<SEC-DOCUMENT>0001104659-24-119331.txt : 20241114
<SEC-HEADER>0001104659-24-119331.hdr.sgml : 20241114
<ACCEPTANCE-DATETIME>20241114174956
ACCESSION NUMBER:		0001104659-24-119331
CONFORMED SUBMISSION TYPE:	SC 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20241114
DATE AS OF CHANGE:		20241114
GROUP MEMBERS:		BONG KOH
GROUP MEMBERS:		NIMISH SHAH
GROUP MEMBERS:		VENROCK HEALTHCARE CAPITAL PARTNERS EG, L.P.
GROUP MEMBERS:		VHCP CO-INVESTMENT HOLDINGS III, LLC
GROUP MEMBERS:		VHCP MANAGEMENT EG, LLC
GROUP MEMBERS:		VHCP MANAGEMENT III, LLC

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Oruka Therapeutics, Inc.
		CENTRAL INDEX KEY:			0000907654
		STANDARD INDUSTRIAL CLASSIFICATION:	IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES [2835]
		ORGANIZATION NAME:           	03 Life Sciences
		IRS NUMBER:				363855489
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-51477
		FILM NUMBER:		241464784

	BUSINESS ADDRESS:	
		STREET 1:		855 OAK GROVE AVE.
		STREET 2:		SUITE 100
		CITY:			MENLO PARK
		STATE:			CA
		ZIP:			94025
		BUSINESS PHONE:		650-606-7910

	MAIL ADDRESS:	
		STREET 1:		855 OAK GROVE AVE.
		STREET 2:		SUITE 100
		CITY:			MENLO PARK
		STATE:			CA
		ZIP:			94025

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ARCA biopharma, Inc.
		DATE OF NAME CHANGE:	20090128

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	NUVELO INC
		DATE OF NAME CHANGE:	20030203

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	HYSEQ INC
		DATE OF NAME CHANGE:	19970610

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Venrock Healthcare Capital Partners III, L.P.
		CENTRAL INDEX KEY:			0001738048
		ORGANIZATION NAME:           	
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		530 FIFTH AVENUE, 22ND FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10036
		BUSINESS PHONE:		212-444-4100

	MAIL ADDRESS:	
		STREET 1:		530 FIFTH AVENUE, 22ND FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10036
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>tm2428137d13_sc13ga.htm
<DESCRIPTION>SC 13G/A
<TEXT>
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<P STYLE="margin: 0">&nbsp;</P>

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<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>UNITED STATES&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SECURITIES AND EXCHANGE COMMISSION&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Washington, D.C. 20549</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SCHEDULE 13G/A</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Under the Securities Exchange Act of 1934&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(Amendment No.&nbsp;1)*</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Oruka Therapeutics,&nbsp;Inc.&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-top: Black 0.5pt solid">(Name of Issuer)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Common stock, $0.001 par value per share&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-top: Black 0.5pt solid">(Title of Class&nbsp;of
Securities)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>687604108&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-top: Black 0.5pt solid">(CUSIP Number)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>September&nbsp;30, 2024&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-top: Black 0.5pt solid">(Date of Event
Which Requires Filing of this Statement)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Check the appropriate box to designate the rule&nbsp;pursuant to which
this Schedule is filed:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
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    <TD STYLE="width: 6%; padding-right: 5.4pt; padding-left: 5.4pt"><P STYLE="font: 10pt Wingdings; margin: 0pt 0; text-align: center; color: #0070c0"><FONT STYLE="font-family: Wingdings; color: Black">&#168;</FONT></P>
    <P STYLE="font: 10pt Wingdings; margin: 0pt 0; text-align: center; color: #0070c0"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="font-family: Wingdings">&#120;</FONT></P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
    <P STYLE="font: 10pt Wingdings; margin: 0pt 0; text-align: center; color: #0070c0"><FONT STYLE="font-family: Wingdings; color: Black">&#168;</FONT></P></TD>
    <TD STYLE="width: 94%; padding-right: 5.4pt; padding-left: 5.4pt"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Rule&nbsp;13d-1(b)</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Rule&nbsp;13d-1(c)</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Rule&nbsp;13d-1(d)</P></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="text-align: justify; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">*The remainder of this cover page&nbsp;shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information
which would alter the disclosures provided in a prior cover page.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="text-align: justify; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">The information required in the remainder of this cover page&nbsp;shall
not be deemed to be &quot;filed&quot; for the purpose of Section&nbsp;18 of the Securities Exchange Act of 1934 (&quot;Act&quot;) or
otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see
the Notes).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif">CUSIP No.&nbsp;687604108&nbsp;</TD>
    <TD STYLE="text-align: right; font: bold 10pt Times New Roman, Times, Serif">Page&nbsp;2 of 14</TD></TR>
  </TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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    <TD STYLE="border: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; width: 5%; text-align: right">1.</TD>
    <TD STYLE="border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; width: 95%; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Names of Reporting Persons</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Venrock Healthcare Capital Partners III, L.P.</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">2.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Check the Appropriate Box if a Member of a Group (See Instructions)</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">(a) <FONT STYLE="font-family: Wingdings">&#120;</FONT> (1)&nbsp;&nbsp;&nbsp;&nbsp;
    (b) <FONT STYLE="font-family: Wingdings">&#168;</FONT><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">3.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt"><P STYLE="margin-top: 0; margin-bottom: 0">SEC
                                            Use Only</P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">4.</TD>
    <TD STYLE="border-right: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Citizenship or Place of Organization</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Delaware</P></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
  <TR>
    <TD ROWSPAN="4" STYLE="border: Black 1pt solid; padding: 2.15pt 5.4pt; width: 13%"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Number of</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Shares</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Beneficially</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Owned by</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Each</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Reporting</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Person With</P></TD>
    <TD STYLE="border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; vertical-align: top; width: 5%; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">5.</TD>
    <TD STYLE="border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; vertical-align: top; width: 82%; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Sole Voting Power</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">0</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">6.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Shared Voting Power</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">3,541,941 (2)</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">7.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Sole Dispositive Power</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">0</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">8.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Shared Dispositive Power</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">3,541,941 (2)</P></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; width: 5%; text-align: right">9.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt; width: 95%"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Aggregate Amount Beneficially Owned by Each Reporting Person</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">3,541,941 (2)</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">10.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt"><P STYLE="margin-top: 0; margin-bottom: 0">Check
                                            if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)&nbsp;&nbsp;&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">&#168;</FONT></P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">11.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Percent of Class Represented by Amount in Row (9)</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">9.99% (3)</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">12.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Type of Reporting Person (See Instructions)</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">PN</P></TD></TR>
  </TABLE>
<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

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<TD STYLE="width: 0%"></TD><TD STYLE="width: 3%">(1)</TD><TD STYLE="text-align: justify; width: 97%">Venrock Healthcare Capital Partners
                                            III, L.P., VHCP Co-Investment Holdings III, LLC, Venrock Healthcare Capital Partners EG,
                                            L.P., VHCP Management III, LLC, VHCP Management EG, LLC, Nimish Shah and Bong Koh are members
                                            of a group for the purposes of this Schedule 13G/A.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<TD STYLE="width: 0%"></TD><TD STYLE="width: 3%">(2)</TD><TD STYLE="text-align: justify; width: 97%">Consists of (i)&nbsp;668,656 shares
                                            and 79,502 shares issuable upon the exercise of immediately exercisable warrants (&ldquo;<B><I>Warrants</I></B>&rdquo;)
                                            held by Venrock Healthcare Capital Partners III, L.P.; (ii)&nbsp;66,890 shares and 9,742
                                            shares issuable upon the exercise of Warrants held by VHCP Co-Investment Holdings III, LLC;
                                            and (iii)&nbsp;2,350,074 shares and 367,077 shares issuable upon the exercise of Warrants
                                            held by Venrock Healthcare Capital Partners EG, L.P. The share numbers in the preceding sentence
                                            represent the maximum number of shares of common stock issuable upon exercise of the Warrants
                                            held by the Reporting Persons as a result of the beneficial ownership provision described
                                            in the following sentence. Under the terms of the Warrants, the Issuer may not effect the
                                            exercise of any such Warrant, and a holder will not be entitled to exercise any portion of
                                            such Warrant, if, upon giving effect to such exercise, the aggregate number of shares of
                                            common stock beneficially owned by the holder (together with its affiliates and other attribution
                                            parties) would exceed 9.99% of the number of shares of common stock outstanding immediately
                                            after giving effect to the exercise.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<TD STYLE="width: 0%"></TD><TD STYLE="width: 3%">(3)</TD><TD STYLE="text-align: justify; width: 97%">This percentage is calculated based
                                            upon the sum of (i)&nbsp;34,998,550 shares of the Issuer&rsquo;s Common Stock outstanding
                                            as of September&nbsp;13, 2024, as reported in the Issuer&rsquo;s Current Report on Form&nbsp;8-K
