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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 6 Months Ended
Jun. 30, 2022
Jun. 30, 2021
Operating activities:    
Net loss $ (15,381) $ (18,165)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation 19 25
Accretion of available-for-sale marketable securities, net (72)  
Change in fair value of term loan derivative liability 147 (34)
Accretion/accrual of term loan discounts and debt issuance costs 297 291
Other expense related to transaction with Lincoln Park Capital Fund, LLC   375
Stock-based compensation 1,257 1,463
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets (885) (592)
Accounts payable 941 1,471
Accrued expenses and other liabilities 409 (310)
Net cash used in operating activities (13,268) (15,476)
Investing activities:    
Purchases of available-for-sale marketable securities (54,217)  
Net cash used in investing activities (54,217)  
Financing activities:    
Repayments of term loan (2,333)  
Payments of financing costs of term loan (21)  
Proceeds from sale of common stock and warrants under private placement, net of issuance costs 51,826  
Proceeds from exercises of warrants 5,892  
Proceeds from employee stock purchase plan 23 17
Proceeds from at-the-market sales, net of commissions   6,972
Payments of offering costs (34) (89)
Net cash provided by financing activities 55,353 6,900
Net decrease in cash and cash equivalents (12,132) (8,576)
Cash and cash equivalents at beginning of period 36,830 45,001
Cash and cash equivalents at end of period $ 24,698 $ 36,425