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Nature of Business and Basis of Presentation - Additional Information (Detail)
$ in Thousands
Jun. 30, 2023
USD ($)
Program
Dec. 31, 2022
USD ($)
Nature Of Business And Basis Of Presentation [Line Items]    
Accumulated deficit | $ $ (1,251,353) $ (1,058,609)
HR+/HER2- Breast Cancer [Member]    
Nature Of Business And Basis Of Presentation [Line Items]    
Number of discovery stage programs 2  
Precision Oncology and Genetic Disease Indications [Member]    
Nature Of Business And Basis Of Presentation [Line Items]    
Number of discovery stage programs 5