                                            filed with the Securities and Exchange Commission (the &ldquo;<B><I>SEC</I></B>&rdquo;) on
                                            September&nbsp;13, 2024; and (ii)&nbsp;456,321 shares issuable upon the exercise of the Warrants
                                            described in Footnote 2 above.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif">CUSIP No.&nbsp;687604108&nbsp;</TD>
    <TD STYLE="text-align: right; font: bold 10pt Times New Roman, Times, Serif">Page&nbsp;3 of 14</TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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  <TR STYLE="vertical-align: top">
    <TD STYLE="border: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; width: 5%; text-align: right">1.</TD>
    <TD STYLE="border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt; width: 95%"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Names of Reporting Persons</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">VHCP Co-Investment Holdings III, LLC</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">2.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Check the Appropriate Box if a Member of a Group (See Instructions)</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">(a) <FONT STYLE="font-family: Wingdings">&#120;</FONT> (1)&nbsp;&nbsp;&nbsp;&nbsp;
    (b) <FONT STYLE="font-family: Wingdings">&#168;</FONT><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">3.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt"><P STYLE="margin-top: 0; margin-bottom: 0">SEC
                                            Use Only</P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">4.</TD>
    <TD STYLE="border-right: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Citizenship or Place of Organization</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Delaware</P></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
  <TR>
    <TD ROWSPAN="4" STYLE="border: Black 1pt solid; padding: 2.15pt 5.4pt; width: 13%"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Number of</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Shares</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Beneficially</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Owned by</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Each</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Reporting</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Person With</P></TD>
    <TD STYLE="border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; vertical-align: top; width: 5%; text-align: right">5.</TD>
    <TD STYLE="border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt; vertical-align: top; width: 82%"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Sole Voting Power</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">0</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">6.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Shared Voting Power</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">3,541,941 (2)</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">7.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Sole Dispositive Power</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">0</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">8.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Shared Dispositive Power</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">3,541,941 (2)</P></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; width: 5%; text-align: right">9.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt; width: 95%"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Aggregate Amount Beneficially Owned by Each Reporting Person</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">3,541,941 (2)</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">10.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt"><P STYLE="margin-top: 0; margin-bottom: 0">Check
                                            if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)&nbsp;&nbsp;&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">&#168;</FONT></P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">11.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Percent of Class Represented by Amount in Row (9)</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">9.99% (3)</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">12.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Type of Reporting Person (See Instructions)</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">OO</P></TD></TR>
  </TABLE>
<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0%"></TD><TD STYLE="width: 3%">(1)</TD><TD STYLE="text-align: justify; width: 97%">Venrock Healthcare Capital Partners
                                            III, L.P., VHCP Co-Investment Holdings III, LLC, Venrock Healthcare Capital Partners EG,
                                            L.P., VHCP Management III, LLC, VHCP Management EG, LLC, Nimish Shah and Bong Koh are members
                                            of a group for the purposes of this Schedule 13G/A.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0%"></TD><TD STYLE="width: 3%">(2)</TD><TD STYLE="text-align: justify; width: 97%">Consists of (i)&nbsp;668,656 shares
                                            and 79,502 shares issuable upon the exercise of Warrants held by Venrock Healthcare Capital
                                            Partners III, L.P.; (ii)&nbsp;66,890 shares and 9,742 shares issuable upon the exercise of
                                            Warrants held by VHCP Co-Investment Holdings III, LLC; and (iii)&nbsp;2,350,074 shares and
                                            367,077 shares issuable upon the exercise of Warrants held by Venrock Healthcare Capital
                                            Partners EG, L.P. The share numbers in the preceding sentence represent the maximum number
                                            of shares of common stock issuable upon exercise of the Warrants held by the Reporting Persons
                                            as a result of the beneficial ownership provision described in the following sentence. Under
                                            the terms of the Warrants, the Issuer may not effect the exercise of any such Warrant, and
                                            a holder will not be entitled to exercise any portion of such Warrant, if, upon giving effect
                                            to such exercise, the aggregate number of shares of common stock beneficially owned by the
                                            holder (together with its affiliates and other attribution parties) would exceed 9.99% of
                                            the number of shares of common stock outstanding immediately after giving effect to the exercise.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0%"></TD><TD STYLE="width: 3%">(3)</TD><TD STYLE="text-align: justify; width: 97%">This percentage is calculated based
                                            upon the sum of (i)&nbsp;34,998,550 shares of the Issuer&rsquo;s Common Stock outstanding
                                            as of September&nbsp;13, 2024, as reported in the Issuer&rsquo;s Current Report on Form&nbsp;8-K
                                            filed with the SEC on September&nbsp;13, 2024; and (ii)&nbsp;456,321 shares issuable upon
                                            the exercise of the Warrants described in Footnote 2 above.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%">
  <TR STYLE="vertical-align: bottom">
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif">CUSIP No.&nbsp;687604108&nbsp;</TD>
    <TD STYLE="text-align: right; font: bold 10pt Times New Roman, Times, Serif">Page&nbsp;4 of 14</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD STYLE="border: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; width: 5%; text-align: right">1.</TD>
    <TD STYLE="border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt; width: 95%"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Names of Reporting Persons</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Venrock Healthcare Capital Partners EG, L.P.</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">2.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Check the Appropriate Box if a Member of a Group (See Instructions)</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">(a) <FONT STYLE="font-family: Wingdings">&#120;</FONT> (1)&nbsp;&nbsp;&nbsp;&nbsp;
    (b) <FONT STYLE="font-family: Wingdings">&#168;</FONT><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">3.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt"><P STYLE="margin-top: 0; margin-bottom: 0">SEC
                                            Use Only</P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">4.</TD>
    <TD STYLE="border-right: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Citizenship or Place of Organization</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Delaware</P></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
  <TR>
    <TD ROWSPAN="4" STYLE="border: Black 1pt solid; padding: 2.15pt 5.4pt; width: 13%"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Number of</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Shares</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Beneficially</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Owned by</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Each</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Reporting</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Person With</P></TD>
    <TD STYLE="border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; vertical-align: top; width: 5%; text-align: right">5.</TD>
    <TD STYLE="border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt; vertical-align: top; width: 82%"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Sole Voting Power</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">0</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">6.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Shared Voting Power</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">3,541,941 (2)</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">7.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Sole Dispositive Power</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">0</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">8.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Shared Dispositive Power</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">3,541,941 (2)</P></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; width: 5%; text-align: right">9.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt; width: 95%"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Aggregate Amount Beneficially Owned by Each Reporting Person</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">3,541,941 (2)</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">10.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt"><P STYLE="margin-top: 0; margin-bottom: 0">Check
                                            if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)&nbsp;&nbsp;&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">&#168;</FONT></P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">11.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Percent of Class Represented by Amount in Row (9)</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">9.99% (3)</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">12.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Type of Reporting Person (See Instructions)</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">PN</P></TD></TR>
  </TABLE>
<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0%"></TD><TD STYLE="width: 3%">(1)</TD><TD STYLE="text-align: justify; width: 97%">Venrock Healthcare Capital Partners
                                            III, L.P., VHCP Co-Investment Holdings III, LLC, Venrock Healthcare Capital Partners EG,
                                            L.P., VHCP Management III, LLC, VHCP Management EG, LLC, Nimish Shah and Bong Koh are members
