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STATEMENTS OF OPERATIONS - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2015 | Dec. 31, 2014 | Dec. 31, 2013
Revenues: |  |  |
Collaboration revenue | $ 35,000,000 |  |
License fees and royalties | 1,371,000 | $ 1,153,000 | $ 1,283,000
Total revenues | 36,371,000 | 1,153,000 | 1,283,000
Operating expenses: |  |  |
Research and development | 17,831,000 | 20,707,000 | 23,155,000
Restructuring charges | 1,306,000 |  | 1,462,000
General and administrative | 17,793,000 | 16,758,000 | 15,624,000
Total operating expenses | 36,930,000 | 37,465,000 | 40,241,000
Loss from operations | (559,000) | (36,312,000) | (38,958,000)
Unrealized gain (loss) on derivatives | 16,000 | 351,000 | (316,000)
Interest and other income | 677,000 | 373,000 | 951,000
Interest and other expense | (88,000) | (82,000) | (56,000)
Net income (loss) | $ 46,000 | $ (35,670,000) | $ (38,379,000)
Net income (loss) per share: |  |  |
Basic (in dollars per share) | $ 0.00 | $ (0.23) | $ (0.30)
Diluted (in dollars per share) | $ 0.00 | $ (0.23) | $ (0.30)
Shares used in computing net income (loss) per share: |  |  |
Basic (in shares) | 158,036,162 | 153,540,341 | 128,380,800
Diluted (in shares) | 162,663,894 | 153,540,341 | 128,380,800

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