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Condensed Consolidated Statement of Stockholders’ Equity (Unaudited) - USD ($)
$ in Thousands
Total
Common Shares
Additional Paid-In Capital
Deficit
Accumulated Other Comprehensive Loss
Beginning balance (in shares) at Dec. 31, 2021   144,987,736      
Beginning balance at Dec. 31, 2021 $ 169,439 $ 1,286,636 $ 65,485 $ (1,134,347) $ (48,335)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Stock-based compensation expense 1,736   1,736    
Certain fair value adjustments to liability stock option awards 21   21    
Issuance of common shares pursuant to the Open Market Sale Agreement (in shares)   69,048      
Issuance of common shares pursuant to the Open Market Sale Agreement 268 $ 268      
Issuance of common shares pursuant to exercise of options (in shares)   5,000      
Issuance of common shares pursuant to ESPP 8 $ 18 (10)    
Issuance of common shares pursuant to ESPP (in shares)   86,501      
Issuance of common shares pursuant to ESPP 236 $ 317 (81)    
Issuance of common shares pursuant to Share Purchase Agreement   3,579,952      
Issuance of common shares pursuant to Share Purchase Agreement 10,973 $ 10,973      
Unrealized gain on available-for-sale securities (1,071)       (1,071)
Net loss (15,765)     (15,765)  
Ending balance (in shares) at Mar. 31, 2022   148,728,237      
Ending balance at Mar. 31, 2022 165,845 $ 1,298,212 67,151 (1,150,112) (49,406)
Beginning balance (in shares) at Dec. 31, 2021   144,987,736      
Beginning balance at Dec. 31, 2021 169,439 $ 1,286,636 65,485 (1,134,347) (48,335)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Net loss (29,957)        
Ending balance (in shares) at Jun. 30, 2022   148,794,262      
Ending balance at Jun. 30, 2022 153,142 $ 1,298,409 69,134 (1,164,304) (50,097)
Beginning balance (in shares) at Mar. 31, 2022   148,728,237      
Beginning balance at Mar. 31, 2022 165,845 $ 1,298,212 67,151 (1,150,112) (49,406)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Stock-based compensation expense 2,064   2,064    
Certain fair value adjustments to liability stock option awards 3   3    
Issuance of common shares pursuant to exercise of options (in shares)   66,025      
Issuance of common shares pursuant to ESPP 113 $ 197 (84)    
Unrealized gain on available-for-sale securities (691)       (691)
Net loss (14,192)     (14,192)  
Ending balance (in shares) at Jun. 30, 2022   148,794,262      
Ending balance at Jun. 30, 2022 $ 153,142 $ 1,298,409 69,134 (1,164,304) (50,097)
Beginning balance (in shares) at Dec. 31, 2022 157,455,363 157,455,363      
Beginning balance at Dec. 31, 2022 $ 136,852 $ 1,318,737 72,406 (1,203,803) (50,488)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Stock-based compensation expense 2,131   2,131    
Issuance of common shares pursuant to the Open Market Sale Agreement (in shares)   7,423,622      
Issuance of common shares pursuant to the Open Market Sale Agreement 19,862 $ 19,862      
Issuance of common shares pursuant to exercise of options (in shares)   101,356      
Issuance of common shares pursuant to ESPP 259 $ 457 (198)    
Issuance of common shares pursuant to ESPP (in shares)   151,852      
Issuance of common shares pursuant to ESPP 296 $ 397 (101)    
Unrealized gain on available-for-sale securities 854       854
Net loss (16,339)     (16,339)  
Ending balance (in shares) at Mar. 31, 2023   165,132,193      
Ending balance at Mar. 31, 2023 $ 143,915 $ 1,339,453 74,238 (1,220,142) (49,634)
Beginning balance (in shares) at Dec. 31, 2022 157,455,363 157,455,363      
Beginning balance at Dec. 31, 2022 $ 136,852 $ 1,318,737 72,406 (1,203,803) (50,488)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Net loss $ (33,433)        
Ending balance (in shares) at Jun. 30, 2023 166,922,739 166,922,739      
Ending balance at Jun. 30, 2023 $ 134,693 $ 1,344,195 77,202 (1,237,236) (49,468)
Beginning balance (in shares) at Mar. 31, 2023   165,132,193      
Beginning balance at Mar. 31, 2023 143,915 $ 1,339,453 74,238 (1,220,142) (49,634)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Stock-based compensation expense 2,964   2,964    
Issuance of common shares pursuant to the Open Market Sale Agreement (in shares)   1,790,546      
Issuance of common shares pursuant to the Open Market Sale Agreement 4,742 $ 4,742      
Unrealized gain on available-for-sale securities 166       166
Net loss $ (17,094)     (17,094)  
Ending balance (in shares) at Jun. 30, 2023 166,922,739 166,922,739      
Ending balance at Jun. 30, 2023 $ 134,693 $ 1,344,195 $ 77,202 $ (1,237,236) $ (49,468)