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Pay vs Performance Disclosure - USD ($)
 12 Months Ended
Dec. 31, 2025
Dec. 31, 2024
Dec. 31, 2023
Pay vs Performance Disclosure      
Pay vs Performance Disclosure, Table

Pay Versus Performance Table

The following table provides the information required for our NEOs for each of the fiscal years ended December 31, 2025, December 31, 2024, and December 31, 2023 along with the financial information required for each fiscal year. As a pre-commercial biotechnology company, we do not use Net Income (Loss) performance in determining our executive compensation, and as a smaller reporting company, we are not required to choose a “Company Selected Measure.” Information presented in this section will not be deemed to be incorporated by reference into any of our filings under the Securities Act of 1933, as amended, or the Exchange Act, except as we may specifically do so by reference to this section.

 

Year

 

Summary Compensation Table Total for PEO (1) ($)

 

 

Compensation Actually Paid to PEO (2) ($)

 

 

Average Summary Compensation Table Total for non-PEO NEOs ($)

 

 

Average Compensation Actually Paid to non-PEO NEOs (2) ($)

 

 

Value of Initial Fixed $100 Investment Based on Total Shareholder Return (3) ($)

 

 

Net Income (Loss) ($M)

 

2025

 

 

3,944,892

 

 

 

15,377,546

 

 

 

1,496,559

 

 

 

5,419,549

 

 

 

648.70

 

 

 

(42.76

)

2024

 

 

2,589,035

 

 

 

4,954,025

 

 

 

1,314,261

 

 

 

2,021,363

 

 

 

213.47

 

 

 

(47.91

)

2023

 

 

1,687,298

 

 

 

1,107,264

 

 

 

793,882

 

 

 

567,277

 

 

 

69.43

 

 

 

(29.07

)

(1) Ms. Jennifer Good served as our PEO for the fiscal years ended December 31, 2023, December 31, 2024 and December 31, 2025. Our non-PEO NEOs for the fiscal year ended December 31, 2023 were Dr. David Clark, our former Chief Medical Officer, and Dr. Thomas Sciascia, our Chief Scientific Officer. Our non-PEO NEOs for the fiscal year ended December 31, 2024 were Dr. James Cassella, our Chief Development Officer, and Ms. Lisa Delfini, our former Chief Financial Officer. Our non-PEO NEOs for the fiscal year ended December 31, 2025 were Dr. James Cassella, our Chief Development Officer, and Dr. Farrell Simon, our Chief Commercial Officer.

(2) Deductions from, and additions to, total compensation in the Summary Compensation Table by year to calculate compensation actually paid, or CAP, include:

 

 

2025

 

 

2024

 

 

2023

 

 

PEO ($)

 

 

Average non-PEO NEOs ($)

 

 

PEO ($)

 

 

Average non-PEO NEOs ($)

 

 

PEO ($)

 

 

Average non-PEO NEOs ($)

 

Total Compensation from Summary Compensation Table

 

3,944,892

 

 

 

1,496,559

 

 

 

2,589,035

 

 

 

1,314,261

 

 

 

1,687,298

 

 

 

793,882

 

- Grant Date Fair Value of Option Awards and Stock Awards Granted in Fiscal Year

 

(2,968,260

)

 

 

(883,890

)

 

 

(1,601,781

)

 

 

(872,216

)

 

 

(851,399

)

 

 

(212,850

)

+ Fair Value at Fiscal Year-End of Outstanding and Unvested Option Awards and Stock Awards Granted in Fiscal Year

 

8,944,352

 

 

 

2,663,454

 

 

 

2,825,276

 

 

 

1,272,035

 

 

 

341,324

 

 

 

85,331

 

+ Change in Fair Value of Outstanding and Unvested Option Awards and Stock Awards Granted in Prior Fiscal Years

 

3,588,846

 

 

 

1,549,727

 

 

 

744,655

 

 

 

192,013

 

 

 

(120,418

)

 

 

(87,704

)

+ Fair Value at Vesting of Option Awards and Stock Awards Granted in Fiscal Year That Vested During Fiscal Year

 

—

 

 

 

—

 

 

 

—

 

 

 

—

 

 

 

—

 

 

 

—

 

+ Change in Fair Value as of Vesting Date of Option Awards and Stock Awards Granted in Prior Fiscal Years For Which Applicable Vesting Conditions Were Satisfied During Fiscal Year

 

1,867,716

 

 

 

593,699

 

 

 

396,839

 

 

 

115,270

 

