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Commitments and Contingencies (Details)
€ in Millions
1 Months Ended 3 Months Ended 12 Months Ended
Nov. 30, 2023
Oct. 31, 2023
Aug. 29, 2020
ft²
Jul. 31, 2021
EUR (€)
Jun. 30, 2021
ft²
Mar. 31, 2024
USD ($)
Mar. 31, 2023
USD ($)
Dec. 31, 2023
USD ($)
Dec. 31, 2022
USD ($)
Apr. 30, 2024
USD ($)
Commitments and Contingencies (Details) [Line Items]                    
Amount of retention bonuses           $ 311,000   $ 311,000    
Percentage of retention bonuses 50.00%                  
Retention bonus paid               86,000    
Severance expense               159,000    
Remains unpaid                  
Workforce reduction percentage                 67.00%  
Number of employees                 12  
Square feet (in Square Feet) | ft²     5,200              
Lease term     42 months              
Lease renewal option     option to renew for an additional 36 month term at the then prevailing rental rate.     to extend the lease term six (6) months through September 2024        
Term     36 months     6 months        
Square feet office facilities (in Square Feet) | ft²         3,000          
Sublease term   29 months     29 months          
Lessee operating lease description           The leases include real estate taxes and insurance, which is not a lease component and is not included in the lease obligation. In addition, common area maintenance charges are based on actual costs incurred and are a non-lease component that is not included in the lease obligation.   The leases include real estate taxes and insurance, which is not a lease component and is not included in the lease obligation. In addition, common area maintenance charges are based on actual costs incurred and are a non-lease component that is not included in the lease obligation.    
Lease liability           $ 48,000   $ 280,000    
Operating leases           $ 23,000 $ 33,000 $ 127,000 $ 131,000  
Weighted-average discount rate           7.00%   7.00%    
Weighted-average remaining lease term           6 months   3 years 2 months 12 days    
Indicates (true false) whether lessee has option to extend operating lease           false        
Additional operating lease term           September 2024        
Percentage Of Base Rent To Be Paid Monthly           125.00%        
Clinical development decisions                    
Commitments and Contingencies (Details) [Line Items]                    
Amount of retention bonuses                 265,000  
General and Administrative Expense                    
Commitments and Contingencies (Details) [Line Items]                    
Rent expense           $ 22,000 $ 31,000 $ 119,000 125,000  
One-time Termination Benefits                    
Commitments and Contingencies (Details) [Line Items]                    
Restructuring charges                 755,000  
One-time Termination Benefits | Research and development                    
Commitments and Contingencies (Details) [Line Items]                    
Restructuring charges                 470,000  
One-time Termination Benefits | General and Administrative Expense                    
Commitments and Contingencies (Details) [Line Items]                    
Restructuring charges                 $ 285,000  
Subsequent Event                    
Commitments and Contingencies (Details) [Line Items]                    
Amount of retention bonuses                   $ 444,000
University Medical Center Of Johannes Gutenberg University Mainz | Research and development | Patent Assignment Agreement                    
Commitments and Contingencies (Details) [Line Items]                    
Royalty obligations (in Euro) | €       € 1.6