                                            of a group for the purposes of this Schedule 13G/A.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0%"></TD><TD STYLE="width: 3%">(2)</TD><TD STYLE="text-align: justify; width: 97%">Consists of (i)&nbsp;668,656 shares
                                            and 79,502 shares issuable upon the exercise of Warrants held by Venrock Healthcare Capital
                                            Partners III, L.P.; (ii)&nbsp;66,890 shares and 9,742 shares issuable upon the exercise of
                                            Warrants held by VHCP Co-Investment Holdings III, LLC; and (iii)&nbsp;2,350,074 shares and
                                            367,077 shares issuable upon the exercise of Warrants held by Venrock Healthcare Capital
                                            Partners EG, L.P. The share numbers in the preceding sentence represent the maximum number
                                            of shares of common stock issuable upon exercise of the Warrants held by the Reporting Persons
                                            as a result of the beneficial ownership provision described in the following sentence. Under
                                            the terms of the Warrants, the Issuer may not effect the exercise of any such Warrant, and
                                            a holder will not be entitled to exercise any portion of such Warrant, if, upon giving effect
                                            to such exercise, the aggregate number of shares of common stock beneficially owned by the
                                            holder (together with its affiliates and other attribution parties) would exceed 9.99% of
                                            the number of shares of common stock outstanding immediately after giving effect to the exercise.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0%"></TD><TD STYLE="width: 3%">(3)</TD><TD STYLE="text-align: justify; width: 97%">This percentage is calculated based
                                            upon the sum of (i)&nbsp;34,998,550 shares of the Issuer&rsquo;s Common Stock outstanding
                                            as of September&nbsp;13, 2024, as reported in the Issuer&rsquo;s Current Report on Form&nbsp;8-K
                                            filed with the SEC on September&nbsp;13, 2024; and (ii)&nbsp;456,321 shares issuable upon
                                            the exercise of the Warrants described in Footnote 2 above.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%">
  <TR STYLE="vertical-align: bottom">
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif">CUSIP No.&nbsp;687604108&nbsp;</TD>
    <TD STYLE="text-align: right; font: bold 10pt Times New Roman, Times, Serif">Page&nbsp;5 of 14</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD STYLE="border: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; width: 5%; text-align: right">1.</TD>
    <TD STYLE="border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt; width: 95%"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Names of Reporting Persons</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">VHCP Management III, LLC</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">2.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Check the Appropriate Box if a Member of a Group (See Instructions)</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">(a) <FONT STYLE="font-family: Wingdings">&#120;</FONT> (1)&nbsp;&nbsp;&nbsp;&nbsp;
    (b) <FONT STYLE="font-family: Wingdings">&#168;</FONT><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">3.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt"><P STYLE="margin-top: 0; margin-bottom: 0">SEC
                                            Use Only</P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">4.</TD>
    <TD STYLE="border-right: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Citizenship or Place of Organization</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Delaware</P></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
  <TR>
    <TD ROWSPAN="4" STYLE="border: Black 1pt solid; padding: 2.15pt 5.4pt; width: 13%"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Number of</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Shares</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Beneficially</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Owned by</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Each</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Reporting</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Person With</P></TD>
    <TD STYLE="border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; vertical-align: top; width: 5%; text-align: right">5.</TD>
    <TD STYLE="border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt; vertical-align: top; width: 82%"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Sole Voting Power</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">0</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">6.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Shared Voting Power</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">3,541,941 (2)</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">7.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Sole Dispositive Power</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">0</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">8.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Shared Dispositive Power</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">3,541,941 (2)</P></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; width: 5%; text-align: right">9.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt; width: 95%"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Aggregate Amount Beneficially Owned by Each Reporting Person</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">3,541,941 (2)</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">10.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt"><P STYLE="margin-top: 0; margin-bottom: 0">Check
                                            if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)&nbsp;&nbsp;&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">&#168;</FONT></P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">11.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Percent of Class Represented by Amount in Row (9)</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">9.99% (3)</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">12.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Type of Reporting Person (See Instructions)</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">OO</P></TD></TR>
  </TABLE>
<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0%"></TD><TD STYLE="width: 3%">(1)</TD><TD STYLE="text-align: justify; width: 97%">Venrock Healthcare Capital Partners
                                            III, L.P., VHCP Co-Investment Holdings III, LLC, Venrock Healthcare Capital Partners EG,
                                            L.P., VHCP Management III, LLC, VHCP Management EG, LLC, Nimish Shah and Bong Koh are members
                                            of a group for the purposes of this Schedule 13G/A.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0%"></TD><TD STYLE="width: 3%">(2)</TD><TD STYLE="text-align: justify; width: 97%">Consists of (i)&nbsp;668,656 shares
                                            and 79,502 shares issuable upon the exercise of Warrants held by Venrock Healthcare Capital
                                            Partners III, L.P.; (ii)&nbsp;66,890 shares and 9,742 shares issuable upon the exercise of
                                            Warrants held by VHCP Co-Investment Holdings III, LLC; and (iii)&nbsp;2,350,074 shares and
                                            367,077 shares issuable upon the exercise of Warrants held by Venrock Healthcare Capital
                                            Partners EG, L.P. The share numbers in the preceding sentence represent the maximum number
                                            of shares of common stock issuable upon exercise of the Warrants held by the Reporting Persons
                                            as a result of the beneficial ownership provision described in the following sentence. Under
                                            the terms of the Warrants, the Issuer may not effect the exercise of any such Warrant, and
                                            a holder will not be entitled to exercise any portion of such Warrant, if, upon giving effect
                                            to such exercise, the aggregate number of shares of common stock beneficially owned by the
                                            holder (together with its affiliates and other attribution parties) would exceed 9.99% of
                                            the number of shares of common stock outstanding immediately after giving effect to the exercise.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0%"></TD><TD STYLE="width: 3%">(3)</TD><TD STYLE="text-align: justify; width: 97%">This percentage is calculated based
                                            upon the sum of (i)&nbsp;34,998,550 shares of the Issuer&rsquo;s Common Stock outstanding
                                            as of September&nbsp;13, 2024, as reported in the Issuer&rsquo;s Current Report on Form&nbsp;8-K
                                            filed with the SEC on September&nbsp;13, 2024; and (ii)&nbsp;456,321 shares issuable upon
                                            the exercise of the Warrants described in Footnote 2 above.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%">
  <TR STYLE="vertical-align: bottom">
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif">CUSIP No.&nbsp;687604108&nbsp;</TD>
    <TD STYLE="text-align: right; font: bold 10pt Times New Roman, Times, Serif">Page&nbsp;6 of 14</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD STYLE="border: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; width: 5%; text-align: right">1.</TD>
    <TD STYLE="border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt; width: 95%"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Names of Reporting Persons</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">VHCP Management EG, LLC</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">2.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Check the Appropriate Box if a Member of a Group (See Instructions)</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">(a) <FONT STYLE="font-family: Wingdings">&#120;</FONT> (1)&nbsp;&nbsp;&nbsp;&nbsp;
    (b) <FONT STYLE="font-family: Wingdings">&#168;</FONT><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">3.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt"><P STYLE="margin-top: 0; margin-bottom: 0">SEC
                                            Use Only</P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">4.</TD>
    <TD STYLE="border-right: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Citizenship or Place of Organization</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Delaware</P></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
  <TR>
    <TD ROWSPAN="4" STYLE="border: Black 1pt solid; padding: 2.15pt 5.4pt; width: 13%"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Number of</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Shares</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Beneficially</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Owned by</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Each</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Reporting</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Person With</P></TD>
    <TD STYLE="border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; vertical-align: top; width: 5%; text-align: right">5.</TD>
