="3" STYLE="padding: 3pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 3pt; text-align: right">&nbsp;</TD>
    <TD STYLE="padding: 3pt">&nbsp;</TD></TR>
<TR>
    <TD COLSPAN="3" ROWSPAN="7" STYLE="padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Number of<BR>
Shares<BR>
Beneficially<BR>
Owned by<BR>
Each<BR>
Reporting<BR>
Person With</FONT></TD>
    <TD COLSPAN="2" STYLE="vertical-align: top; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">5.</FONT></TD>
    <TD STYLE="vertical-align: bottom; border-bottom: Black 1pt solid; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Sole Voting Power </FONT><FONT STYLE="font-size: 10pt"><BR>
0</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="3" STYLE="padding: 3pt">&nbsp;</TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="vertical-align: top; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">6.</FONT></TD>
    <TD STYLE="vertical-align: bottom; border-bottom: Black 1pt solid; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Shared Voting Power</FONT> <FONT STYLE="font-size: 10pt"><BR>
36,068</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="3" STYLE="padding: 3pt">&nbsp;</TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="vertical-align: top; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">7.</FONT></TD>
    <TD STYLE="vertical-align: bottom; border-bottom: Black 1pt solid; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Sole Dispositive Power</FONT> <FONT STYLE="font-size: 10pt"><BR>
36,068</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="3" STYLE="padding: 3pt">&nbsp;</TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="vertical-align: top; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">8.</FONT></TD>
    <TD STYLE="vertical-align: bottom; border-bottom: Black 1pt solid; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Shared Dispositive Power <BR>
0</FONT></TD></TR>
<TR>
    <TD COLSPAN="6" STYLE="padding: 3pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">9.</FONT></TD>
    <TD COLSPAN="4" STYLE="vertical-align: bottom; border-bottom: Black 1pt solid; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Aggregate Amount Beneficially Owned by Each Reporting Person</FONT><FONT STYLE="font-size: 10pt"><BR>
36,068</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="6" STYLE="padding: 3pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">10.</FONT></TD>
    <TD COLSPAN="4" STYLE="vertical-align: bottom; border-bottom: Black 1pt solid; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)&nbsp;&nbsp;</FONT><FONT STYLE="font-family: Wingdings; font-size: 10pt">o</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="6" STYLE="padding: 3pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">11.</FONT></TD>
    <TD COLSPAN="4" STYLE="vertical-align: bottom; border-bottom: Black 1pt solid; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Percent of Class Represented by Amount in Row (9)</FONT><FONT STYLE="font-size: 10pt"><BR>
2.3%</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="6" STYLE="padding: 3pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">12.</FONT></TD>
    <TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: Black 1pt solid; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Type of Reporting Person (See Instructions)</FONT><FONT STYLE="font-size: 10pt"><BR>
IN</FONT></TD></TR>
<TR>
    <TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 4%">&nbsp;</TD>
    <TD STYLE="width: 6%">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 5%">&nbsp;</TD>
    <TD STYLE="width: 82%">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR>
    <TD COLSPAN="6" STYLE="border-bottom: Black 1pt solid; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">CUSIP No.&nbsp;</FONT></TD></TR>
<TR>
    <TD COLSPAN="6" STYLE="padding: 3pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">1.</FONT></TD>
    <TD COLSPAN="4" STYLE="border-bottom: Black 1pt solid; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Names of Reporting Persons</FONT><FONT STYLE="font-size: 10pt"><BR>
Daniel R. Omstead</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="6" STYLE="padding: 3pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">2. </FONT></TD>
    <TD COLSPAN="4" STYLE="padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Check the Appropriate Box if a Member of a Group (See Instructions)</FONT></TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(a)</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; padding: 3pt"><FONT STYLE="font-family: Wingdings; font-size: 10pt">o</FONT></TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(b)</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; padding: 3pt"><FONT STYLE="font-family: Wingdings; font-size: 10pt">o</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="6" STYLE="padding: 3pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">3.</FONT></TD>
    <TD COLSPAN="4" STYLE="vertical-align: bottom; border-bottom: Black 1pt solid; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">SEC Use Only </FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="6" STYLE="padding: 3pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">4.</FONT></TD>
