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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS CHANGE IN CASH AND CASH EQUIVALENTS (USD $)
In Thousands
 6 Months Ended
Jun. 30, 2011
Jun. 30, 2010
Cash flows from operating activities:    
Net loss $ (45,477) $ (33,671)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 834 804
Accretion and amortization on investments, net 2,431 1,814
Loss on retirement/sale of property and equipment 0 53
Issuance of common stock for acquired in-process research and development 594 0
Issuance of common stock in exchange for services by non-employees 396 2,193
Stock-based compensation for employees and directors 10,166 6,120
Amortization related to 401(k) contributions 452 352
Loss on investments in licensees 503 892
Unrealized gain on fair value of derivatives (279) (230)
Changes in assets and liabilities:    
Other current and noncurrent assets 3,245 2,203
Other current and noncurrent liabilities 371 302
Translation adjustment 12 (3)
Net cash used in operating activities (26,752) (19,171)
Cash flows from investing activities:    
Restricted cash transfer (1) (1)
Purchases of property and equipment (260) (420)
Proceeds from sale of property and equipment 0 2
Purchases of marketable securities (70,765) (58,826)
Proceeds from maturities of marketable securities 83,537 70,940
Net cash provided by investing activities 12,511 11,695
Cash flows from financing activities:    
Proceeds from issuances of common stock and warrants, net of issuance costs 288 10,190
Net cash provided by financing activities 288 10,190
Net (decrease) increase in cash and cash equivalents (13,953) 2,714
Cash and cash equivalents at the beginning of the period 45,972 34,601
Cash and cash equivalents at the end of the period $ 32,019 $ 37,315