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Collaborations, contracts and licensing agreements (Details) $ / shares in Units, $ in Thousands					3 Months Ended			6 Months Ended	9 Months Ended	28 Months Ended	69 Months Ended
	Jan. 06, 2022 USD ($)	Jan. 05, 2022 USD ($)	Jul. 02, 2019 USD ($)	Jan. 01, 2019 USD ($)	Mar. 31, 2025 USD ($) product shares	Mar. 31, 2024 USD ($)	Mar. 31, 2022 USD ($)	Jun. 30, 2016 USD ($)	Sep. 30, 2024 USD ($)	Mar. 31, 2024 USD ($)	Mar. 31, 2025 USD ($) product shares	Dec. 31, 2024 USD ($) shares	Dec. 13, 2021 USD ($) $ / shares shares
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Common shares, shares issued (in shares) | shares					191,481,474						191,481,474	189,963,492
Deferred license revenue, current					$ 6,759						$ 6,759	$ 7,571
Revenues					1,764	$ 1,532
Total deferred license revenue					$ 9,622						$ 9,622
Number of royalty entitlements | product					2						2
Non Cash Royalty Revenue Related To Sale Of Future Royalties					$ 448	593
Qilu Pharmaceutical Co, LTD.
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Income taxes paid							$ 4,400		$ 4,400
Common Shares | Qilu Pharmaceutical Co, LTD.
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Noncontrolling interest, ownership percentage by noncontrolling owners													2.50%
Non-cash royalty revenue
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Revenues					$ 448	593
Minimum
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Royalty interest, % interest					0.75%
Maximum
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Royalty interest, % interest					1.125%
Vaccitech
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Costs related to collaboration					$ 400	500
OMERS
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Gross proceeds from sale of royalty interest. before advisory fees				$ 20,000
Entitlement of royalties to be received			$ 30,000	30,000
Future royalty payments			$ 30,000	$ 30,000
Non Cash Royalty Revenue Related To Sale Of Future Royalties					400	600					$ (25,300)
OMERS | Minimum
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Royalty interest, % interest			1.00%					1.00%
OMERS | Maximum
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Royalty interest, % interest			2.33%					2.33%
Arbutus Biopharma Corp
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Royalty guarantees commitments percentage			100.00%	100.00%
Acuitas Therapeutics, Inc. | Revenue from collaborations and licenses
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Revenues					504	695
Alnylam Pharmaceuticals, Inc. | Non-cash royalty revenue
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Revenues					448	593
Qilu Pharmaceutical Co, LTD.
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Potential milestone payments													$ 245,000
Premium on closing stock price ($ paid)		$ 4,100
Revenue, remaining performance obligation, amount					11,595						11,595		50,445
Recovery of direct costs					2,000					$ 1,973
Cumulative Collaboration Revenue Recognized										38,850
Total deferred license revenue					9,600						$ 9,600
Other deferred costs, gross													$ 600
Amortization of other deferred charges					100	100
Deferred Revenue Arrangement [Line Items]
Recovery of direct costs					2,000					$ 1,973
Qilu Pharmaceutical Co, LTD. | Common Shares
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Common shares, shares issued (in shares) | shares													3,579,952
Share price (in USD per share) | $ / shares													$ 4.19
Premium on closing stock price (as a percent)													15.00%
Issuance of common shares pursuant to the Open Market Sale Agreement	$ 15,000
Qilu Pharmaceutical Co, LTD. | One-Time Upfront Cash Payment
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Proceeds from collaborators		$ 40,000
Qilu Pharmaceutical Co, LTD. | Revenue from collaborations and licenses
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Revenues					812	$ 244
ONPATTRO
Research and Development Arrangement, Contract to Perform for Others [Line Items]
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