    <TD COLSPAN="4" STYLE="vertical-align: bottom; border-bottom: Black 1pt solid; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Citizenship or Place of Organization </FONT><FONT STYLE="font-size: 10pt"><BR>
Delaware</FONT></TD></TR>
<TR>
    <TD COLSPAN="3" STYLE="padding: 3pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 3pt; text-align: right">&nbsp;</TD>
    <TD STYLE="padding: 3pt">&nbsp;</TD></TR>
<TR>
    <TD COLSPAN="3" ROWSPAN="7" STYLE="padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Number of<BR>
Shares<BR>
Beneficially<BR>
Owned by<BR>
Each<BR>
Reporting<BR>
Person With</FONT></TD>
    <TD COLSPAN="2" STYLE="vertical-align: top; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">5.</FONT></TD>
    <TD STYLE="vertical-align: bottom; border-bottom: Black 1pt solid; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Sole Voting Power </FONT><FONT STYLE="font-size: 10pt"><BR>
0</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="3" STYLE="padding: 3pt">&nbsp;</TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="vertical-align: top; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">6.</FONT></TD>
    <TD STYLE="vertical-align: bottom; border-bottom: Black 1pt solid; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Shared Voting Power</FONT> <FONT STYLE="font-size: 10pt"><BR>
36,068</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="3" STYLE="padding: 3pt">&nbsp;</TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="vertical-align: top; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">7.</FONT></TD>
    <TD STYLE="vertical-align: bottom; border-bottom: Black 1pt solid; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Sole Dispositive Power</FONT> <FONT STYLE="font-size: 10pt"><BR>
36,068</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="3" STYLE="padding: 3pt">&nbsp;</TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="vertical-align: top; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">8.</FONT></TD>
    <TD STYLE="vertical-align: bottom; border-bottom: Black 1pt solid; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Shared Dispositive Power <BR>
0</FONT></TD></TR>
<TR>
    <TD COLSPAN="6" STYLE="padding: 3pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">9.</FONT></TD>
    <TD COLSPAN="4" STYLE="vertical-align: bottom; border-bottom: Black 1pt solid; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Aggregate Amount Beneficially Owned by Each Reporting Person</FONT><FONT STYLE="font-size: 10pt"><BR>
36,068</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="6" STYLE="padding: 3pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">10.</FONT></TD>
    <TD COLSPAN="4" STYLE="vertical-align: bottom; border-bottom: Black 1pt solid; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)&nbsp;&nbsp;</FONT><FONT STYLE="font-family: Wingdings; font-size: 10pt">o</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="6" STYLE="padding: 3pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">11.</FONT></TD>
    <TD COLSPAN="4" STYLE="vertical-align: bottom; border-bottom: Black 1pt solid; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Percent of Class Represented by Amount in Row (9)</FONT><FONT STYLE="font-size: 10pt"><BR>
2.3%</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="6" STYLE="padding: 3pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">12.</FONT></TD>
    <TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: Black 1pt solid; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Type of Reporting Person (See Instructions)</FONT><FONT STYLE="font-size: 10pt"><BR>
IN</FONT></TD></TR>
<TR>
    <TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 4%">&nbsp;</TD>
    <TD STYLE="width: 6%">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 5%">&nbsp;</TD>
    <TD STYLE="width: 82%">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR>
    <TD COLSPAN="4" STYLE="padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Item 1.</B></FONT></TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(a)</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Name of Issuer<BR>
ARCA biopharma, Inc.</FONT></TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(b)</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Address of Issuer&rsquo;s Principal Executive Offices<BR>
11080 CirclePoint Rd, Suite 140, Westminster, CO 80020</FONT></TD></TR>
<TR>
    <TD COLSPAN="4" STYLE="padding: 3pt">&nbsp;</TD></TR>
<TR>
    <TD COLSPAN="4" STYLE="padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Item 2.</B></FONT></TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(a)</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Name of Person Filing<BR>
</FONT><FONT STYLE="font-size: 10pt">Tekla Capital Management LLC</FONT></TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(b)</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Address of Principal Business Office or, if none, Residence<BR>
100 Federal Street, 19</FONT><FONT STYLE="font-size: 10pt">th&nbsp;Floor, Boston, MA 02110</FONT></TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(c)</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Citizenship<BR>
Delaware Corporation</FONT></TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(d)</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Title of Class of Securities<BR>
