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Collaborations, contracts and licensing agreements (Details) $ / shares in Units, $ in Thousands					3 Months Ended				9 Months Ended		12 Months Ended	72 Months Ended
	Jan. 06, 2022 USD ($)	Jan. 05, 2022 USD ($)	Jul. 02, 2019 USD ($)	Jan. 01, 2019 USD ($)	Sep. 30, 2025 USD ($) product shares	Mar. 31, 2025 USD ($)	Sep. 30, 2024 USD ($)	Mar. 31, 2022 USD ($)	Sep. 30, 2025 USD ($) product shares	Sep. 30, 2024 USD ($)	Dec. 31, 2016 USD ($)	Jun. 30, 2025 USD ($)	Dec. 31, 2024 USD ($) shares	Dec. 13, 2021 USD ($) $ / shares shares
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Common shares, shares issued (in shares) | shares					191,953,665				191,953,665				189,963,492
Deferred license revenue, current					$ 0				$ 0				$ 7,571
Number of royalty entitlements | product					2				2
Non Cash Royalty Revenue Related To Sale Of Future Royalties									$ 1,223	$ 1,736
Qilu Pharmaceutical Co, LTD.
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Income taxes paid						$ 4,400		$ 4,400
Common Shares | Qilu Pharmaceutical Co, LTD.
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Noncontrolling interest, ownership percentage by noncontrolling owners														2.50%
Minimum
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Royalty interest, % interest									0.75%
Maximum
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Royalty interest, % interest									1.125%
Vaccitech
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Costs related to collaboration					$ 400		$ 500
OMERS
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Gross proceeds from sale of royalty interest. before advisory fees				$ 20,000
Entitlement of royalties to be received			$ 30,000	30,000
Future royalty payments			$ 30,000	$ 30,000
Non Cash Royalty Revenue Related To Sale Of Future Royalties									$ 1,200	1,700		$ 26,300
OMERS | Minimum
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Royalty interest, % interest			1.00%								1.00%
OMERS | Maximum
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Royalty interest, % interest			2.33%								2.33%
Arbutus Biopharma Corp
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Royalty guarantees commitments percentage			100.00%	100.00%
Qilu Pharmaceutical Co, LTD.
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Potential milestone payments														$ 245,000
Premium on closing stock price ($ paid)		$ 4,100
Revenue, remaining performance obligation, amount														50,400
Other deferred costs, gross														$ 600
Amortization of other deferred charges							100		100
Qilu Pharmaceutical Co, LTD. | Common Shares
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Common shares, shares issued (in shares) | shares														3,579,952
Share price (in USD per share) | $ / shares														$ 4.19
Premium on closing stock price (as a percent)														15.00%
Issuance of common shares pursuant to the Open Market Sale Agreement	$ 15,000
Qilu Pharmaceutical Co, LTD. | One-Time Upfront Cash Payment
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Proceeds from collaborators		$ 40,000
Qilu Pharmaceutical Co, LTD. | Revenue from collaborations and licenses
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Deferred revenue recognized							$ 100		9,600	$ 900
Qilu Pharmaceutical Co, LTD. | Labor hours
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Deferred revenue recognized									500
ONPATTRO
Research and Development Arrangement, Contract to Perform for Others [Line Items]
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