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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (USD $) | Total | Common Stock | Additional Paid-In Capital | Accumulated Deficit | Accumulated Other Comprehensive Income (Loss)
--- | --- | --- | --- | --- | ---
Balances at Dec. 31, 2010 | $ 192,735,000 | $ 123,000 | $ 881,358,000 | $ (688,650,000) | $ (96,000)
Balances (in shares) at Dec. 31, 2010 |  | 122,616,729 |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Net loss | (96,853,000) |  |  | (96,853,000) |
Other comprehensive income (loss) | 5,000 |  |  |  | 5,000
Issuance of common stock in connection with acquired in-process research technology | 28,094,000 | 5,000 | 28,089,000 |  |
Issuance of common stock in connection with acquired in-process research technology (in shares) |  | 5,261,144 |  |  |
Stock-based compensation related to issuance of common stock and options in exchange for services | 715,000 |  | 715,000 |  |
Stock-based compensation related to issuance of common stock and options in exchange for services (in shares) |  | 180,954 |  |  |
Issuance of common stock under equity plans, net of cancellations of non-vested restricted stock | 3,263,000 | 3,000 | 3,260,000 |  |
Issuance of common stock under equity plans, net of cancellations of non-vested restricted stock (in shares) |  | 3,031,121 |  |  |
Stock-based compensation for equity-based awards to employees and directors | 15,249,000 |  | 15,249,000 |  |
Debt discount in connection with warrant issuances | 1,715,000 |  | 1,715,000 |  |
401(k) contribution | 1,680,000 |  | 1,680,000 |  |
401(k) contribution (in shares) |  | 353,200 |  |  |
Balances at Dec. 31, 2011 | 146,603,000 | 131,000 | 932,066,000 | (785,503,000) | (91,000)
Balances (in shares) at Dec. 31, 2011 |  | 131,443,148 |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Net loss | (68,881,000) |  |  | (68,881,000) |
Other comprehensive income (loss) | 131,000 |  |  |  | 131,000
Stock-based compensation related to issuance of common stock and options in exchange for services | 135,000 |  | 135,000 |  |
Stock-based compensation related to issuance of common stock and options in exchange for services (in shares) |  | 170,298 |  |  |
Cancellations of non-vested restricted stock under equity plans, net of issuances of common stock | 267,000 | (2,000) | 269,000 |  |
Cancellations of non-vested restricted stock under equity plans, net of issuances of common stock (in shares) |  | (2,592,375) |  |  |
Stock-based compensation for equity-based awards to employees and directors | 5,311,000 |  | 5,311,000 |  |
401(k) contribution | 2,087,000 | 1,000 | 2,086,000 |  |
401(k) contribution (in shares) |  | 1,221,624 |  |  |
Balances at Dec. 31, 2012 | 85,653,000 | 130,000 | 939,867,000 | (854,384,000) | 40,000
Balances (in shares) at Dec. 31, 2012 | 130,242,695 | 130,242,695 |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Net loss | (38,379,000) |  |  | (38,379,000) |
Other comprehensive income (loss) | (54,000) |  |  |  | (54,000)
Stock-based compensation related to issuance of common stock and options in exchange for services | 252,000 |  | 252,000 |  |
Stock-based compensation related to issuance of common stock and options in exchange for services (in shares) |  | 66,853 |  |  |
Cancellations of non-vested restricted stock under equity plans, net of issuances of common stock | 6,553,000 |  | 6,553,000 |  |
Cancellations of non-vested restricted stock under equity plans, net of issuances of common stock (in shares) |  | (388,056) |  |  |
Stock-based compensation for equity-based awards to employees and directors | 4,435,000 |  | 4,435,000 |  |
401(k) contribution | 1,297,000 | 1,000 | 1,296,000 |  |
401(k) contribution (in shares) |  | 756,457 |  |  |
Balances at Dec. 31, 2013 | $ 59,757,000 | $ 131,000 | $ 952,403,000 | $ (892,763,000) | $ (14,000)
Balances (in shares) at Dec. 31, 2013 | 130,677,949 | 130,677,949 |  |  |

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