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CONDENSED STATEMENTS OF OPERATIONS - USD ($)
 3 Months Ended
Mar. 31, 2016
Mar. 31, 2015
Revenues:    
License fees and royalties $ 749,000 $ 537,000
Operating expenses:    
Research and development 5,033,000 4,987,000
Restructuring charges   406,000
General and administrative 4,793,000 4,600,000
Total operating expenses 9,826,000 9,993,000
Loss from operations (9,077,000) (9,456,000)
Unrealized gain on derivatives   16,000
Interest and other income 256,000 149,000
Interest and other expense (21,000) (24,000)
Net loss $ (8,842,000) $ (9,315,000)
Basic and diluted net loss per share (in dollars per share) $ (0.06) $ (0.06)
Shares used in computing basic and diluted net loss per share (in shares) 158,896,038 157,547,568