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Collaborations, contracts and licensing agreements (Details) $ / shares in Units, $ in Thousands					3 Months Ended			6 Months Ended		9 Months Ended	12 Months Ended	28 Months Ended	72 Months Ended
	Jan. 06, 2022 USD ($)	Jan. 05, 2022 USD ($)	Jul. 02, 2019 USD ($)	Jan. 01, 2019 USD ($)	Jun. 30, 2025 USD ($) product shares	Jun. 30, 2024 USD ($)	Mar. 31, 2022 USD ($)	Jun. 30, 2025 USD ($) product shares	Jun. 30, 2024 USD ($)	Sep. 30, 2016 USD ($)	Dec. 31, 2024 USD ($) shares	Mar. 31, 2024 USD ($)	Jun. 30, 2025 USD ($) product shares	Dec. 13, 2021 USD ($) $ / shares shares
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Common shares, shares issued (in shares) | shares					191,641,511			191,641,511			189,963,492		191,641,511
Deferred license revenue, current					$ 0			$ 0			$ 7,571		$ 0
Revenues					10,739	$ 1,726		12,503	$ 3,258
Total deferred license revenue					$ 0			$ 0					$ 0
Number of royalty entitlements | product					2			2					2
Non Cash Royalty Revenue Related To Sale Of Future Royalties								$ 974	1,164
Qilu Pharmaceutical Co, LTD.
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Income taxes paid							$ 4,400				$ 4,400
Common Shares | Qilu Pharmaceutical Co, LTD.
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Noncontrolling interest, ownership percentage by noncontrolling owners														2.50%
Non-cash royalty revenue
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Revenues					$ 526	571		$ 974	1,164
Minimum
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Royalty interest, % interest								0.75%
Maximum
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Royalty interest, % interest								1.125%
Vaccitech
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Costs related to collaboration					300	500
OMERS
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Gross proceeds from sale of royalty interest. before advisory fees				$ 20,000
Entitlement of royalties to be received			$ 30,000	30,000
Future royalty payments			$ 30,000	$ 30,000
Non Cash Royalty Revenue Related To Sale Of Future Royalties								$ 1,000	1,200				$ 25,900
OMERS | Minimum
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Royalty interest, % interest			1.00%							1.00%
OMERS | Maximum
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Royalty interest, % interest			2.33%							2.33%
Arbutus Biopharma Corp
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Royalty guarantees commitments percentage			100.00%	100.00%
Acuitas Therapeutics, Inc. | Revenue from collaborations and licenses
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Revenues					591	642		1,095	1,337
Alnylam Pharmaceuticals, Inc. | Non-cash royalty revenue
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Revenues					526	571		974	1,164
Qilu Pharmaceutical Co, LTD.
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Potential milestone payments														$ 245,000
Premium on closing stock price ($ paid)		$ 4,100
Revenue, remaining performance obligation, amount					0			0					$ 0	50,445
Recovery of direct costs												$ 0
Cumulative Collaboration Revenue Recognized												50,445
Other deferred costs, gross														$ 600
Amortization of other deferred charges						100		100
Deferred Revenue Arrangement [Line Items]
Recovery of direct costs												$ 0
Qilu Pharmaceutical Co, LTD. | Common Shares
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Common shares, shares issued (in shares) | shares														3,579,952
Share price (in USD per share) | $ / shares														$ 4.19
Premium on closing stock price (as a percent)														15.00%
Issuance of common shares pursuant to the Open Market Sale Agreement	$ 15,000
Qilu Pharmaceutical Co, LTD. | One-Time Upfront Cash Payment
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Proceeds from collaborators		$ 40,000
Qilu Pharmaceutical Co, LTD. | Revenue from collaborations and licenses
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Revenues					$ 9,622	$ 513		10,434	$ 757
Qilu Pharmaceutical Co, LTD. | Labor hours
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Revenues								500
ONPATTRO
Research and Development Arrangement, Contract to Perform for Others [Line Items]
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