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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 3 Months Ended 6 Months Ended 12 Months Ended
Jun. 30, 2021
Jun. 30, 2020
Jun. 30, 2021
Jun. 30, 2020
Jun. 30, 2021
Dec. 31, 2020
Operating activities:            
Net loss $ (9,794) $ (7,384) $ (18,165) $ (15,857)   $ (32,800)
Adjustments to reconcile net loss to net cash used in operating activities:            
Depreciation     25 21    
Change in fair value of term loan derivative liability     (34)      
Accretion/accrual of term loan discounts and debt issuance costs     291      
Other expense related to transaction with Lincoln Park Capital Fund, LLC     375      
Stock-based compensation 745 589 1,463 1,319    
Changes in operating assets and liabilities:            
Prepaid expenses and other current assets     (592) 76    
Accounts payable     1,471 1,561    
Accrued expenses and other liabilities     (310) (229)    
Net cash used in operating activities     (15,476) (13,109)    
Investing activities:            
Purchases of property, equipment and leasehold improvements       (12)    
Net cash used in investing activities       (12)    
Financing activities:            
Proceeds from at-the-market sales, net of commissions     6,972      
Proceeds from exercises of stock options       27    
Proceeds from employee stock purchase plan     17 3    
Payments of offering costs     (89) (42)    
Net cash provided by (used in) financing activities     6,900 (12)    
Net decrease in cash and cash equivalents     (8,576) (13,133)    
Cash and cash equivalents at beginning of period     45,001 57,313 $ 44,180 57,313
Cash and cash equivalents at end of period $ 36,425 $ 44,180 $ 36,425 $ 44,180 $ 36,425 $ 45,001