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Share-based Compensation - Estimated Weighted Average Grant Date Fair Value Per Share (Details) - $ / shares
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Estimated weighted average grant date fair value per share    
Expected term 5 years 10 months 24 days 6 years
Expected volatility 94.00% 96.00%
Risk-free interest rate 1.08% 0.50%
Expected dividend yield 0.00% 0.00%
Weighted-average grant date fair value per share $ 2.09 $ 3.28