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Sale of future royalties - Liability Activity (Details) - USD ($) $ in Thousands |  | 9 Months Ended | 12 Months Ended
--- | --- | --- | ---
Jul. 02, 2019 | Sep. 30, 2025 | Sep. 30, 2024 | Dec. 31, 2016
Liability Related To Sale Of Future Royalties [Roll Forward] |  |  |  |
Net liability related to sale of future royalties - beginning balance |  | $ 4,829 | $ 6,953 |
Non-cash royalty revenue |  | (1,223) | (1,736) |
Non-cash interest expense |  | 78 | 98 |
Net liability related to sale of future royalties - ending balance |  | 3,684 | 5,315 |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |
Non-cash interest expense |  | 78 | 98 |
ONPATTRO |  |  |  |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |
Royalty interest sold, annual revenue threshold of highest tier | $ 500,000 | 500,000 |  | $ 500,000
OMERS |  |  |  |
Liability Related To Sale Of Future Royalties [Roll Forward] |  |  |  |
Non-cash interest expense |  | 100 | 100 |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |  |  |  |
Non-cash interest expense |  | $ 100 | $ 100 |

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