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CONDENSED STATEMENTS OF CASH FLOWS CHANGE IN CASH AND CASH EQUIVALENTS (USD $)
In Thousands, unless otherwise specified
 9 Months Ended
Sep. 30, 2014
Sep. 30, 2013
Cash flows from operating activities:    
Net loss $ (26,723) $ (29,098)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 38 357
Accretion and amortization on investments, net 2,221 948
Loss (gain) on retirement/sales of property and equipment, net 3 (759)
Loss on write-downs of property and equipment   200
Stock-based compensation for services by non-employees 172 136
Stock-based compensation for employees and directors 5,752 3,456
Amortization related to 401(k) contributions 99 449
Unrealized (gain) loss on derivatives (366) 207
Changes in assets and liabilities:    
Other current and noncurrent assets (484) 904
Other current liabilities 161 (6,679)
Net cash used in operating activities (19,127) (29,879)
Cash flows from investing activities:    
Restricted cash transfer 530 (1)
Purchases of property and equipment (12) (56)
Proceeds from sales of property and equipment   1,116
Purchases of marketable securities (159,172) (57,446)
Proceeds from sales of marketable securities 4,513  
Proceeds from maturities of marketable securities 70,048 73,301
Net cash (used in) provided by investing activities (84,093) 16,914
Cash flows from financing activities:    
Proceeds from issuance of common stock, net of issuance costs 97,830 493
Net cash provided by financing activities 97,830 493
Net decrease in cash and cash equivalents (5,390) (12,472)
Cash and cash equivalents at the beginning of period 12,990 22,063
Cash and cash equivalents at the end of the period $ 7,600 $ 9,591