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Stockholders' Equity (Tables)

6 Months Ended

Jun. 30, 2022

Schedule of Common Stock Reserved for Future Issuance

As of June 30, 2022 and December 31, 2021, the Company had reserved shares of common stock for future issuance as shown in the table below:

	June 30, 2022		December 31, 2021
Shares of common stock reserved for future issuance under the 2012 Stock Incentive Plan		663,089		665,720
Shares of common stock reserved for future issuance under the 2019 Stock Incentive Plan		4,543,352		3,400,489
Shares of common stock reserved for future issuance under the 2019 Employee Stock Purchase Plan		721,717		470,631
Shares to be issued upon exercise of common stock warrants and pre-funded warrants		38,382,647		20,602,244
Shares to be issued upon sales under the LPC Purchase Agreement		30,000,000		30,000,000
		74,310,805		55,139,084

Warrant Activity Including Activity Related To Pre-funded Warrants

Warrant activity, including activity related to the pre-funded warrants, for the six months ended June 30, 2022 is shown in the table below:

	Number of Pre-funded Warrant Shares			Number of Common Stock Warrant Shares			Total Number of Warrant Shares			Weighted Average Exercise Price
Outstanding as of December 31, 2021		2,300,000			18,302,244			20,602,244		$	1.22
Issued		24,379,673			—			24,379,673		$	0.001
Exercised		(2,300,000	)		(4,299,270	)		(6,599,270	)	$	1.37
Outstanding as of June 30, 2022		24,379,673			14,002,974			38,382,647		$	0.50

Schedule of Share-based Compensation, Stock Options, Activity

A summary of the Company’s combined stock option activity for the 2019 Plan and the 2012 Plan for the six months ended June 30, 2022 is as follows:

	Number of Option Shares			Weighted Average Exercise Price
Outstanding as of December 31, 2021		2,929,472		$	4.51
Granted		1,258,750		$	0.68
Forfeited		(41,224	)	$	4.21
Expired		(2,631	)	$	1.43
Exercised		—		$	—
Outstanding as of June 30, 2022		4,144,367		$	3.35
Options exercisable as of June 30, 2022		2,005,863		$	4.70
Options unvested as of June 30, 2022		2,138,504		$	2.09

Schedule of Stock-based Compensation Expenses Recognized

The following table summarizes the classifications of stock-based compensation expenses for the 2012 Plan, the 2019 Plan and the 2019 ESPP recognized in the Condensed Consolidated Statements of Comprehensive Loss:

	Three Months Ended June 30,				Six Months Ended June 30,
	2022		2021		2022		2021
General and administrative expense	$	348	$	494	$	825	$	1,039
Research and development expense		172		251		432		424
	$	520	$	745	$	1,257	$	1,463