 

 

50,458

 

 

 

(11,382

)

- Fair Value as of Prior Fiscal Year-End of Option Awards and Stock Awards Granted in Prior Fiscal Years That Failed to Meet Applicable Vesting Conditions During Fiscal Year

 

—

 

 

 

—

 

 

 

—

 

 

 

—

 

 

 

—

 

 

 

—

 

Compensation Actually Paid

 

15,377,546

 

 

 

5,419,549

 

 

 

4,954,025

 

 

 

2,021,363

 

 

 

1,107,264

 

 

 

567,277

 

(3) Total Shareholder Return illustrates the value, as of the last day of the indicated fiscal year, of an investment of $100 in our common stock made after the market closed on December 31, 2022.

Analysis of the Information Presented in the Pay Versus Performance Table

The illustrations below provide a graphical description of CAP (as calculated in accordance with the SEC rules) for each of the last three completed fiscal years and the following measures:

•
Trevi’s cumulative total shareholder return, or TSR; and
•
Trevi’s Net Income (Loss).
    
Named Executive Officers, Footnote

(1) Ms. Jennifer Good served as our PEO for the fiscal years ended December 31, 2023, December 31, 2024 and December 31, 2025. Our non-PEO NEOs for the fiscal year ended December 31, 2023 were Dr. David Clark, our former Chief Medical Officer, and Dr. Thomas Sciascia, our Chief Scientific Officer. Our non-PEO NEOs for the fiscal year ended December 31, 2024 were Dr. James Cassella, our Chief Development Officer, and Ms. Lisa Delfini, our former Chief Financial Officer. Our non-PEO NEOs for the fiscal year ended December 31, 2025 were Dr. James Cassella, our Chief Development Officer, and Dr. Farrell Simon, our Chief Commercial Officer.

    
PEO Total Compensation Amount $ 3,944,892 $ 2,589,035 $ 1,687,298
PEO Actually Paid Compensation Amount $ 15,377,546 4,954,025 1,107,264
Adjustment To PEO Compensation, Footnote

(2) Deductions from, and additions to, total compensation in the Summary Compensation Table by year to calculate compensation actually paid, or CAP, include:

 

 

2025

 

 

2024

 

 

2023

 

 

PEO ($)

 

 

Average non-PEO NEOs ($)

 

 

PEO ($)

 

 

Average non-PEO NEOs ($)

 

 

PEO ($)

 

 

Average non-PEO NEOs ($)

 

Total Compensation from Summary Compensation Table

 

3,944,892

 

 

 

1,496,559

 

 

 

2,589,035

 

 

 

1,314,261

 

 

 

1,687,298

 

 

 

793,882

 

- Grant Date Fair Value of Option Awards and Stock Awards Granted in Fiscal Year

 

(2,968,260

)

 

 

(883,890

)

 

 

(1,601,781

)

 

 

(872,216

)

 

 

(851,399

)

 

 

(212,850

)

+ Fair Value at Fiscal Year-End of Outstanding and Unvested Option Awards and Stock Awards Granted in Fiscal Year

 

8,944,352

 

 

 

2,663,454

 

 

 

2,825,276

 

 

 

1,272,035

 

 

 

341,324

 

 

 

85,331

 

+ Change in Fair Value of Outstanding and Unvested Option Awards and Stock Awards Granted in Prior Fiscal Years

 

3,588,846

 

 

 

1,549,727

 

 

 

744,655

 

 

 

192,013

 

 

 

(120,418

)

 

 

(87,704

)

+ Fair Value at Vesting of Option Awards and Stock Awards Granted in Fiscal Year That Vested During Fiscal Year

 

—

 

 

 

—

 

 

 

—

 

 

 

—

 

 

 

—

 

 

 

—

 

+ Change in Fair Value as of Vesting Date of Option Awards and Stock Awards Granted in Prior Fiscal Years For Which Applicable Vesting Conditions Were Satisfied During Fiscal Year

 

1,867,716

 

 

 

593,699

 

 

 

396,839

 

 

 

115,270

 

 

 

50,458

 

 

 

(11,382

)

- Fair Value as of Prior Fiscal Year-End of Option Awards and Stock Awards Granted in Prior Fiscal Years That Failed to Meet Applicable Vesting Conditions During Fiscal Year

 

—

 

 

 

—

 

 

 

—

 

 

 

—

 

 

 

—

 

 

 

—

 

Compensation Actually Paid

 

15,377,546

 

 

 

5,419,549

 

