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STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2015 | Dec. 31, 2014 | Dec. 31, 2013
Cash flows from operating activities: |  |  |
Net income (loss) | $ 46 | $ (35,670) | $ (38,379)
Adjustments to reconcile net income (loss) to net cash (used in) provided by operating activities: |  |  |
Depreciation and amortization | 56 | 47 | 320
Accretion and amortization on investments, net | 2,098 | 2,889 | 1,322
Loss (gain) on retirement/sales of property and equipment, net |  | 3 | (831)
Loss on write-downs of property and equipment |  |  | 200
Loss on sales of marketable securities | 1 |  |
Stock-based compensation for services by non-employees | 364 | 253 | 252
Stock-based compensation for employees and directors | 8,397 | 7,658 | 4,435
Amortization related to 401(k) contributions | 161 | 111 | 458
Unrealized (gain) loss on derivatives | (16) | (351) | 316
Changes in assets and liabilities: |  |  |
Interest and other receivables | (243) | (399) | 188
Prepaid assets | 89 | (72) | 1,081
Deposits and other assets |  | 5 | (4)
Accounts payable | (873) | (364) | (2,032)
Accrued compensation and benefits | (1,239) | 580 | (431)
Accrued collaboration charges | 2,328 |  |
Accrued restructuring charges | 52 | (94) | (1,878)
Accrued liabilities | (417) | (246) | (1,697)
Deferred revenue | (35,000) | 35,000 |
Net cash (used in) provided by operating activities | (24,196) | 9,350 | (36,680)
Cash flows from investing activities: |  |  |
Restricted cash transfer | (1) | 529 | (1)
Purchases of property and equipment | (90) | (131) | (3)
Proceeds from sales of property and equipment |  |  | 1,196
Purchases of marketable securities | (206,459) | (190,263) | (88,977)
Proceeds from sales/calls of marketable securities | 4,242 | 10,549 |
Proceeds from maturities of marketable securities | 202,381 | 101,412 | 108,839
Net cash provided by (used in) investing activities | 73 | (77,904) | 21,054
Cash flows from financing activities: |  |  |
Proceeds from issuance of common stock, net of issuance costs | 2,575 | 98,360 | 6,553
Net cash provided by financing activities | 2,575 | 98,360 | 6,553
Net (decrease) increase in cash and cash equivalents | (21,548) | 29,806 | (9,073)
Cash and cash equivalents, at beginning of year | 42,796 | 12,990 | 22,063
Cash and cash equivalents, at end of year | $ 21,248 | $ 42,796 | $ 12,990

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- Definition The sum of the periodic adjustments of the differences between securities' face values and purchase prices that are charged against earnings. This is called accretion if the security was purchased at a discount and amortization if it was purchased at premium. As a noncash item, this element is an adjustment to net income when calculating cash provided by or used in operations using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -URI http://asc.fasb.org/extlink&oid=56944662&loc=d3e3602-108585 + Details
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- Definition This item represents the difference between the gross realized gains and losses realized on the sale of debt or equity securities categorized neither as held-to-maturity nor trading securities. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 7 -URI http://asc.fasb.org/extlink&oid=49167202&loc=d3e26805-111562 + Details
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- Definition The cash inflow associated with maturities (principal being due), prepayments and calls (requests of early payments) on securities not classified as either held-to-maturity securities or trading securities which are classified as available-for-sale securities. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (a),(b) -URI http://asc.fasb.org/extlink&oid=56944662&loc=d3e3179-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=49167202&loc=d3e26853-111562 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Investing Activities -URI http://asc.fasb.org/extlink&oid=6516133 + Details
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- Definition The cash inflow associated with the sale of debt securities classified as available-for-sale securities. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=49167202&loc=d3e26853-111562 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=56944662&loc=d3e3179-108585 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Investing Activities -URI http://asc.fasb.org/extlink&oid=6516133 + Details
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- Definition The cash inflow from the sale of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=56944662&loc=d3e3179-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Investing Activities -URI http://asc.fasb.org/extlink&oid=6516133 + Details
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- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=56944662&loc=d3e3602-108585 + Details
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- Definition The net change in the difference between the fair value and the carrying value, or in the comparative fair values, of derivative instruments, including options, swaps, futures, and forward contracts, held at each balance sheet date, that was included in earnings for the period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=56944662&loc=d3e3602-108585 + Details
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