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CONSOLIDATED STATEMENTS OF CHANGES IN SHAREHOLDERS EQUITY - USD ($) $ in Thousands | Total | IPO | Preferred A Shares | Ordinary Shares | Ordinary Shares IPO | Preferred Shares | Preferred Shares Preferred A Shares | Additional Paid-In Capital | Additional Paid-In Capital IPO | Additional Paid-In Capital Preferred A Shares | Accumulated Deficit
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2014 | $ 3,163 |  |  | $ 6 |  | $ 2 |  | $ 15,739 |  |  | $ (12,584)
Balance, shares at Dec. 31, 2014 |  |  |  | 2,300,959 |  | 867,103 |  |  |  |  |
Issuance of shares, net of issuance costs | 21,255 |  |  |  |  | $ 9 |  | 21,246 |  |  |
Issuance of shares, net of issuance costs, shares |  |  |  |  |  | 3,635,124 |  |  |  |  |
Purchase of IP R&D in consideration, value |  |  | $ 4,103 |  |  |  | $ 2 |  |  | $ 4,101 |
Purchase of IP R&D in consideration, shares |  |  |  |  |  |  | 691,200 |  |  |  |
Share-based compensation | 449 |  |  |  |  |  |  | 449 |  |  |
Net loss | (12,689) |  |  |  |  |  |  |  |  |  | (12,689)
Balance at Dec. 31, 2015 | 16,281 |  |  | $ 6 |  | $ 13 |  | 41,535 |  |  | (25,273)
Balance, shares at Dec. 31, 2015 |  |  |  | 2,300,959 |  | 5,193,427 |  |  |  |  |
Exercise of options into ordinary shares, shares |  |  |  | 4,784 |  |  |  |  |  |  |
Share-based compensation | 1,967 |  |  |  |  |  |  | 1,967 |  |  |
Net loss | (1,941) |  |  |  |  |  |  |  |  |  | (1,941)
Balance at Dec. 31, 2016 | 16,307 |  |  | $ 6 |  | $ 13 |  | 43,502 |  |  | (27,214)
Balance, shares at Dec. 31, 2016 |  |  |  | 2,305,743 |  | 5,193,427 |  |  |  |  |
Issuance of shares, net of issuance costs |  | $ 60,772 |  |  | $ 15 |  |  |  | $ 60,757 |  |
Issuance of shares, net of issuance costs, shares |  |  |  |  | 5,144,378 |  |  |  |  |  |
Exercise of options into ordinary shares, shares |  |  |  | 812,222 |  |  |  |  |  |  |
Exercise of options into ordinary shares, net of 68,416 shares withheld to pay option price | 404 |  |  | $ 2 |  |  |  | 402 |  |  |
Exercise of options into ordinary shares, net of 68,416 shares withheld to pay option price, shares |  |  |  | 743,806 |  |  |  |  |  |  |
Share-based compensation | 6,300 |  |  |  |  |  |  | 6,300 |  |  |
Exercise of warrants into preferred shares | 4,732 |  |  |  |  | $ 1 |  | 4,731 |  |  |
Exercise of warrants into preferred shares, shares |  |  |  |  |  | 364,036 |  |  |  |  |
Exercise of preferred shares into ordinary shares |  |  |  | $ 14 |  | $ (14) |  |  |  |  |
Exercise of preferred shares into ordinary shares, shares |  |  |  | 5,557,463 |  | (5,557,463) |  |  |  |  |
Net loss | (20,000) |  |  |  |  |  |  |  |  |  | (20,000)
Balance at Dec. 31, 2017 | $ 68,515 |  |  | $ 37 |  |  |  | $ 115,692 |  |  | $ (47,214)
Balance, shares at Dec. 31, 2017 |  |  |  | 13,751,390 |  |  |  |  |  |  |

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