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CONDENSED STATEMENTS OF OPERATIONS - USD ($)
 3 Months Ended 6 Months Ended
Jun. 30, 2016
Jun. 30, 2015
Jun. 30, 2016
Jun. 30, 2015
Revenues:        
License fees and royalties $ 211,000 $ 251,000 $ 960,000 $ 788,000
Operating expenses:        
Research and development 4,575,000 4,812,000 9,608,000 9,799,000
Restructuring charges   941,000   1,347,000
General and administrative 4,547,000 3,977,000 9,340,000 8,577,000
Total operating expenses 9,122,000 9,730,000 18,948,000 19,723,000
Loss from operations (8,911,000) (9,479,000) (17,988,000) (18,935,000)
Unrealized gain on derivatives       16,000
Interest and other income 293,000 145,000 549,000 294,000
Interest and other expense (19,000) (22,000) (40,000) (46,000)
Net loss $ (8,637,000) $ (9,356,000) $ (17,479,000) $ (18,671,000)
Basic and diluted net loss per share (in dollars per share) $ (0.05) $ (0.06) $ (0.11) $ (0.12)
Shares used in computing basic and diluted net loss per share (in shares) 158,998,931 158,066,910 158,947,485 157,807,239