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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (USD $)
Total
Common Stock
Additional Paid-In Capital
Accumulated Deficit
Accumulated Other Comprehensive Income (Loss)
Balances at Dec. 31, 2010 $ 192,735,000 $ 123,000 $ 881,358,000 $ (688,650,000) $ (96,000)
Balances (in shares) at Dec. 31, 2010   122,616,729      
Increase (Decrease) in Stockholders' Equity          
Net loss (96,853,000)     (96,853,000)  
Other comprehensive income (loss) 5,000       5,000
Issuance of common stock in connection with acquired in-process research technology 28,094,000 5,000 28,089,000    
Issuance of common stock in connection with acquired in-process research technology (in shares)   5,261,144      
Stock-based compensation related to issuance of common stock and options in exchange for services 715,000   715,000    
Stock-based compensation related to issuance of common stock and options in exchange for services (in shares)   180,954      
Issuance of common stock under equity plans, net of cancellations of non-vested restricted stock 3,263,000 3,000 3,260,000    
Issuance of common stock under equity plans, net of cancellations of non-vested restricted stock (in shares)   3,031,121      
Stock-based compensation for equity-based awards to employees and directors 15,249,000   15,249,000    
Debt discount in connection with warrant issuances 1,715,000   1,715,000    
401(k) contribution 1,680,000   1,680,000    
401(k) contribution (in shares)   353,200      
Balances at Dec. 31, 2011 146,603,000 131,000 932,066,000 (785,503,000) (91,000)
Balances (in shares) at Dec. 31, 2011   131,443,148      
Increase (Decrease) in Stockholders' Equity          
Net loss (68,881,000)     (68,881,000)  
Other comprehensive income (loss) 131,000       131,000
Stock-based compensation related to issuance of common stock and options in exchange for services 135,000   135,000    
Stock-based compensation related to issuance of common stock and options in exchange for services (in shares)   170,298      
Cancellations of non-vested restricted stock under equity plans, net of issuances of common stock 267,000 (2,000) 269,000    
Cancellations of non-vested restricted stock under equity plans, net of issuances of common stock (in shares)   (2,592,375)      
Stock-based compensation for equity-based awards to employees and directors 5,311,000   5,311,000    
401(k) contribution 2,087,000 1,000 2,086,000    
401(k) contribution (in shares)   1,221,624      
Balances at Dec. 31, 2012 85,653,000 130,000 939,867,000 (854,384,000) 40,000
Balances (in shares) at Dec. 31, 2012 130,242,695 130,242,695      
Increase (Decrease) in Stockholders' Equity          
Net loss (38,379,000)     (38,379,000)  
Other comprehensive income (loss) (54,000)       (54,000)
Stock-based compensation related to issuance of common stock and options in exchange for services 252,000   252,000    
Stock-based compensation related to issuance of common stock and options in exchange for services (in shares)   66,853      
Cancellations of non-vested restricted stock under equity plans, net of issuances of common stock 6,553,000   6,553,000    
Cancellations of non-vested restricted stock under equity plans, net of issuances of common stock (in shares)   (388,056)      
Stock-based compensation for equity-based awards to employees and directors 4,435,000   4,435,000    
401(k) contribution 1,297,000 1,000 1,296,000    
401(k) contribution (in shares)   756,457      
Balances at Dec. 31, 2013 $ 59,757,000 $ 131,000 $ 952,403,000 $ (892,763,000) $ (14,000)
Balances (in shares) at Dec. 31, 2013 130,677,949 130,677,949