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Debt - Additional Information (Detail) $ in Thousands				1 Months Ended	3 Months Ended		5 Months Ended	6 Months Ended
Debt - Additional Information (Detail) $ in Thousands	Apr. 06, 2022 USD ($)	Jul. 06, 2021 USD ($)	Aug. 13, 2020 USD ($) Installment	Oct. 31, 2021 PrivatePlacement	Jun. 30, 2022 USD ($)	Jun. 30, 2021 USD ($)	Oct. 31, 2021 USD ($)	Jun. 30, 2022 USD ($)	Jun. 30, 2021 USD ($)	Dec. 31, 2021 USD ($)	Aug. 31, 2020 USD ($)
Private Placement [Member]
Number of private placements \| PrivatePlacement				2
SVB Term Loan [Member]
Debt instrument, principal amount			$ 14,000		$ 11,667			$ 11,667		$ 14,000
Interest-only payment period			24 months
Loan payment, number of consecutive equal monthly installments of principal including accrued interest \| Installment			24
Debt instrument, maturity date								Feb. 01, 2024
Debt instrument, final payment fee amount			$ 1,200		1,200			$ 1,200
Debt default additional interest charge			5.00%
Debt finance costs		$ 68									$ 57
Amortization of deferred financing charges					20	$ 5		37	$ 11
Unamortized deferred charges					60			60		76
Financing costs paid											$ 27
Accretion loan discounts					2	2		5	5
Loan discounts-financing costs					7			7		12
Accrual of the final payment fee					104	119		220	237
Debt instrument, accrued final payment fee					877			$ 877		657
Contingent interest rate increase								2.00%
Amortization of term loan					16	$ 19		$ 35	$ 37
Term loan discount interest					$ 49			$ 49		$ 84
Weighted average interest rate, floating					4.92%	4.25%		4.59%	4.25%
SVB Term Loan [Member] \| Term Loan Derivative Liability [Member]
Term loan derivative liability			$ 187
SVB Term Loan [Member] \| Term Loan Derivative Liability [Member] \| Contingent Interest Rate Increase [Member]
Derivative liability, measurement input					0.0200			0.0200
SVB Term Loan [Member] \| Term Loan Derivative Liability [Member] \| Discount Rate [Member]
Derivative liability, measurement input					0.120			0.120
SVB Term Loan [Member] \| Minimum [Member]
Interest rate, floating			4.25%
Long term debt percentage bearing adjusted floating interest rate			6.25%
SVB Term Loan [Member] \| First Amendment
Debt instruments percentage of required to deposit unrestricted and unencumbered cash collateral		100.00%
Equity raise requirements, description								if the Company failed to receive positive data in its Phase 2b/3 PRISM trial or to raise by June 30, 2022 sufficient net proceeds from the sale of equity securities to finance its planned second Phase 3 clinical trial of Haduvio for prurigo nodularis and its ongoing operations (each a “Milestone Condition”), the Company would be required to deposit unrestricted and unencumbered cash equal to 100% of all outstanding amounts owed to SVB in a cash collateral account with SVB, which could be used by SVB to prepay the SVB Term Loan at any time.
SVB Term Loan [Member] \| First Amendment \| Minimum [Member]
Proceeds from the sale of equity securities							$ 15,000
Debt instruments amount of required to maintain unrestricted and unencumbered cash		$ 20,000
SVB Term Loan [Member] \| Third Amendment [Member]
Proceeds from the sale of equity securities	$ 45,000
Debt finance costs					$ 21			$ 21
SVB Term Loan [Member] \| Third Amendment [Member] \| Term Loan Derivative Liability [Member]
Term loan derivative liability					$ 136			$ 136
SVB Term Loan [Member] \| Third Amendment [Member] \| Minimum [Member]
Interest rate, floating	4.25%
Long term debt percentage bearing adjusted floating interest rate	6.25%
SVB Term Loan [Member] \| Prepayment Prior to First Anniversary of Effective Date [Member]
Prepayment premium percentage on principal amount			3.00%
SVB Term Loan [Member] \| Prepayment After First Anniversary of Effective Date and Prior To Second Anniversary of Effective Date [Member]
Prepayment premium percentage on principal amount			2.00%
SVB Term Loan [Member] \| Prepayment After Second Anniversary of the Effective Date and Prior to February 1, 2024 [Member]
Prepayment premium percentage on principal amount			1.00%
SVB Term Loan [Member] \| Prime Rate [Member]
Variable interest rate			1.00%
SVB Term Loan [Member] \| Prime Rate [Member] \| Third Amendment [Member]
Variable interest rate	1.00%
SVB Term Loan [Member] \| Adjusted Prime Rate [Member]
Variable interest rate			3.00%
SVB Term Loan [Member] \| Adjusted Prime Rate [Member] \| Third Amendment [Member]
Variable interest rate	3.00%