Common Stock</FONT></TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(e)</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">CUSIP Number<BR>
00211Y407</FONT></TD></TR>
<TR>
    <TD COLSPAN="4" STYLE="padding: 3pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Item 3.</B></FONT></TD>
    <TD COLSPAN="3" STYLE="padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>If this statement is filed pursuant to &sect;&sect;240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:</B></FONT></TD></TR>
<TR>
    <TD STYLE="width: 8%; padding-top: 3pt; padding-bottom: 3pt">&nbsp;</TD>
    <TD STYLE="width: 4%; padding-top: 3pt; padding-bottom: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(a)</FONT></TD>
    <TD STYLE="width: 4%; padding-top: 3pt; padding-bottom: 3pt; padding-left: 22pt; text-indent: -22pt"><FONT STYLE="font-family: Wingdings; font-size: 10pt"><FONT STYLE="font-family: Wingdings">&#168;</FONT></FONT></TD>
    <TD STYLE="width: 84%; padding-top: 3pt; padding-bottom: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);</FONT></TD></TR>
<TR>
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt">&nbsp;</TD>
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(b)</FONT></TD>
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt; padding-left: 22pt; text-indent: -22pt"><FONT STYLE="font-family: Wingdings; font-size: 10pt"><FONT STYLE="font-family: Wingdings">&#168;</FONT></FONT></TD>
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);</FONT></TD></TR>
<TR>
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt">&nbsp;</TD>
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(c)</FONT></TD>
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt; padding-left: 22pt; text-indent: -22pt"><FONT STYLE="font-family: Wingdings; font-size: 10pt"><FONT STYLE="font-family: Wingdings">&#168;</FONT></FONT></TD>
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);</FONT></TD></TR>
<TR>
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 3pt; padding-bottom: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(d)</FONT></TD>
    <TD STYLE="vertical-align: top; padding-top: 3pt; padding-bottom: 3pt; padding-left: 22pt; text-indent: -22pt"><FONT STYLE="font-family: Wingdings; font-size: 10pt"><FONT STYLE="font-family: Wingdings">&#168;</FONT></FONT></TD>
    <TD STYLE="vertical-align: top; padding-top: 3pt; padding-bottom: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);</FONT></TD></TR>
<TR>
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 3pt; padding-bottom: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(e)</FONT></TD>
    <TD STYLE="vertical-align: top; padding-top: 3pt; padding-bottom: 3pt; padding-left: 22pt; text-indent: -22pt"><FONT STYLE="font-family: Wingdings; font-size: 10pt"><FONT STYLE="font-family: Wingdings">&#120;</FONT></FONT></TD>
    <TD STYLE="vertical-align: top; padding-top: 3pt; padding-bottom: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">An investment adviser in accordance with &sect;240.13d-1(b)(1)(ii)(E);</FONT></TD></TR>
<TR>
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 3pt; padding-bottom: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(f)</FONT></TD>
    <TD STYLE="vertical-align: top; padding-top: 3pt; padding-bottom: 3pt; padding-left: 22pt; text-indent: -22pt"><FONT STYLE="font-family: Wingdings">&#168;</FONT></TD>
    <TD STYLE="vertical-align: top; padding-top: 3pt; padding-bottom: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">An employee benefit plan or endowment fund in accordance with &sect;240.13d-1(b)(1)(ii)(F);</FONT></TD></TR>
<TR>
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 3pt; padding-bottom: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(g)</FONT></TD>
    <TD STYLE="vertical-align: top; padding-top: 3pt; padding-bottom: 3pt; padding-left: 22pt; text-indent: -22pt"><FONT STYLE="font-family: Wingdings; font-size: 10pt"><FONT STYLE="font-family: Wingdings">&#168;</FONT></FONT></TD>
    <TD STYLE="vertical-align: top; padding-top: 3pt; padding-bottom: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">A parent holding company or control person in accordance with &sect;240.13d-1(b)(1)(ii)(G);</FONT></TD></TR>
<TR>
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 3pt; padding-bottom: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(h)</FONT></TD>
    <TD STYLE="vertical-align: top; padding-top: 3pt; padding-bottom: 3pt; padding-left: 22pt; text-indent: -22pt"><FONT STYLE="font-family: Wingdings; font-size: 10pt"><FONT STYLE="font-family: Wingdings">&#168;</FONT></FONT></TD>
    <TD STYLE="vertical-align: top; padding-top: 3pt; padding-bottom: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">A savings association as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);</FONT></TD></TR>
<TR>
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 3pt; padding-bottom: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(i)</FONT></TD>
    <TD STYLE="vertical-align: top; padding-top: 3pt; padding-bottom: 3pt; padding-left: 22pt; text-indent: -22pt"><FONT STYLE="font-family: Wingdings; font-size: 10pt"><FONT STYLE="font-family: Wingdings">&#168;</FONT></FONT></TD>
    <TD STYLE="vertical-align: top; padding-top: 3pt; padding-bottom: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);</FONT></TD></TR>
<TR>