    <TD STYLE="border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt; vertical-align: top; width: 82%"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Sole Voting Power</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">0</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">6.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Shared Voting Power</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">3,541,941 (2)</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">7.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Sole Dispositive Power</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">0</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">8.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Shared Dispositive Power</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">3,541,941 (2)</P></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; width: 5%; text-align: right">9.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt; width: 95%"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Aggregate Amount Beneficially Owned by Each Reporting Person</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">3,541,941 (2)</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">10.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt"><P STYLE="margin-top: 0; margin-bottom: 0">Check
                                            if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)&nbsp;&nbsp;&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">&#168;</FONT></P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">11.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Percent of Class Represented by Amount in Row (9)</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">9.99% (3)</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">12.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Type of Reporting Person (See Instructions)</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">OO</P></TD></TR>
  </TABLE>
<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0%"></TD><TD STYLE="width: 3%">(1)</TD><TD STYLE="text-align: justify; width: 97%">Venrock Healthcare Capital Partners
                                            III, L.P., VHCP Co-Investment Holdings III, LLC, Venrock Healthcare Capital Partners EG,
                                            L.P., VHCP Management III, LLC, VHCP Management EG, LLC, Nimish Shah and Bong Koh are members
                                            of a group for the purposes of this Schedule 13G/A.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0%"></TD><TD STYLE="width: 3%">(2)</TD><TD STYLE="text-align: justify; width: 97%">Consists of (i)&nbsp;668,656 shares
                                            and 79,502 shares issuable upon the exercise of Warrants held by Venrock Healthcare Capital
                                            Partners III, L.P.; (ii)&nbsp;66,890 shares and 9,742 shares issuable upon the exercise of
                                            Warrants held by VHCP Co-Investment Holdings III, LLC; and (iii)&nbsp;2,350,074 shares and
                                            367,077 shares issuable upon the exercise of Warrants held by Venrock Healthcare Capital
                                            Partners EG, L.P. The share numbers in the preceding sentence represent the maximum number
                                            of shares of common stock issuable upon exercise of the Warrants held by the Reporting Persons
                                            as a result of the beneficial ownership provision described in the following sentence. Under
                                            the terms of the Warrants, the Issuer may not effect the exercise of any such Warrant, and
                                            a holder will not be entitled to exercise any portion of such Warrant, if, upon giving effect
                                            to such exercise, the aggregate number of shares of common stock beneficially owned by the
                                            holder (together with its affiliates and other attribution parties) would exceed 9.99% of
                                            the number of shares of common stock outstanding immediately after giving effect to the exercise.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0%"></TD><TD STYLE="width: 3%">(3)</TD><TD STYLE="text-align: justify; width: 97%">This percentage is calculated based
                                            upon the sum of (i)&nbsp;34,998,550 shares of the Issuer&rsquo;s Common Stock outstanding
                                            as of September&nbsp;13, 2024, as reported in the Issuer&rsquo;s Current Report on Form&nbsp;8-K
                                            filed with the SEC on September&nbsp;13, 2024; and (ii)&nbsp;456,321 shares issuable upon
                                            the exercise of the Warrants described in Footnote 2 above.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%">
  <TR STYLE="vertical-align: bottom">
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif">CUSIP No.&nbsp;687604108&nbsp;</TD>
    <TD STYLE="text-align: right; font: bold 10pt Times New Roman, Times, Serif">Page&nbsp;7 of 14</TD></TR>
  </TABLE>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD STYLE="border: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; width: 5%; text-align: right">1.</TD>
    <TD STYLE="border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt; width: 95%"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Names of Reporting Persons</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Shah, Nimish</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">2.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Check the Appropriate Box if a Member of a Group (See Instructions)</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">(a) <FONT STYLE="font-family: Wingdings">&#120;</FONT> (1)&nbsp;&nbsp;&nbsp;&nbsp;
    (b) <FONT STYLE="font-family: Wingdings">&#168;</FONT><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">3.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt"><P STYLE="margin-top: 0; margin-bottom: 0">SEC
                                            Use Only</P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">4.</TD>
    <TD STYLE="border-right: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Citizenship or Place of Organization</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">United States</P></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
  <TR>
    <TD ROWSPAN="4" STYLE="border: Black 1pt solid; padding: 2.15pt 5.4pt; width: 13%"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Number of</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Shares</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Beneficially</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Owned by</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Each</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Reporting</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Person With</P></TD>
    <TD STYLE="border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; vertical-align: top; width: 5%; text-align: right">5.</TD>
    <TD STYLE="border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt; vertical-align: top; width: 82%"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Sole Voting Power</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">0</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">6.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Shared Voting Power</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">3,541,941 (2)</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">7.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Sole Dispositive Power</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">0</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">8.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Shared Dispositive Power</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">3,541,941 (2)</P></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; width: 5%; text-align: right">9.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt; width: 95%"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Aggregate Amount Beneficially Owned by Each Reporting Person</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">3,541,941 (2)</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">10.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt"><P STYLE="margin-top: 0; margin-bottom: 0">Check
                                            if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)&nbsp;&nbsp;&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">&#168;</FONT></P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">11.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Percent of Class Represented by Amount in Row (9)</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">9.99% (3)</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">12.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Type of Reporting Person (See Instructions)</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">IN</P></TD></TR>
  </TABLE>
<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0%"></TD><TD STYLE="width: 3%">(1)</TD><TD STYLE="text-align: justify; width: 97%">Venrock Healthcare Capital Partners
                                            III, L.P., VHCP Co-Investment Holdings III, LLC, Venrock Healthcare Capital Partners EG,
                                            L.P., VHCP Management III, LLC, VHCP Management EG, LLC, Nimish Shah and Bong Koh are members
                                            of a group for the purposes of this Schedule 13G/A.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0%"></TD><TD STYLE="width: 3%">(2)</TD><TD STYLE="text-align: justify; width: 97%">Consists of (i)&nbsp;668,656 shares
                                            and 79,502 shares issuable upon the exercise of Warrants held by Venrock Healthcare Capital
                                            Partners III, L.P.; (ii)&nbsp;66,890 shares and 9,742 shares issuable upon the exercise of
                                            Warrants held by VHCP Co-Investment Holdings III, LLC; and (iii)&nbsp;2,350,074 shares and
                                            367,077 shares issuable upon the exercise of Warrants held by Venrock Healthcare Capital
                                            Partners EG, L.P. The share numbers in the preceding sentence represent the maximum number
                                            of shares of common stock issuable upon exercise of the Warrants held by the Reporting Persons
                                            as a result of the beneficial ownership provision described in the following sentence. Under
                                            the terms of the Warrants, the Issuer may not effect the exercise of any such Warrant, and
                                            a holder will not be entitled to exercise any portion of such Warrant, if, upon giving effect
                                            to such exercise, the aggregate number of shares of common stock beneficially owned by the
                                            holder (together with its affiliates and other attribution parties) would exceed 9.99% of
                                            the number of shares of common stock outstanding immediately after giving effect to the exercise.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0%"></TD><TD STYLE="width: 3%">(3)</TD><TD STYLE="text-align: justify; width: 97%">This percentage is calculated based
                                            upon the sum of (i)&nbsp;34,998,550 shares of the Issuer&rsquo;s Common Stock outstanding
                                            as of September&nbsp;13, 2024, as reported in the Issuer&rsquo;s Current Report on Form&nbsp;8-K
                                            filed with the SEC on September&nbsp;13, 2024; and (ii)&nbsp;456,321 shares issuable upon
                                            the exercise of the Warrants described in Footnote 2 above.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%">
  <TR STYLE="vertical-align: bottom">
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif">CUSIP No.&nbsp;687604108&nbsp;</TD>
    <TD STYLE="text-align: right; font: bold 10pt Times New Roman, Times, Serif">Page&nbsp;8 of 14</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="margin-top: 0; margin-bottom: 0"></P>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD STYLE="border: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; width: 5%; text-align: right">1.</TD>
