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CONDENSED STATEMENTS OF CASH FLOWS CHANGE IN CASH AND CASH EQUIVALENTS (USD $)
In Thousands, unless otherwise specified
 6 Months Ended
Jun. 30, 2014
Jun. 30, 2013
Cash flows from operating activities:    
Net loss $ (17,174) $ (20,844)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 29 264
Accretion and amortization on investments, net 1,456 647
Loss (gain) on retirement/sales of property and equipment, net 3 (116)
Loss on write-downs of property and equipment   200
Stock-based compensation for services by non-employees 149 53
Stock-based compensation for employees and directors 3,743 2,234
Amortization related to 401(k) contributions 76 465
Unrealized gain on derivatives (77) (1)
Changes in assets and liabilities:    
Other current and noncurrent assets (419) 1,248
Other current liabilities (2,441) (8,304)
Net cash used in operating activities (14,655) (24,154)
Cash flows from investing activities:    
Restricted cash transfer   (1)
Purchases of property and equipment   (56)
Proceeds from sales of property and equipment   116
Purchases of marketable securities (128,203) (40,110)
Proceeds from maturities of marketable securities 41,663 50,916
Net cash (used in) provided by investing activities (86,540) 10,865
Cash flows from financing activities:    
Proceeds from issuance of common stock, net of issuance costs 97,725 60
Net cash provided by financing activities 97,725 60
Net decrease in cash and cash equivalents (3,470) (13,229)
Cash and cash equivalents at the beginning of the period 12,990 22,063
Cash and cash equivalents at the end of the period $ 9,520 $ 8,834