<SEC-DOCUMENT>0001972481-25-000242.txt : 20251007
<SEC-HEADER>0001972481-25-000242.hdr.sgml : 20251007
<ACCEPTANCE-DATETIME>20251007162641
ACCESSION NUMBER:		0001972481-25-000242
CONFORMED SUBMISSION TYPE:	144
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20251007
DATE AS OF CHANGE:		20251007

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Trevi Therapeutics, Inc.
		CENTRAL INDEX KEY:			0001563880
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				450834299
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		144
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	001-38886
		FILM NUMBER:		251380143

	BUSINESS ADDRESS:	
		STREET 1:		195 CHURCH STREET
		STREET 2:		16TH FLOOR
		CITY:			NEW HAVEN
		STATE:			CT
		ZIP:			06510
		BUSINESS PHONE:		203-304-2499

	MAIL ADDRESS:	
		STREET 1:		195 CHURCH STREET
		STREET 2:		16TH FLOOR
		CITY:			NEW HAVEN
		STATE:			CT
		ZIP:			06510

REPORTING-OWNER:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Delfini Lisa
		CENTRAL INDEX KEY:			0001873253
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		144

	MAIL ADDRESS:	
		STREET 1:		C/O TREVI THERAPEUTICS, INC.
		STREET 2:		195 CHURCH STREET, FL. 16
		CITY:			NEW HAVEN
		STATE:			CT
		ZIP:			06510
</SEC-HEADER>
<DOCUMENT>
<TYPE>144
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
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      <filer>
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          <cik>0001873253</cik>
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      <issuerCik>0001563880</issuerCik>
      <issuerName>Trevi Therapeutics, Inc.</issuerName>
      <secFileNumber>001-38886</secFileNumber>
      <issuerAddress>
        <com:street1>195 CHURCH STREET</com:street1>
        <com:street2>16TH FLOOR</com:street2>
        <com:city>NEW HAVEN</com:city>
        <com:stateOrCountry>CT</com:stateOrCountry>
        <com:zipCode>06510</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>203-304-2499</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Delfini Lisa</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Stifel Nicolaus &amp; Company Inc</name>
        <address>
          <com:street1>501 N Broadway</com:street1>
          <com:city>St. Louis</com:city>
          <com:stateOrCountry>MO</com:stateOrCountry>
          <com:zipCode>63102</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>108650</noOfUnitsSold>
      <aggregateMarketValue>1032175.00</aggregateMarketValue>
      <noOfUnitsOutstanding>121776855</noOfUnitsOutstanding>
      <approxSaleDate>10/07/2025</approxSaleDate>
      <securitiesExchangeName>Nasdaq</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>02/26/2023</acquiredDate>
      <natureOfAcquisitionTransaction>Option Exercise</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>312855</amountOfSecuritiesAcquired>
      <paymentDate>02/16/2023</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Lisa Delfini</name>
        <address>
          <com:street1>195 Church Street 16th Floor</com:street1>
          <com:city>New Haven</com:city>
          <com:stateOrCountry>CT</com:stateOrCountry>
          <com:zipCode>06510</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>10/06/2025</saleDate>
      <amountOfSecuritiesSold>8650</amountOfSecuritiesSold>
      <grossProceeds>86817.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Lisa Delfini</name>
        <address>
          <com:street1>195 Church Street 16th Floor</com:street1>
          <com:city>New Haven</com:city>
          <com:stateOrCountry>CT</com:stateOrCountry>
          <com:zipCode>06510</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>10/03/2025</saleDate>
      <amountOfSecuritiesSold>20000</amountOfSecuritiesSold>
      <grossProceeds>193358.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
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          <com:zipCode>06510</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>08/27/2025</saleDate>
      <amountOfSecuritiesSold>10000</amountOfSecuritiesSold>
      <grossProceeds>80949.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Lisa Delfini</name>
        <address>
          <com:street1>195 Church Street 16th Floor</com:street1>
          <com:city>New Haven</com:city>
          <com:stateOrCountry>CT</com:stateOrCountry>
          <com:zipCode>06510</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>08/28/2025</saleDate>
      <amountOfSecuritiesSold>1500</amountOfSecuritiesSold>
      <grossProceeds>12330.00</grossProceeds>
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    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Lisa Delfini</name>
        <address>
          <com:street1>195 Church Street 16th Floor</com:street1>
          <com:city>New Haven</com:city>
          <com:stateOrCountry>CT</com:stateOrCountry>
          <com:zipCode>06510</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>09/08/2025</saleDate>
      <amountOfSecuritiesSold>41779</amountOfSecuritiesSold>
      <grossProceeds>322751.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Lisa Delfini</name>
        <address>
          <com:street1>195 Church Street 16th Floor</com:street1>
          <com:city>New Haven</com:city>
          <com:stateOrCountry>CT</com:stateOrCountry>
          <com:zipCode>06510</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>09/09/2025</saleDate>
      <amountOfSecuritiesSold>155000</amountOfSecuritiesSold>
      <grossProceeds>1256787.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Lisa Delfini</name>
        <address>
          <com:street1>195 Church Street 16th Floor</com:street1>
          <com:city>New Haven</com:city>
          <com:stateOrCountry>CT</com:stateOrCountry>
          <com:zipCode>06510</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>09/23/2025</saleDate>
      <amountOfSecuritiesSold>8600</amountOfSecuritiesSold>
      <grossProceeds>73220.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Lisa Delfini</name>
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          <com:stateOrCountry>CT</com:stateOrCountry>
          <com:zipCode>06510</com:zipCode>
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      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>09/24/2025</saleDate>
      <amountOfSecuritiesSold>4836</amountOfSecuritiesSold>
      <grossProceeds>41146.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Lisa Delfini</name>
        <address>
          <com:street1>195 Church Street 16th Floor</com:street1>
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          <com:stateOrCountry>CT</com:stateOrCountry>
          <com:zipCode>06510</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>09/25/2025</saleDate>
      <amountOfSecuritiesSold>26073</amountOfSecuritiesSold>
      <grossProceeds>224137.00</grossProceeds>
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    <securitiesSoldInPast3Months>
      <sellerDetails>
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      <securitiesClassTitle>Common Stock</securitiesClassTitle>
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      <amountOfSecuritiesSold>65067</amountOfSecuritiesSold>
      <grossProceeds>571529.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>10/07/2025</noticeDate>
      <signature>/s/ Luca Lotito, as a duly authorized representative of STIFEL, as attorney-in-fact for Lisa Delfini</signature>
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