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Segment Reporting | 9 Months Ended
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Sep. 30, 2025
Segment Reporting [Abstract] |
Segment Reporting Disclosure | Segment Reporting The Company has one reportable segment. The Company’s chief operating decision maker is the Chief Executive Officer and President. The accounting policies of the single segment are the same as those described in the summary of significant accounting policies. The chief operating decision maker assesses performance for the single segment and decides how to allocate resources based on net loss that also is reported on the condensed and consolidated statements of operations and comprehensive income (loss) as consolidated net loss. The chief operating decision maker uses net loss to monitor budget versus actual results and to evaluate the overall cash burn of the business.
| Three Months Ended September 30, |  | Nine Months Ended September 30,
| 2025 |  | 2024 |  | 2025 |  | 2024
| (in thousands)
Revenue | $ | 529 |  |  | $ | 1,339 |  |  | $ | 13,032 |  |  | $ | 4,597 |
Less: |  |  |  |  |  |  |
Research and development employee expense, lab supplies and overhead | 3,194 |  |  | 6,166 |  |  | 9,927 |  |  | 20,174 |
Imdusiran IM-PROVE I, II & III clinical trials expense | 1,073 |  |  | 5,031 |  |  | 4,862 |  |  | 14,430 |
AB-101-001 Phase 1a/1b clinical trial expense | 1,134 |  |  | 2,931 |  |  | 4,771 |  |  | 8,927 |
Other research and development programs expense | 377 |  |  | 145 |  |  | 675 |  |  | 1,696 |
General and administrative expense | 3,044 |  |  | 4,537 |  |  | 12,204 |  |  | 17,396 |
Restructuring expense | 98 |  |  | 3,625 |  |  | 12,636 |  |  | 3,625 |
Other segment expense (1) | 303 |  |  | 367 |  |  | 893 |  |  | 857 |
Add: |  |  |  |  |  |  |
Interest income | 952 |  |  | 1,746 |  |  | 3,191 |  |  | 5,120 |
Segment net loss | $ | (7,742) |  |  | $ | (19,717) |  |  | $ | (29,745) |  |  | $ | (57,388) |
Adjustments and reconciling items | — |  |  | — |  |  | — |  |  | — |
Consolidated net loss | $ | (7,742) |  |  | $ | (19,717) |  |  | $ | (29,745) |  |  | $ | (57,388) |
(1) Other segment expense includes the change in the fair value of contingent consideration, non-cash interest expenses and foreign currency exchange gains and losses.

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- Definition The entire disclosure for reporting segments including data and tables. Reportable segments include those that meet any of the following quantitative thresholds a) it's reported revenue, including sales to external customers and intersegment sales or transfers is 10 percent or more of the combined revenue, internal and external, of all operating segments b) the absolute amount of its reported profit or loss is 10 percent or more of the greater, in absolute amount of 1) the combined reported profit of all operating segments that did not report a loss or 2) the combined reported loss of all operating segments that did report a loss c) its assets are 10 percent or more of the combined assets of all operating segments. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 21 -Subparagraph (b) -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-21 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Topic 280 -SubTopic 10 -Name 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