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Share Capital - Schedule of Effect of Share-Based Compensation on Statements of Operations (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]      
Share-based compensation $ 6,300 $ 1,967 $ 449
Research and Development Expenses      
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]      
Share-based compensation 3,923 1,167 170
General and Administrative Expenses      
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]      
Share-based compensation $ 2,377 $ 800 $ 279