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Collaborations, contracts and licensing agreements - Revenue from collaborations and licenses (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2025	Sep. 30, 2024	Sep. 30, 2025	Sep. 30, 2024
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Revenues	$ 529	$ 1,339	$ 13,032	$ 4,597
Revenue from collaborations and licenses | Acuitas Therapeutics, Inc.
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Revenues	280	644	1,375	1,981
Revenue from collaborations and licenses | Qilu Pharmaceutical Co, LTD.
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Revenues	0	123	10,434	880
Non-cash royalty revenue
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Revenues	249	572	1,223	1,736
Non-cash royalty revenue | Alnylam Pharmaceuticals, Inc.
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Revenues	$ 249	$ 572	$ 1,223	$ 1,736

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