 

 

4,954,025

 

 

 

2,021,363

 

 

 

1,107,264

 

 

 

567,277

 
   
Non-PEO NEO Average Total Compensation Amount $ 1,496,559 1,314,261 793,882
Non-PEO NEO Average Compensation Actually Paid Amount $ 5,419,549 2,021,363 567,277
Adjustment to Non-PEO NEO Compensation Footnote

(2) Deductions from, and additions to, total compensation in the Summary Compensation Table by year to calculate compensation actually paid, or CAP, include:

 

 

2025

 

 

2024

 

 

2023

 

 

PEO ($)

 

 

Average non-PEO NEOs ($)

 

 

PEO ($)

 

 

Average non-PEO NEOs ($)

 

 

PEO ($)

 

 

Average non-PEO NEOs ($)

 

Total Compensation from Summary Compensation Table

 

3,944,892

 

 

 

1,496,559

 

 

 

2,589,035

 

 

 

1,314,261

 

 

 

1,687,298

 

 

 

793,882

 

- Grant Date Fair Value of Option Awards and Stock Awards Granted in Fiscal Year

 

(2,968,260

)

 

 

(883,890

)

 

 

(1,601,781

)

 

 

(872,216

)

 

 

(851,399

)

 

 

(212,850

)

+ Fair Value at Fiscal Year-End of Outstanding and Unvested Option Awards and Stock Awards Granted in Fiscal Year

 

8,944,352

 

 

 

2,663,454

 

 

 

2,825,276

 

 

 

1,272,035

 

 

 

341,324

 

 

 

85,331

 

+ Change in Fair Value of Outstanding and Unvested Option Awards and Stock Awards Granted in Prior Fiscal Years

 

3,588,846

 

 

 

1,549,727

 

 

 

744,655

 

 

 

192,013

 

 

 

(120,418

)

 

 

(87,704

)

+ Fair Value at Vesting of Option Awards and Stock Awards Granted in Fiscal Year That Vested During Fiscal Year

 

—

 

 

 

—

 

 

 

—

 

 

 

—

 

 

 

—

 

 

 

—

 

+ Change in Fair Value as of Vesting Date of Option Awards and Stock Awards Granted in Prior Fiscal Years For Which Applicable Vesting Conditions Were Satisfied During Fiscal Year

 

1,867,716

 

 

 

593,699

 

 

 

396,839

 

 

 

115,270

 

 

 

50,458

 

 

 

(11,382

)

- Fair Value as of Prior Fiscal Year-End of Option Awards and Stock Awards Granted in Prior Fiscal Years That Failed to Meet Applicable Vesting Conditions During Fiscal Year

 

—

 

 

 

—

 

 

 

—

 

 

 

—

 

 

 

—

 

 

 

—

 

Compensation Actually Paid

 

15,377,546

 

 

 

5,419,549

 

 

 

4,954,025

 

 

 

2,021,363

 

 

 

1,107,264

 

 

 

567,277

 
   
Compensation Actually Paid vs. Total Shareholder Return

Compensation Actually Paid versus Total Shareholder Return

img92490068_3.gif

    
Compensation Actually Paid vs. Net Income

Compensation Actually Paid versus Net Income (Loss)

img92490068_4.gif

    
Tabular List, Table

The illustrations below provide a graphical description of CAP (as calculated in accordance with the SEC rules) for each of the last three completed fiscal years and the following measures:

•
Trevi’s cumulative total shareholder return, or TSR; and
•
Trevi’s Net Income (Loss).
    
Total Shareholder Return Amount $ 648.7 213.47 69.43
Net Income (Loss) $ (42,760,000) $ (47,910,000) $ (29,070,000.00)
PEO Name Jennifer Good Jennifer Good Jennifer Good
Measure:: 1      
Pay vs Performance Disclosure      
Name Trevi’s cumulative total shareholder return, or TSR    
Measure:: 2      
Pay vs Performance Disclosure      
Name Trevi’s Net Income (Loss).    
PEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount $ (2,968,260) $ (1,601,781) $ (851,399)
PEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 8,944,352 2,825,276 341,324
PEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 3,588,846 744,655 (120,418)
PEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 1,867,716 396,839 50,458
Non-PEO NEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount (883,890) (872,216) (212,850)
Non-PEO NEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 2,663,454 1,272,035 85,331
Non-PEO NEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 1,549,727 192,013 (87,704)
Non-PEO NEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount $ 593,699 $ 115,270 $ (11,382)