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Commitments and Contingencies - Additional Information (Detail)
 12 Months Ended
Jun. 15, 2020
USD ($)
Dec. 31, 2020
USD ($)
Target
shares
Dec. 31, 2019
USD ($)
shares
Jul. 08, 2020
shares
Commitments and Contingencies Disclosure [Line Items]        
Outstanding convertible preferred stock converted into common shares | shares     59,883,877 37,206,604
Research and development expense   $ 99,862,000 $ 70,306,000  
Accrued expenses   5,760,000 3,746,000  
DE Shaw Research [Member]        
Commitments and Contingencies Disclosure [Line Items]        
Research and development expense   6,376,000 1,500,000  
Accrued expenses   $ 1,500,000 372,000  
DE Shaw Research [Member] | License Agreement Terms [Member]        
Commitments and Contingencies Disclosure [Line Items]        
Outstanding convertible preferred stock converted into common shares | shares   3,281,253    
Research and development arrangement, annual fee $ 7,900,000   1,000,000  
Research and development arrangement, term of contract   3 years    
Research and development arrangement, expiration date Aug. 16, 2025      
Milestone payment Due   $ 7,250,000    
Maximum additional amount received upon milestone achievement   6,250,000    
DE Shaw Research [Member] | Lease Agreement        
Commitments and Contingencies Disclosure [Line Items]        
Milestone payment Due   1,500,000 0  
Other Third Parties [Member]        
Commitments and Contingencies Disclosure [Line Items]        
Research and development expense   2,704,000 3,493,000  
Other Third Parties [Member] | License Agreement Terms [Member]        
Commitments and Contingencies Disclosure [Line Items]        
Milestone payment Due   $ 0 $ 0  
Number of milestone targets | Target   4    
Maximum [Member] | DE Shaw Research [Member] | License Agreement Terms [Member]        
Commitments and Contingencies Disclosure [Line Items]        
Agreement renewal period   1 year    
Potential development milestone payments   $ 7,300,000    
Maximum [Member] | Other Third Parties [Member] | License Agreement Terms [Member]        
Commitments and Contingencies Disclosure [Line Items]        
Potential development milestone payments   7,000,000    
Minimum [Member] | Other Third Parties [Member] | License Agreement Terms [Member]        
Commitments and Contingencies Disclosure [Line Items]        
Potential development milestone payments   $ 4,000,000    
Series A Preferred Stock [Member]        
Commitments and Contingencies Disclosure [Line Items]        
Outstanding convertible preferred stock converted into common shares | shares     16,002,820  
Series A Preferred Stock [Member] | DE Shaw Research [Member] | License Agreement Terms [Member]        
Commitments and Contingencies Disclosure [Line Items]        
Shares held | shares     9,999,999  
Series C Preferred Stock [Member]        
Commitments and Contingencies Disclosure [Line Items]        
Outstanding convertible preferred stock converted into common shares | shares     35,097,955  
Series C Preferred Stock [Member] | DE Shaw Research [Member] | License Agreement Terms [Member]        
Commitments and Contingencies Disclosure [Line Items]        
Shares held | shares     1,557,875