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt">&nbsp;</TD>
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(j)</FONT></TD>
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt; padding-left: 22pt; text-indent: -22pt"><FONT STYLE="font-family: Wingdings; font-size: 10pt"><FONT STYLE="font-family: Wingdings">&#168;</FONT></FONT></TD>
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">A non-U.S. institution in accordance with &sect; 240.13d&ndash;1(b)(1)(ii)(J);</FONT></TD></TR>
<TR>
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt">&nbsp;</TD>
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(k)</FONT></TD>
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt; padding-left: 22pt; text-indent: -22pt"><FONT STYLE="font-family: Wingdings; font-size: 10pt"><FONT STYLE="font-family: Wingdings">&#168;</FONT></FONT></TD>
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Group, in accordance with &sect; 240.13d&ndash;1(b)(1)(ii)(K). If filing as a non-U.S. institution in accordance with &sect;&nbsp;240.13d&ndash;1(b)(1)(ii)(J), please specify the type of institution:____________________________</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>







<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR>
    <TD STYLE="padding: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>Item 4.</B></FONT></TD>
    <TD COLSPAN="3" STYLE="padding: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>Ownership</B></FONT></TD></TR>
<TR>
    <TD COLSPAN="4" STYLE="padding: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1. </FONT></TD></TR>
<TR>
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 3pt; padding-bottom: 3pt; text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(a)</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; padding: 3pt">Amount beneficially owned:<BR>
  36,068</TD></TR>
<TR>
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 3pt; padding-bottom: 3pt; text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(b)</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; padding: 3pt">Percent of class:<BR>
  2.3% </TD></TR>
<TR>
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 3pt; padding-bottom: 3pt; text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(c)</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1pt solid; padding: 3pt">Number of shares as to which the person has: &nbsp;</TD></TR>
<TR>
    <TD STYLE="width: 9%; padding-top: 3pt; padding-bottom: 3pt">&nbsp;</TD>
    <TD STYLE="width: 4%; padding-top: 3pt; padding-bottom: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 5%; padding-top: 3pt; padding-bottom: 3pt; text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(i)</FONT></TD>
    <TD STYLE="width: 82%; border-bottom: Black 1pt solid; padding: 3pt">Sole power to vote or to direct the vote<BR>
  0 &nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt">&nbsp;</TD>
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 3pt; padding-bottom: 3pt; text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(ii)</FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid; padding: 3pt">Shared power to vote or to direct the vote<BR>
  36,068 </TD></TR>
<TR>
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt">&nbsp;</TD>
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 3pt; padding-bottom: 3pt; text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(iii)</FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid; padding: 3pt">Sole power to dispose or to direct the disposition of<BR>
  36,068</TD></TR>
<TR>
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt">&nbsp;</TD>
    <TD STYLE="padding-top: 3pt; padding-bottom: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 3pt; padding-bottom: 3pt; text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(iv)</FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid; padding: 3pt">Shared power to dispose or to direct the disposition of<BR>
  0 &nbsp;</TD></TR>
<TR>
    <TD COLSPAN="4" STYLE="padding: 3pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>Item 5.</B></FONT></TD>
    <TD COLSPAN="3" STYLE="padding: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>Ownership of Five Percent or Less of a Class</B></FONT></TD></TR>
<TR>
    <TD COLSPAN="4" STYLE="padding: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following&nbsp;&nbsp;&nbsp;</FONT><FONT STYLE="font: 10pt Wingdings"><FONT STYLE="font-family: Wingdings">&#120;</FONT></FONT><FONT STYLE="font-size: 10pt">.</FONT></TD></TR>
<TR>
    <TD COLSPAN="4" STYLE="padding: 3pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>Item 6.</B></FONT></TD>
    <TD COLSPAN="3" STYLE="padding: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>Ownership of More than Five Percent on Behalf of Another Person</B></FONT></TD></TR>
<TR>
    <TD COLSPAN="4" STYLE="padding: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">One person has the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the Common Stock of ARCA biopharma, Inc.&nbsp;&nbsp;The interest of Tekla Life Sciences Investors, an investment company registered under the Investment Company Act of 1940, in the Common Stock of ARCA biopharma, Inc. amounted to 36,068 shares or 2.3% of the total outstanding Common Stock at December 31, 2019.&nbsp;&nbsp;</FONT></TD></TR>
<TR>
