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CONSOLIDATED STATEMENTS OF CASH FLOWS (USD $) In Thousands, unless otherwise specified | 12 Months Ended
--- | ---
Dec. 31, 2013 | Dec. 31, 2012 | Dec. 31, 2011
Cash flows from operating activities: |  |  |
Net loss | $ (38,379) | $ (68,881) | $ (96,853)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation and amortization | 320 | 830 | 1,580
Accretion and amortization on investments, net | 1,322 | 2,184 | 4,422
Accretion of discount on long-term debt |  |  | 51
Loss on debt extinguishment |  |  | 1,664
(Gain) loss on sale/retirement of property and equipment, net | (831) | (142) | 5
Loss on write-downs of property and equipment | 200 | 271 | 874
Loss on sale of marketable securities |  |  | 2
Issuance of common stock in connection with acquired in-process research technology |  |  | 594
Stock-based compensation for services by non-employees | 252 | 183 | 744
Stock-based compensation for employees and directors | 4,435 | 5,311 | 15,249
Amortization related to 401(k) contributions | 458 | 726 | 709
Loss on equity method investment |  |  | 503
Unrealized loss (gain) on derivatives | 316 | (13) | (643)
Changes in assets and liabilities: |  |  |
Interest and other receivables | 188 | 646 | 401
Prepaid assets | 1,081 | 1,311 | 4,085
Deposits and other assets | (4) | 112 | (658)
Accounts payable | (2,032) | 449 | (482)
Accrued compensation and benefits | (431) | 3,548 | 944
Accrued restructuring charges | (1,878) | (1,758) | 3,730
Accrued liabilities | (1,697) | (92) | 1,038
Deferred revenue |  |  | (350)
Translation adjustment |  | 169 | (1)
Net cash used in operating activities | (36,680) | (55,146) | (62,392)
Cash flows from investing activities: |  |  |
Restricted cash transfer | (1) | (1) | (1)
Purchases of property and equipment | (3) | (862) | (612)
Proceeds from sales of property and equipment | 1,196 | 170 |
Purchases of marketable securities | (88,977) | (79,369) | (144,890)
Proceeds from sales of marketable securities |  |  | 809
Proceeds from maturities of marketable securities | 108,839 | 141,016 | 176,832
Proceeds from sale of investment in licensees |  |  | 1
Net cash provided by investing activities | 21,054 | 60,954 | 32,139
Cash flows from financing activities: |  |  |
Proceeds from issuance of long-term debt |  |  | 6,422
Repayment of long-term debt |  |  | (6,422)
Proceeds from issuance of common stock, net of issuance costs | 6,553 | 150 | 386
Net cash provided by financing activities | 6,553 | 150 | 386
Net (decrease) increase in cash and cash equivalents | (9,073) | 5,958 | (29,867)
Cash and cash equivalents, at beginning of year | 22,063 | 16,105 | 45,972
Cash and cash equivalents, at end of year | 12,990 | 22,063 | 16,105
Supplemental disclosure of cash flow information: |  |  |
Cash paid for interest |  |  | $ 37

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- Definition The cash outflow to acquire debt and equity securities not classified as either held-to-maturity securities or trading securities which would be classified as available-for-sale securities and reported at fair value, with unrealized gains and losses excluded from earnings and reported in a separate component of shareholders' equity. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Investing Activities -URI http://asc.fasb.org/extlink&oid=6516133 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=6871852&loc=d3e26853-111562 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (a),(b) -URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3213-108585 + Details
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- Definition The cash outflow associated with the acquisition of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale; includes cash outflows to pay for construction of self-constructed assets. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Investing Activities -URI http://asc.fasb.org/extlink&oid=6516133 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3213-108585 + Details
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- Definition The cash inflow from the additional capital contribution to the entity. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3255-108585 + Details
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