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Stockholders' Equity (Tables) | 6 Months Ended
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Jun. 30, 2022
Stockholders Equity Note [Abstract] |
Schedule of Common Stock Reserved for Future Issuance | As of June 30, 2022 and December 31, 2021, the Company had reserved shares of common stock for future issuance as shown in the table below:
|  | June 30, 2022 |  |  | December 31, 2021 |
Shares of common stock reserved for future issuance under the 2012 Stock Incentive Plan |  |  | 663,089 |  |  |  | 665,720 |
Shares of common stock reserved for future issuance under the 2019 Stock Incentive Plan |  |  | 4,543,352 |  |  |  | 3,400,489 |
Shares of common stock reserved for future issuance under the 2019 Employee Stock Purchase Plan |  |  | 721,717 |  |  |  | 470,631 |
Shares to be issued upon exercise of common stock warrants and pre-funded warrants |  |  | 38,382,647 |  |  |  | 20,602,244 |
Shares to be issued upon sales under the LPC Purchase Agreement |  |  | 30,000,000 |  |  |  | 30,000,000 |
|  |  | 74,310,805 |  |  |  | 55,139,084 |
Warrant Activity Including Activity Related To Pre-funded Warrants | Warrant activity, including activity related to the pre-funded warrants, for the six months ended June 30, 2022 is shown in the table below:
|  | Number of Pre-funded Warrant Shares |  |  | Number of Common Stock Warrant Shares |  |  | Total Number of Warrant Shares |  |  | Weighted Average Exercise Price |
Outstanding as of December 31, 2021 |  |  | 2,300,000 |  |  |  | 18,302,244 |  |  |  | 20,602,244 |  |  | $ | 1.22 |
Issued |  |  | 24,379,673 |  |  |  | — |  |  |  | 24,379,673 |  |  | $ | 0.001 |
Exercised |  |  | (2,300,000 | ) |  |  | (4,299,270 | ) |  |  | (6,599,270 | ) |  | $ | 1.37 |
Outstanding as of June 30, 2022 |  |  | 24,379,673 |  |  |  | 14,002,974 |  |  |  | 38,382,647 |  |  | $ | 0.50 |
Schedule of Share-based Compensation, Stock Options, Activity | A summary of the Company’s combined stock option activity for the 2019 Plan and the 2012 Plan for the six months ended June 30, 2022 is as follows:
|  | Number of Option Shares |  |  | Weighted Average Exercise Price |
Outstanding as of December 31, 2021 |  |  | 2,929,472 |  |  | $ | 4.51 |
Granted |  |  | 1,258,750 |  |  | $ | 0.68 |
Forfeited |  |  | (41,224 | ) |  | $ | 4.21 |
Expired |  |  | (2,631 | ) |  | $ | 1.43 |
Exercised |  |  | — |  |  | $ | — |
Outstanding as of June 30, 2022 |  |  | 4,144,367 |  |  | $ | 3.35 |
Options exercisable as of June 30, 2022 |  |  | 2,005,863 |  |  | $ | 4.70 |
Options unvested as of June 30, 2022 |  |  | 2,138,504 |  |  | $ | 2.09 |
Schedule of Stock-based Compensation Expenses Recognized | The following table summarizes the classifications of stock-based compensation expenses for the 2012 Plan, the 2019 Plan and the 2019 ESPP recognized in the Condensed Consolidated Statements of Comprehensive Loss:
|  | Three Months Ended June 30, |  |  | Six Months Ended June 30, |
|  | 2022 |  |  | 2021 |  |  | 2022 |  |  | 2021 |
General and administrative expense |  | $ | 348 |  |  | $ | 494 |  |  | $ | 825 |  |  | $ | 1,039 |
Research and development expense |  |  | 172 |  |  |  | 251 |  |  |  | 432 |  |  |  | 424 |
|  | $ | 520 |  |  | $ | 745 |  |  | $ | 1,257 |  |  | $ | 1,463 |

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