    <TD COLSPAN="4" STYLE="padding: 3pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; padding: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>Item 7.</B></FONT></TD>
    <TD COLSPAN="3" STYLE="padding: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person</B></FONT></TD></TR>
<TR>
    <TD COLSPAN="4" STYLE="padding: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">See attached Exhibit A.</FONT></TD></TR>
<TR>
    <TD COLSPAN="4" STYLE="padding: 3pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>Item 8.</B></FONT></TD>
    <TD COLSPAN="3" STYLE="padding: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>Identification and Classification of Members of the Group</B></FONT></TD></TR>
<TR>
    <TD COLSPAN="4" STYLE="padding: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Not applicable.&nbsp;&nbsp;</FONT></TD></TR>
<TR>
    <TD COLSPAN="4" STYLE="padding: 3pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>Item 9.</B></FONT></TD>
    <TD COLSPAN="3" STYLE="padding: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>Notice of Dissolution of Group</B></FONT></TD></TR>
<TR>
    <TD COLSPAN="4" STYLE="padding: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">N/A</FONT></TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

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<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR>
    <TD STYLE="width: 9%; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Item 10.</B></FONT></TD>
    <TD STYLE="width: 91%; padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Certification</B></FONT></TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="padding: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Signature</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">After reasonable inquiry and to the best of my knowledge and
belief, I certify that the information set forth in this statement is true, complete and correct.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<TR>
    <TD STYLE="vertical-align: top; width: 50%">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; width: 50%; border-bottom: Black 1pt solid; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">January
    24, 2020</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Date</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: Black 1pt solid; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><BR>
/s/ Laura Woodward</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Signature</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: Black 1pt solid; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><BR>
Laura Woodward, Treasurer</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Name/Title</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Exhibit&nbsp;A</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-family: Times New Roman, Times, Serif">Tekla
Capital Management LLC (&ldquo;TCM&rdquo;), an investment adviser registered pursuant to Section 203 of the Investment Advisers
Act of 1940, is the beneficial owner of 36,068 shares (or 2.3%) of the Common Stock of ARCA biopharma, Inc. (the &ldquo;Company&rdquo;)
as a result of acting as investment adviser to </FONT>Tekla Life Sciences Investors (&ldquo;HQL&rdquo;), which is registered as
an investment company pursuant to Section 8 of the Investment Company Act of 1940. Each of TCM and Daniel R. Omstead, through his
control of TCM, has sole power to dispose of the 36,068 shares beneficially owned by HQL. Neither TCM nor Daniel R. Omstead has
the sole power to vote or direct the vote of the shares beneficially owned by HQL, which power resides in the fund&rsquo;s Board
of Trustees. TCM carries out the voting of the shares under written guidelines established by the fund&rsquo;s Board of Trustees.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<DOCUMENT>
<TYPE>EX-99.1
<SEQUENCE>2
<FILENAME>tm203765d1_ex99-1.htm
<DESCRIPTION>EXHIBIT 99.1
<TEXT>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B>Exhibit&nbsp;99.1</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Joint Filing Agreement</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">The undersigned persons, on January 24, 2020, agree and
consent to the joint filing on their behalf of this Schedule 13G in connection with their beneficial ownership of the Common Stock
of ARCA biopharma,&nbsp;Inc. on December&nbsp;31, 2019.</P>

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<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Tekla Capital Management LLC</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 3%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">By</FONT></TD>
    <TD STYLE="width: 43%; border-bottom: Black 1pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/ Laura Woodward</FONT></TD>
    <TD STYLE="width: 4%">&nbsp;</TD>
    <TD STYLE="width: 50%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Laura Woodward</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Daniel R. Omstead</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">By</FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/ Daniel R. Omstead</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Daniel R. Omstead</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
</TABLE>


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