    <TD STYLE="border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt; width: 95%"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Names of Reporting Persons</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Koh, Bong</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">2.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Check the Appropriate Box if a Member of a Group (See Instructions)</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">(a) <FONT STYLE="font-family: Wingdings">&#120;</FONT> (1)&nbsp;&nbsp;&nbsp;&nbsp;
    (b) <FONT STYLE="font-family: Wingdings">&#168;</FONT><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">3.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt"><P STYLE="margin-top: 0; margin-bottom: 0">SEC
                                            Use Only</P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">4.</TD>
    <TD STYLE="border-right: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Citizenship or Place of Organization</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">United States</P></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
  <TR>
    <TD ROWSPAN="4" STYLE="border: Black 1pt solid; padding: 2.15pt 5.4pt; width: 13%"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Number of</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Shares</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Beneficially</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Owned by</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Each</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Reporting</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 1.2pt">Person With</P></TD>
    <TD STYLE="border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; vertical-align: top; width: 5%; text-align: right">5.</TD>
    <TD STYLE="border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt; vertical-align: top; width: 82%"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Sole Voting Power</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">0</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">6.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Shared Voting Power</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">3,541,941 (2)</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">7.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Sole Dispositive Power</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">0</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">8.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Shared Dispositive Power</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">3,541,941 (2)</P></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; width: 5%; text-align: right">9.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt; width: 95%"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Aggregate Amount Beneficially Owned by Each Reporting Person</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">3,541,941 (2)</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">10.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt"><P STYLE="margin-top: 0; margin-bottom: 0">Check
                                            if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)&nbsp;&nbsp;&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">&#168;</FONT></P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">11.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Percent of Class Represented by Amount in Row (9)</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">9.99% (3)</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 10pt Times New Roman,serif; padding: 2.15pt 5.4pt 2.15pt 0.05in; text-align: right">12.</TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 2.15pt 5.4pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Type of Reporting Person (See Instructions)</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">IN</P></TD></TR>
  </TABLE>
<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0%"></TD><TD STYLE="width: 3%">(1)</TD><TD STYLE="text-align: justify; width: 97%">Venrock Healthcare Capital Partners
                                            III, L.P., VHCP Co-Investment Holdings III, LLC, Venrock Healthcare Capital Partners EG,
                                            L.P., VHCP Management III, LLC, VHCP Management EG, LLC, Nimish Shah and Bong Koh are members
                                            of a group for the purposes of this Schedule 13G/A.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0%"></TD><TD STYLE="width: 3%">(2)</TD><TD STYLE="text-align: justify; width: 97%">Consists of (i)&nbsp;668,656 shares
                                            and 79,502 shares issuable upon the exercise of Warrants held by Venrock Healthcare Capital
                                            Partners III, L.P.; (ii)&nbsp;66,890 shares and 9,742 shares issuable upon the exercise of
                                            Warrants held by VHCP Co-Investment Holdings III, LLC; and (iii)&nbsp;2,350,074 shares and
                                            367,077 shares issuable upon the exercise of Warrants held by Venrock Healthcare Capital
                                            Partners EG, L.P. The share numbers in the preceding sentence represent the maximum number
                                            of shares of common stock issuable upon exercise of the Warrants held by the Reporting Persons
                                            as a result of the beneficial ownership provision described in the following sentence. Under
                                            the terms of the Warrants, the Issuer may not effect the exercise of any such Warrant, and
                                            a holder will not be entitled to exercise any portion of such Warrant, if, upon giving effect
                                            to such exercise, the aggregate number of shares of common stock beneficially owned by the
                                            holder (together with its affiliates and other attribution parties) would exceed 9.99% of
                                            the number of shares of common stock outstanding immediately after giving effect to the exercise.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0%"></TD><TD STYLE="width: 3%">(3)</TD><TD STYLE="text-align: justify; width: 97%">This percentage is calculated based
                                            upon the sum of (i)&nbsp;34,998,550 shares of the Issuer&rsquo;s Common Stock outstanding
                                            as of September&nbsp;13, 2024, as reported in the Issuer&rsquo;s Current Report on Form&nbsp;8-K
                                            filed with the SEC on September&nbsp;13, 2024; and (ii)&nbsp;456,321 shares issuable upon
                                            the exercise of the Warrants described in Footnote 2 above.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%">
  <TR STYLE="vertical-align: bottom">
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif">CUSIP No.&nbsp;687604108&nbsp;</TD>
    <TD STYLE="text-align: right; font: bold 10pt Times New Roman, Times, Serif">Page&nbsp;9 of 14</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="text-align: justify; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Introductory
Note:&nbsp;&nbsp;</B></FONT>This Schedule 13G/A is filed on behalf of Venrock Healthcare Capital Partners III, L.P., a limited partnership
organized under the laws of the State of Delaware (&ldquo;<B><I>VHCP III LP</I></B>&rdquo;), VHCP Co-Investment Holdings III, LLC, a
limited liability company organized under the laws of the State of Delaware (&ldquo;<B><I>VHCP Co-Investment III</I></B>&rdquo;), Venrock
Healthcare Capital Partners EG, L.P., a limited partnership organized under the laws of the State of Delaware (&ldquo;<B><I>VHCP EG</I></B>&rdquo;),
VHCP Management III, LLC, a limited liability company organized under the laws of the State of Delaware (&ldquo;<B><I>VHCP Management
III</I></B>&rdquo;), VHCP Management EG, LLC, a limited liability company organized under the laws of the State of Delaware (&ldquo;<B><I>VHCP
Management EG</I></B>&rdquo; and collectively with VHCP III LP, VHCP Co-Investment III, VHCP EG and VHCP Management III, the &ldquo;<B><I>Venrock
Entities</I></B>&rdquo;), Nimish Shah (&ldquo;<B><I>Shah</I></B>&rdquo;) and Bong Koh (&ldquo;<B><I>Koh</I></B>&rdquo;) in respect of
the Common Stock of Oruka Therapeutics,&nbsp;Inc. (f/k/a ARCA biopharma,&nbsp;Inc.).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman,serif; padding-top: 2.15pt; padding-bottom: 2.15pt"><B>Item 1.</B></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="font: 10pt Times New Roman,serif; width: 9%; padding-top: 2.15pt; padding-bottom: 10pt">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; width: 4%; padding-top: 2.15pt; padding-bottom: 10pt">(a)</TD>
    <TD STYLE="width: 87%; padding-top: 2.15pt; padding-bottom: 2.15pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Name of Issuer</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Oruka Therapeutics,&nbsp;Inc.</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="3" STYLE="font: 6pt Times New Roman,serif; padding-top: 2.15pt; padding-bottom: 2.15pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="font: 10pt Times New Roman,serif; padding-top: 2.15pt; padding-bottom: 10pt">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; padding-top: 2.15pt; padding-bottom: 10pt">(b)</TD>
    <TD STYLE="padding-top: 2.15pt; padding-bottom: 2.15pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Address of Issuer&rsquo;s Principal Executive Offices</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">885 Oak Grove Avenue, Suite&nbsp;100</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Menlo Park, CA 94025</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="3" STYLE="font: 6pt Times New Roman,serif; padding-top: 2.15pt; padding-bottom: 2.15pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman,serif; padding-top: 2.15pt; padding-bottom: 2.15pt"><B>Item 2.</B></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="font: 10pt Times New Roman,serif; padding-top: 2.15pt; padding-bottom: 10pt">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; padding-top: 2.15pt; padding-bottom: 10pt">(a)</TD>
    <TD STYLE="padding-top: 2.15pt; padding-bottom: 2.15pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Name of Person Filing</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Venrock Healthcare Capital Partners III, L.P.</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">VHCP Co-Investment Holdings III, LLC</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Venrock Healthcare Capital Partners EG, L.P.</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">VHCP Management III, LLC</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">VHCP Management EG, LLC</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Nimish Shah</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Bong Koh&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0"></P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="font: 10pt Times New Roman,serif; padding-top: 2.15pt; padding-bottom: 10pt">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; padding-top: 2.15pt; padding-bottom: 10pt">(b)</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; padding-top: 2.15pt; padding-bottom: 6pt">Address of Principal Business Office or, if
    none, Residence</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 14%; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="width: 24%; font-family: Times New Roman,serif">New York Office:</TD>
    <TD STYLE="width: 64%; font-family: Times New Roman,serif">Palo Alto Office:</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">7 Bryant Park</TD>
    <TD STYLE="font-family: Times New Roman,serif">3340 Hillview Avenue</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">23rd Floor</TD>
    <TD STYLE="font-family: Times New Roman,serif">Palo Alto, CA 94304</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">New York, NY 10018</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 2.15pt; padding-bottom: 10pt; width: 9%; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="padding-top: 2.15pt; padding-bottom: 10pt; width: 4%; font-family: Times New Roman,serif">(c)</TD>
    <TD STYLE="padding-top: 2.15pt; padding-bottom: 2.15pt; width: 87%"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Citizenship</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0; text-align: justify">All of the Venrock Entities were organized in Delaware.
