<SEC-DOCUMENT>0001213900-25-096198-index.html : 20251003
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ACCESSION NUMBER:		0001213900-25-096198
CONFORMED SUBMISSION TYPE:	S-3
PUBLIC DOCUMENT COUNT:		19
FILED AS OF DATE:		20251003
DATE AS OF CHANGE:		20251003

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Oruka Therapeutics, Inc.
		CENTRAL INDEX KEY:			0000907654
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				363855489
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-3
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-290718
		FILM NUMBER:		251375076

	BUSINESS ADDRESS:	
		STREET 1:		855 OAK GROVE AVE.
		STREET 2:		SUITE 100
		CITY:			MENLO PARK
		STATE:			CA
		ZIP:			94025
		BUSINESS PHONE:		650-606-7910

	MAIL ADDRESS:	
		STREET 1:		855 OAK GROVE AVE.
		STREET 2:		SUITE 100
		CITY:			MENLO PARK
		STATE:			CA
		ZIP:			94025

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ARCA biopharma, Inc.
		DATE OF NAME CHANGE:	20090128

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	NUVELO INC
		DATE OF NAME CHANGE:	20030203

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	HYSEQ INC
		DATE OF NAME CHANGE:	19970610
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<TYPE>S-3
<SEQUENCE>1
<FILENAME>ea0260073-s3_oruka.htm
<DESCRIPTION>REGISTRATION STATEMENT
<TEXT>
Document 1 - file: ea0260073-s3_oruka.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-1.2
<SEQUENCE>2
<FILENAME>ea026007301ex1-2_oruka.htm
<DESCRIPTION>SALES AGREEMENT BETWEEN ORUKA THERAPEUTICS, INC. AND TD SECURITIES (USA) LLC, DATED OCTOBER 3, 2025
<TEXT>
Document 2 - file: ea026007301ex1-2_oruka.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>3
<FILENAME>ea026007301ex5-1_oruka.htm
<DESCRIPTION>OPINION OF DAVIS POLK & WARDWELL LLP RELATING TO THE BASE PROSPECTUS
<TEXT>
Document 3 - file: ea026007301ex5-1_oruka.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.2
<SEQUENCE>4
<FILENAME>ea026007301ex5-2_oruka.htm
<DESCRIPTION>OPINION OF DAVIS POLK & WARDWELL LLP RELATING TO THE SALES AGREEMENT PROSPECTUS
<TEXT>
Document 4 - file: ea026007301ex5-2_oruka.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>5
<FILENAME>ea026007301ex23-1_oruka.htm
<DESCRIPTION>CONSENT OF PRICEWATERHOUSECOOPERS LLP, INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
<TEXT>
Document 5 - file: ea026007301ex23-1_oruka.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-FILING FEES
<SEQUENCE>6
<FILENAME>ea026007301ex-fee_oruka.htm
<DESCRIPTION>FILING FEE TABLE
<TEXT>
Document 6 - file: ea026007301ex-fee_oruka.htm

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<TYPE>GRAPHIC
<SEQUENCE>7
<FILENAME>image_001.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 7 - file: image_001.jpg

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<TYPE>GRAPHIC
<SEQUENCE>8
<FILENAME>ex5-1_001.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 8 - file: ex5-1_001.jpg

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<TYPE>GRAPHIC
<SEQUENCE>9
<FILENAME>ex5-2_001.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 9 - file: ex5-2_001.jpg

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<FILENAME>R1.htm
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<TEXT>
Document 11 - file: R1.htm

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<SEQUENCE>12
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<TEXT>
Document 12 - file: R2.htm

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<SEQUENCE>13
<FILENAME>R3.htm
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<TEXT>
Document 13 - file: R3.htm

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<SEQUENCE>14
<FILENAME>Show.js
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<TEXT>
Document 14 - file: Show.js

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<TYPE>XML
<SEQUENCE>15
<FILENAME>report.css
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<TEXT>
Document 15 - file: report.css

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<SEQUENCE>17
<FILENAME>FilingSummary.xml
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<TEXT>
Document 17 - file: FilingSummary.html

Document 17 - RAW XML: FilingSummary.xml

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<TYPE>JSON
<SEQUENCE>19
<FILENAME>MetaLinks.json
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
Document 19 - file: MetaLinks.json

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<DOCUMENT>
<TYPE>ZIP
<SEQUENCE>20
<FILENAME>0001213900-25-096198-xbrl.zip
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Document 20 - file: 0001213900-25-096198-xbrl.zip

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Document 21 - RAW XML: ea026007301ex-fee_oruka_htm.xml

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