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Fair Value Measurements - Summary of Financial Assets and Liabilities Measured at Fair Value on a Recurring Basis and Level of the Fair Value Hierarchy (Detail) - Fair value on a recurring basis [Member] - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022
Investments:
Total assets	$ 849,586	$ 975,519
Liabilities
Contingent Milestone Payments	24,223	27,378
Total liabilities	24,223	27,378
Investments [Member]
Investments:
Total investments	725,671	847,123
Investments [Member] | U.S treasury bills [Member]
Investments:
Total investments	378,391	466,603
Investments [Member] | U.S agency securities [Member]
Investments:
Total investments	347,280	380,520
Cash equivalents [Member]
Cash equivalents:
Assets, fair value	123,915	128,396
Cash equivalents [Member] | Money market funds [Member]
Cash equivalents:
Assets, fair value	113,936	118,446
Cash equivalents [Member] | U.S treasury bills [Member]
Cash equivalents:
Assets, fair value	9,979	9,950
Level 1 [Member]
Investments:
Total assets	113,936	118,446
Level 1 [Member] | Cash equivalents [Member]
Cash equivalents:
Assets, fair value	113,936	118,446
Level 1 [Member] | Cash equivalents [Member] | Money market funds [Member]
Cash equivalents:
Assets, fair value	113,936	118,446
Level 2 [Member]
Investments:
Total assets	735,650	857,073
Level 2 [Member] | Investments [Member]
Investments:
Total investments	725,671	847,123
Level 2 [Member] | Investments [Member] | U.S treasury bills [Member]
Investments:
Total investments	378,391	466,603
Level 2 [Member] | Investments [Member] | U.S agency securities [Member]
Investments:
Total investments	347,280	380,520
Level 2 [Member] | Cash equivalents [Member]
Cash equivalents:
Assets, fair value	9,979	9,950
Level 2 [Member] | Cash equivalents [Member] | U.S treasury bills [Member]
Cash equivalents:
Assets, fair value	9,979	9,950
Level 3 [Member]
Liabilities
Contingent Milestone Payments	24,223	27,378
Total liabilities	$ 24,223	$ 27,378

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Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Name Accounting Standards Codification
-Topic 820
-SubTopic 10
-Section 50
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