    The individuals are both United States citizens.</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="3" STYLE="font: 6pt Times New Roman,serif; padding-top: 2.15pt; padding-bottom: 2.15pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 2.15pt; padding-bottom: 10pt; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="padding-top: 2.15pt; padding-bottom: 10pt; font-family: Times New Roman,serif">(d)</TD>
    <TD STYLE="padding-top: 2.15pt; padding-bottom: 2.15pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Title of Class of Securities</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">Common Stock, $0.001 par value</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 2.15pt; padding-bottom: 10pt; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="padding-top: 2.15pt; padding-bottom: 10pt; font-family: Times New Roman,serif">(e)</TD>
    <TD STYLE="padding-top: 2.15pt; padding-bottom: 2.15pt"><P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">CUSIP Number</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">687604108</P></TD></TR>
</TABLE>

<P STYLE="margin: 0">&nbsp;</P>

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    <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%">
  <TR STYLE="vertical-align: bottom">
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif">CUSIP No.&nbsp;687604108&nbsp;</TD>
    <TD STYLE="text-align: right; font: bold 10pt Times New Roman, Times, Serif">Page&nbsp;10 of 14</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="3" STYLE="font: 6pt Times New Roman,serif; padding-top: 2.15pt; padding-bottom: 2.15pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 2.15pt; padding-bottom: 2.15pt; font-family: Times New Roman,serif"><B>Item 3.</B></TD>
    <TD COLSPAN="2" STYLE="padding-top: 2.15pt; padding-bottom: 3pt; font-family: Times New Roman,serif"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>If
    this statement is filed pursuant to &sect;&sect;240.13d-1(b)&nbsp;or 240.13d-2(b)&nbsp;or (c), check whether the person filing is
    a:</B></FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 2.15pt; padding-bottom: 2.15pt; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-top: 2.15pt; padding-bottom: 2.15pt; font-family: Times New Roman,serif">Not applicable</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="3" STYLE="font: 6pt Times New Roman,serif; padding-top: 2.15pt; padding-bottom: 2.15pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 2.15pt; padding-bottom: 2.15pt; font-family: Times New Roman,serif"><B>Item 4.</B></TD>
    <TD COLSPAN="2" STYLE="padding-top: 2.15pt; padding-bottom: 2.15pt; font-family: Times New Roman,serif"><B>Ownership</B></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 2.15pt; padding-bottom: 6pt; font-family: Times New Roman,serif; width: 9%">&nbsp;</TD>
    <TD STYLE="padding-top: 2.15pt; padding-bottom: 6pt; font-family: Times New Roman,serif; width: 4%">(a)</TD>
    <TD STYLE="padding-top: 2.15pt; padding-bottom: 6pt; font-family: Times New Roman,serif; width: 87%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Amount
    beneficially owned as of September&nbsp;30, 2024: </FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" ALIGN="CENTER" STYLE="border-collapse: collapse; width: 80%; font-size: 10pt">
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="background-color: White; width: 13%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 75%; text-align: left">Venrock Healthcare Capital Partners III, L.P.</TD><TD STYLE="width: 1%; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="width: 1%; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 9%; text-align: right"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">3,541,941</FONT></TD>
                                                                                                 <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">
                                                                                                 &nbsp;(1)</FONT></TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="background-color: White">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">VHCP Co-Investment Holdings III, LLC</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">3,541,941</FONT></TD>
                                                                                      <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;(1)</FONT></TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="background-color: White">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Venrock Healthcare Capital Partners EG, L.P.</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">3,541,941</FONT></TD>
                                                                                      <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;(1)</FONT></TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="background-color: White">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">VHCP Management III, LLC</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">3,541,941</FONT></TD>
                                                                                      <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;(1)</FONT></TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="background-color: White">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">VHCP Management EG, LLC</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">3,541,941</FONT></TD>
                                                                                      <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;(1)</FONT></TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="background-color: White">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Nimish Shah</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">3,541,941</FONT></TD>
                                                                                      <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;(1)</FONT></TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="background-color: White">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Bong Koh</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">3,541,941</FONT></TD>
                                                                                      <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;(1)</FONT></TD></TR>
  </TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 9%; padding-top: 2.15pt; padding-bottom: 6pt; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="width: 4%; padding-top: 2.15pt; padding-bottom: 6pt; font-family: Times New Roman,serif">(b)</TD>
    <TD STYLE="width: 87%; padding-top: 2.15pt; padding-bottom: 6pt; font-family: Times New Roman,serif"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Percent
    of class as of September&nbsp;30, 2024: </FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" ALIGN="CENTER" STYLE="border-collapse: collapse; width: 80%; font-size: 10pt">
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="background-color: White; width: 13%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 74%; text-align: left">Venrock Healthcare Capital Partners III, L.P.</TD><TD STYLE="width: 1%; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="width: 1%; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 9%; text-align: right"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">9.99</FONT></TD>
                                                                                                 <TD STYLE="font: 10pt Times New Roman, Times, Serif; white-space: nowrap; width: 2%; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">%&nbsp;(2)</FONT></TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="background-color: White">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">VHCP Co-Investment Holdings III, LLC</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">9.99</FONT></TD>
                                                                                      <TD STYLE="font: 10pt Times New Roman, Times, Serif; white-space: nowrap; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">%&nbsp;(2)</FONT></TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="background-color: White">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Venrock Healthcare Capital Partners EG, L.P.</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">9.99</FONT></TD>
                                                                                      <TD STYLE="font: 10pt Times New Roman, Times, Serif; white-space: nowrap; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">%&nbsp;(2)</FONT></TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="background-color: White">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">VHCP Management III, LLC</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">9.99</FONT></TD>
                                                                                      <TD STYLE="font: 10pt Times New Roman, Times, Serif; white-space: nowrap; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">%&nbsp;(2)</FONT></TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="background-color: White">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">VHCP Management EG, LLC</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">9.99</FONT></TD>
                                                                                      <TD STYLE="font: 10pt Times New Roman, Times, Serif; white-space: nowrap; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">%&nbsp;(2)</FONT></TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="background-color: White">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Nimish Shah</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">9.99</FONT></TD>
                                                                                      <TD STYLE="font: 10pt Times New Roman, Times, Serif; white-space: nowrap; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">%&nbsp;(2)</FONT></TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="background-color: White">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Bong Koh</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">9.99</FONT></TD>
                                                                                      <TD STYLE="font: 10pt Times New Roman, Times, Serif; white-space: nowrap; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">%&nbsp;(2)</FONT></TD></TR>
  </TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 2.15pt; padding-bottom: 6pt; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="padding-top: 2.15pt; padding-bottom: 6pt; font-family: Times New Roman,serif">(c)</TD>
    <TD COLSPAN="2" STYLE="padding-top: 2.15pt; padding-bottom: 6pt; font-family: Times New Roman,serif">Number of shares as to which
    the person has, as of September&nbsp;30, 2024:</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 9%; padding-top: 2.15pt; padding-bottom: 6pt; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="width: 4%; padding-top: 2.15pt; padding-bottom: 6pt; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="width: 5%; padding-top: 2.15pt; padding-bottom: 6pt; font-family: Times New Roman,serif">(i)</TD>
    <TD STYLE="width: 82%; padding-top: 2.15pt; padding-bottom: 6pt; font-family: Times New Roman,serif"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Sole
    power to vote or to direct the vote: </FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" ALIGN="CENTER" STYLE="border-collapse: collapse; width: 80%; font-size: 10pt">
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="background-color: White; width: 13%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 75%; text-align: left">Venrock Healthcare Capital Partners III, L.P.</TD><TD STYLE="width: 1%; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="width: 1%; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="width: 9%; font: 10pt Times New Roman, Times, Serif; text-align: right">0</TD><TD STYLE="width: 1%; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="background-color: White">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">VHCP Co-Investment Holdings III, LLC</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">0</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="background-color: White">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Venrock Healthcare Capital Partners EG, L.P.</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">0</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="background-color: White">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">VHCP Management III, LLC</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">0</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="background-color: White">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">VHCP Management EG, LLC</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">0</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="background-color: White">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Nimish Shah</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">0</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="background-color: White">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Bong Koh</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">0</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
