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Sale of future royalties - Liability Activity (Details) - USD ($)
$ in Thousands
 9 Months Ended 12 Months Ended
Jul. 02, 2019
Sep. 30, 2025
Sep. 30, 2024
Dec. 31, 2016
Liability Related To Sale Of Future Royalties [Roll Forward]        
Net liability related to sale of future royalties - beginning balance   $ 4,829 $ 6,953  
Non-cash royalty revenue   (1,223) (1,736)  
Non-cash interest expense   78 98  
Net liability related to sale of future royalties - ending balance   3,684 5,315  
Research and Development Arrangement, Contract to Perform for Others [Line Items]        
Non-cash interest expense   78 98  
ONPATTRO        
Research and Development Arrangement, Contract to Perform for Others [Line Items]        
Royalty interest sold, annual revenue threshold of highest tier $ 500,000 500,000   $ 500,000
OMERS        
Liability Related To Sale Of Future Royalties [Roll Forward]        
Non-cash interest expense   100 100  
Research and Development Arrangement, Contract to Perform for Others [Line Items]        
Non-cash interest expense   $ 100 $ 100