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v3.25.1

Collaborations, contracts and licensing agreements (Details) $ / shares in Units, $ in Thousands |  |  |  |  | 3 Months Ended | 6 Months Ended | 9 Months Ended | 28 Months Ended | 69 Months Ended |  |
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Jan. 06, 2022 USD ($) | Jan. 05, 2022 USD ($) | Jul. 02, 2019 USD ($) | Jan. 01, 2019 USD ($) | Mar. 31, 2025 USD ($) product shares | Mar. 31, 2024 USD ($) | Mar. 31, 2022 USD ($) | Jun. 30, 2016 USD ($) | Sep. 30, 2024 USD ($) | Mar. 31, 2024 USD ($) | Mar. 31, 2025 USD ($) product shares | Dec. 31, 2024 USD ($) shares | Dec. 13, 2021 USD ($) $ / shares shares
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Common shares, shares issued (in shares) | shares |  |  |  |  | 191,481,474 |  |  |  |  |  | 191,481,474 | 189,963,492 |
Deferred license revenue, current |  |  |  |  | $ 6,759 |  |  |  |  |  | $ 6,759 | $ 7,571 |
Revenues |  |  |  |  | 1,764 | $ 1,532 |  |  |  |  |  |  |
Total deferred license revenue |  |  |  |  | $ 9,622 |  |  |  |  |  | $ 9,622 |  |
Number of royalty entitlements | product |  |  |  |  | 2 |  |  |  |  |  | 2 |  |
Non Cash Royalty Revenue Related To Sale Of Future Royalties |  |  |  |  | $ 448 | 593 |  |  |  |  |  |  |
Qilu Pharmaceutical Co, LTD. |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Income taxes paid |  |  |  |  |  |  | $ 4,400 |  | $ 4,400 |  |  |  |
Common Shares | Qilu Pharmaceutical Co, LTD. |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Noncontrolling interest, ownership percentage by noncontrolling owners |  |  |  |  |  |  |  |  |  |  |  |  | 2.50%
Non-cash royalty revenue |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  | $ 448 | 593 |  |  |  |  |  |  |
Minimum |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Royalty interest, % interest |  |  |  |  | 0.75% |  |  |  |  |  |  |  |
Maximum |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Royalty interest, % interest |  |  |  |  | 1.125% |  |  |  |  |  |  |  |
Vaccitech |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Costs related to collaboration |  |  |  |  | $ 400 | 500 |  |  |  |  |  |  |
OMERS |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Gross proceeds from sale of royalty interest. before advisory fees |  |  |  | $ 20,000 |  |  |  |  |  |  |  |  |
Entitlement of royalties to be received |  |  | $ 30,000 | 30,000 |  |  |  |  |  |  |  |  |
Future royalty payments |  |  | $ 30,000 | $ 30,000 |  |  |  |  |  |  |  |  |
Non Cash Royalty Revenue Related To Sale Of Future Royalties |  |  |  |  | 400 | 600 |  |  |  |  | $ (25,300) |  |
OMERS | Minimum |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Royalty interest, % interest |  |  | 1.00% |  |  |  |  | 1.00% |  |  |  |  |
OMERS | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Royalty interest, % interest |  |  | 2.33% |  |  |  |  | 2.33% |  |  |  |  |
Arbutus Biopharma Corp |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Royalty guarantees commitments percentage |  |  | 100.00% | 100.00% |  |  |  |  |  |  |  |  |
Acuitas Therapeutics, Inc. | Revenue from collaborations and licenses |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  | 504 | 695 |  |  |  |  |  |  |
Alnylam Pharmaceuticals, Inc. | Non-cash royalty revenue |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  | 448 | 593 |  |  |  |  |  |  |
Qilu Pharmaceutical Co, LTD. |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Potential milestone payments |  |  |  |  |  |  |  |  |  |  |  |  | $ 245,000
Premium on closing stock price ($ paid) |  | $ 4,100 |  |  |  |  |  |  |  |  |  |  |
Revenue, remaining performance obligation, amount |  |  |  |  | 11,595 |  |  |  |  |  | 11,595 |  | 50,445
Recovery of direct costs |  |  |  |  | 2,000 |  |  |  |  | $ 1,973 |  |  |
Cumulative Collaboration Revenue Recognized |  |  |  |  |  |  |  |  |  | 38,850 |  |  |
Total deferred license revenue |  |  |  |  | 9,600 |  |  |  |  |  | $ 9,600 |  |
Other deferred costs, gross |  |  |  |  |  |  |  |  |  |  |  |  | $ 600
Amortization of other deferred charges |  |  |  |  | 100 | 100 |  |  |  |  |  |  |
Deferred Revenue Arrangement [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Recovery of direct costs |  |  |  |  | 2,000 |  |  |  |  | $ 1,973 |  |  |
Qilu Pharmaceutical Co, LTD. | Common Shares |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Common shares, shares issued (in shares) | shares |  |  |  |  |  |  |  |  |  |  |  |  | 3,579,952
Share price (in USD per share) | $ / shares |  |  |  |  |  |  |  |  |  |  |  |  | $ 4.19
Premium on closing stock price (as a percent) |  |  |  |  |  |  |  |  |  |  |  |  | 15.00%
Issuance of common shares pursuant to the Open Market Sale Agreement | $ 15,000 |  |  |  |  |  |  |  |  |  |  |  |
Qilu Pharmaceutical Co, LTD. | One-Time Upfront Cash Payment |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from collaborators |  | $ 40,000 |  |  |  |  |  |  |  |  |  |  |
Qilu Pharmaceutical Co, LTD. | Revenue from collaborations and licenses |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  | 812 | $ 244 |  |  |  |  |  |  |
ONPATTRO |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Royalty interest sold, annual revenue threshold of highest tier |  |  | $ 500,000 |  | $ 500,000 |  |  | $ 500,000 |  |  |  |  |

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