  </TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%">
  <TR STYLE="vertical-align: bottom">
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif">CUSIP No.&nbsp;687604108&nbsp;</TD>
    <TD STYLE="text-align: right; font: bold 10pt Times New Roman, Times, Serif">Page&nbsp;11 of 14</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 9%; padding-top: 2.15pt; padding-bottom: 6pt; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="width: 4%; padding-top: 2.15pt; padding-bottom: 6pt; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="width: 5%; padding-top: 2.15pt; padding-bottom: 6pt; font-family: Times New Roman,serif">(ii)</TD>
    <TD STYLE="width: 82%; padding-top: 2.15pt; padding-bottom: 6pt; font-family: Times New Roman,serif"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Shared
    power to vote or to direct the vote: </FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" ALIGN="CENTER" STYLE="border-collapse: collapse; width: 80%; font-size: 10pt">
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="background-color: White; width: 13%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 74%; text-align: left">Venrock Healthcare Capital Partners III, L.P.</TD><TD STYLE="width: 1%; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="width: 1%; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 9%; text-align: right"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">3,541,941</FONT></TD>
                                                                                                 <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 2%; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;(1)</FONT></TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="background-color: White">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">VHCP Co-Investment Holdings III, LLC</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">3,541,941</FONT></TD>
                                                                                      <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;(1)</FONT></TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="background-color: White">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Venrock Healthcare Capital Partners EG, L.P.</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">3,541,941</FONT></TD>
                                                                                      <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;(1)</FONT></TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="background-color: White">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">VHCP Management III, LLC</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">3,541,941</FONT></TD>
                                                                                      <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;(1)</FONT></TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="background-color: White">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">VHCP Management EG, LLC</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">3,541,941</FONT></TD>
                                                                                      <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;(1)</FONT></TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="background-color: White">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Nimish Shah</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">3,541,941</FONT></TD>
                                                                                      <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;(1)</FONT></TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="background-color: White">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Bong Koh</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">3,541,941</FONT></TD>
                                                                                      <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;(1)</FONT></TD></TR>
  </TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 9%; padding-top: 2.15pt; padding-bottom: 6pt; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="width: 4%; padding-top: 2.15pt; padding-bottom: 6pt; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="width: 5%; padding-top: 2.15pt; padding-bottom: 6pt; font-family: Times New Roman,serif">(iii)</TD>
    <TD STYLE="width: 82%; padding-top: 2.15pt; padding-bottom: 6pt; font-family: Times New Roman,serif"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Sole
    power to dispose or to direct the disposition of: </FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" ALIGN="CENTER" STYLE="border-collapse: collapse; width: 80%; font-size: 10pt">
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="background-color: White; width: 13%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 75%; text-align: left">Venrock Healthcare Capital Partners III, L.P.</TD><TD STYLE="width: 1%; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="width: 1%; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="width: 9%; font: 10pt Times New Roman, Times, Serif; text-align: right">0</TD><TD STYLE="width: 1%; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="background-color: White">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">VHCP Co-Investment Holdings III, LLC</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">0</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="background-color: White">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Venrock Healthcare Capital Partners EG, L.P.</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">0</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="background-color: White">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">VHCP Management III, LLC</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">0</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="background-color: White">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">VHCP Management EG, LLC</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">0</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="background-color: White">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Nimish Shah</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">0</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="background-color: White">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Bong Koh</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right">0</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
  </TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 9%; padding: 2.15pt 5.4pt 6pt; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="width: 4%; padding: 2.15pt 5.4pt 6pt; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="width: 5%; padding: 2.15pt 5.4pt 6pt; font-family: Times New Roman,serif">(iv)</TD>
    <TD STYLE="width: 82%; padding: 2.15pt 5.4pt 6pt; font-family: Times New Roman,serif"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Shared
    power to dispose or to direct the disposition of: </FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" ALIGN="CENTER" STYLE="border-collapse: collapse; width: 80%; font-size: 10pt">
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="background-color: White; width: 13%">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 75%; text-align: left">Venrock Healthcare Capital Partners III, L.P.</TD><TD STYLE="width: 1%; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="width: 1%; font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 9%; text-align: right"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">3,541,941</FONT></TD>
                                                                                                 <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 1%; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;(1)</FONT></TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="background-color: White">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">VHCP Co-Investment Holdings III, LLC</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">3,541,941</FONT></TD>
                                                                                      <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">
                                                                                      &nbsp;(1)</FONT></TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="background-color: White">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Venrock Healthcare Capital Partners EG, L.P.</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">3,541,941</FONT></TD>
                                                                                      <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;(1)</FONT></TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="background-color: White">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">VHCP Management III, LLC</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">3,541,941</FONT></TD>
                                                                                      <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;(1)</FONT></TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="background-color: White">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">VHCP Management EG, LLC</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">3,541,941</FONT></TD>
                                                                                      <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;(1)</FONT></TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="background-color: White">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Nimish Shah</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">3,541,941</FONT></TD>
                                                                                      <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;(1)</FONT></TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="background-color: White">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Bong Koh</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: right"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">3,541,941</FONT></TD>
                                                                                      <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;(1)</FONT></TD></TR>
  </TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;&nbsp;</P>

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    <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%">
  <TR STYLE="vertical-align: bottom">
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif">CUSIP No.&nbsp;687604108&nbsp;</TD>
    <TD STYLE="text-align: right; font: bold 10pt Times New Roman, Times, Serif">Page&nbsp;12 of 14</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman,serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 48.6pt"></TD><TD STYLE="width: 22.5pt">(1)</TD><TD STYLE="text-align: justify">Consists of (i)&nbsp;668,656 shares and
                                            79,502 shares issuable upon the exercise of Warrants held by Venrock Healthcare Capital Partners
                                            III, L.P.; (ii)&nbsp;66,890 shares and 9,742 shares issuable upon the exercise of Warrants
                                            held by VHCP Co-Investment Holdings III, LLC; and (iii)&nbsp;2,350,074 shares and 367,077
                                            shares issuable upon the exercise of Warrants held by Venrock Healthcare Capital Partners
                                            EG, L.P. The share numbers in the preceding sentence represent the maximum number of shares
                                            of common stock issuable upon exercise of the Warrants held by the Reporting Persons as a
                                            result of the beneficial ownership provision described in the following sentence. Under the
                                            terms of the Warrants, the Issuer may not effect the exercise of any such Warrant, and a
                                            holder will not be entitled to exercise any portion of such Warrant, if, upon giving effect
                                            to such exercise, the aggregate number of shares of common stock beneficially owned by the
                                            holder (together with its affiliates and other attribution parties) would exceed 9.99% of
                                            the number of shares of common stock outstanding immediately after giving effect to the exercise.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman,serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 71.1pt; text-align: justify; text-indent: 0pt">VHCP Management III, LLC
is the general partner of Venrock Healthcare Capital Partners III, L.P. and the manager of VHCP Co-Investment Holdings III, LLC. VHCP
Management EG, LLC is the general partner of Venrock Healthcare Capital Partners EG, L.P. Messrs.&nbsp;Shah and Koh are the voting members
of VHCP Management III, LLC and VHCP Management EG, LLC.</P>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0 0pt 71.1pt; text-align: justify; text-indent: 0pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman,serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 48.6pt"></TD><TD STYLE="width: 22.5pt">(2)</TD><TD STYLE="text-align: justify">This percentage is calculated based
                                            upon the sum of (i)&nbsp;34,998,550 shares of the Issuer&rsquo;s Common Stock outstanding
                                            as of September&nbsp;13, 2024, as reported in the Issuer&rsquo;s Current Report on Form&nbsp;8-K
                                            filed with the SEC on September&nbsp;13, 2024; and (ii)&nbsp;456,321 shares issuable upon
                                            the exercise of the Warrants described in Footnote 1 above.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman,serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 2.15pt; width: 7.5%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Item 5.</B></FONT></TD>
    <TD STYLE="padding-top: 2.15pt; width: 92.5%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Ownership of Five Percent
    or Less of a Class</B></FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 2.15pt">&nbsp;</TD>
    <TD STYLE="padding-top: 2.15pt; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">If
    this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial
    owner of more than five percent of the class of securities, check the following&nbsp;&nbsp;&nbsp;</FONT><FONT STYLE="font-family: Wingdings; font-size: 10pt; color: Black">&#168;</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="padding-top: 2.15pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 2.15pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Item 6.</B></FONT></TD>
    <TD STYLE="padding-top: 2.15pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Ownership of More than
    Five Percent on Behalf of Another Person</B></FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 2.15pt">&nbsp;</TD>
    <TD STYLE="padding-top: 2.15pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Not applicable</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="padding-top: 2.15pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 2.15pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Item 7.</B></FONT></TD>
    <TD STYLE="text-align: justify; padding-top: 2.15pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Identification and Classification
    of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person</B></FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 2.15pt">&nbsp;</TD>
    <TD STYLE="padding-top: 2.15pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Not applicable</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="padding-top: 2.15pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 2.15pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Item 8.</B></FONT></TD>
    <TD STYLE="padding-top: 2.15pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Identification and Classification
    of Members of the Group</B></FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 2.15pt">&nbsp;</TD>
    <TD STYLE="padding-top: 2.15pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Not applicable</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="padding-top: 2.15pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 2.15pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Item 9.</B></FONT></TD>
    <TD STYLE="padding-top: 2.15pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Notice of Dissolution
    of Group</B></FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 2.15pt">&nbsp;</TD>
    <TD STYLE="padding-top: 2.15pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Not applicable</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="padding-top: 2.15pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 2.15pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Item 10.</B></FONT></TD>
    <TD STYLE="padding-top: 2.15pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Certification</B></FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-top: 2.15pt">&nbsp;</TD>
    <TD STYLE="padding-top: 2.15pt; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">By
    signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are
    not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not
    acquired and are not held in connection with or as a participant in any transaction having such purpose or effect.</FONT></TD></TR>
  </TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<!-- Field: Page; Sequence: 12 -->
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    <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%">
  <TR STYLE="vertical-align: bottom">
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif">CUSIP No.&nbsp;687604108&nbsp;</TD>
    <TD STYLE="text-align: right; font: bold 10pt Times New Roman, Times, Serif">Page&nbsp;13 of 14</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SIGNATURE</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">After reasonable inquiry and to the best of my
knowledge and belief,&nbsp;I certify that the information set forth in this statement is true, complete and correct.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Dated: November&nbsp;14, 2024</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif"><B>Venrock Healthcare Capital Partners III, L.P.</B></TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif"><B>Venrock Healthcare Capital Partners EG, L.P.</B></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif; width: 3%">By:</TD>
    <TD STYLE="font-family: Times New Roman,serif; width: 45%">VHCP Management III, LLC</TD>
    <TD STYLE="width: 4%">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif; width: 3%">By:</TD>
    <TD STYLE="font-family: Times New Roman,serif; width: 45%">VHCP Management EG, LLC</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">Its:</TD>
    <TD STYLE="font-family: Times New Roman,serif">General Partner</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">Its:</TD>
    <TD STYLE="font-family: Times New Roman,serif">General Partner</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">By:</TD>
    <TD STYLE="border-bottom: Black thin solid; font-family: Times New Roman,serif">/s/ Sherman G. Souther</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">By:</TD>
    <TD STYLE="border-bottom: Black thin solid; font-family: Times New Roman,serif">/s/ Sherman G. Souther</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">Name: Sherman G. Souther</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">Name: Sherman G. Souther</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">Its: Authorized Signatory</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">Its: Authorized Signatory</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif"><B>VHCP Co-Investment Holdings III, LLC</B></TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">By:</TD>
    <TD STYLE="font-family: Times New Roman,serif">VHCP Management III, LLC</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">Its:</TD>
    <TD STYLE="font-family: Times New Roman,serif">Manager</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">By:</TD>
    <TD STYLE="border-bottom: Black thin solid; font-family: Times New Roman,serif">/s/ Sherman G. Souther</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">Name: Sherman G. Souther</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">Its: Authorized Signatory</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif"><B>VHCP Management III, LLC</B></TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif"><B>VHCP Management EG, LLC</B></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">By:</TD>
    <TD STYLE="border-bottom: Black thin solid; font-family: Times New Roman,serif">/s/ Sherman G. Souther</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">By:</TD>
    <TD STYLE="border-bottom: Black thin solid; font-family: Times New Roman,serif">/s/ Sherman G. Souther</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">Name: Sherman G. Souther</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">Name: Sherman G. Souther</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">Its: Authorized Signatory</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">Its: Authorized Signatory</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif"><B>Nimish Shah</B></TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="border-bottom: Black thin solid; font-family: Times New Roman,serif">/s/ Sherman G. Souther</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">Sherman G. Souther, Attorney-in-fact</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif"><B>Bong Koh</B></TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="border-bottom: Black thin solid; font-family: Times New Roman,serif">/s/ Sherman G. Souther</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">Sherman G. Souther, Attorney-in-fact</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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  <TR STYLE="vertical-align: bottom">
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif">CUSIP No.&nbsp;687604108&nbsp;</TD>
    <TD STYLE="text-align: right; font: bold 10pt Times New Roman, Times, Serif">Page&nbsp;14 of 14</TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>EXHIBITS</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in"><A HREF="https://www.sec.gov/Archives/edgar/data/907654/000110465924054266/tm2412836d2_sc13g.htm#a_001" STYLE="-sec-extract: exhibit">A:</A></TD><TD STYLE="text-align: justify"><A HREF="https://www.sec.gov/Archives/edgar/data/907654/000110465924054266/tm2412836d2_sc13g.htm#a_001" STYLE="-sec-extract: exhibit">Joint
                                            Filing Agreement (incorporated by reference to Exhibit&nbsp;A to Schedule 13G filed on April&nbsp;29,
                                            2024)</A></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in"><A HREF="https://www.sec.gov/Archives/edgar/data/907654/000110465924054266/tm2412836d2_sc13g.htm#a_002" STYLE="-sec-extract: exhibit">B:</A></TD><TD STYLE="text-align: justify"><A HREF="https://www.sec.gov/Archives/edgar/data/907654/000110465924054266/tm2412836d2_sc13g.htm#a_002" STYLE="-sec-extract: exhibit">Power
                                            of Attorney for Nimish Shah (incorporated by reference to Exhibit&nbsp;B to Schedule 13G
                                            filed April&nbsp;29, 2024)</A></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in"><A HREF="https://www.sec.gov/Archives/edgar/data/907654/000110465924054266/tm2412836d2_sc13g.htm#a_003" STYLE="-sec-extract: exhibit">C:</A></TD><TD STYLE="text-align: justify"><A HREF="https://www.sec.gov/Archives/edgar/data/907654/000110465924054266/tm2412836d2_sc13g.htm#a_003" STYLE="-sec-extract: exhibit">Power
                                            of Attorney for Bong Koh (incorporated by reference to Exhibit&nbsp;C to Schedule 13G filed
                                            on April&nbsp;29, 2024)</A></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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