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CONDENSED STATEMENTS OF CASH FLOWS CHANGE IN CASH AND CASH EQUIVALENTS - USD ($)
$ in Thousands
 6 Months Ended
Jun. 30, 2016
Jun. 30, 2015
Cash flows from operating activities:    
Net loss $ (17,479) $ (18,671)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 42 22
Accretion and amortization on investments, net 439 1,176
Stock-based compensation for services by non-employees 95 179
Stock-based compensation for employees and directors 4,136 4,389
Amortization related to 401(k) contributions 57 158
Unrealized gain on derivatives   (16)
Changes in assets and liabilities:    
Other current assets 1,019 (221)
Other current liabilities 477 (1,056)
Net cash used in operating activities (11,214) (14,040)
Cash flows from investing activities:    
Purchases of property and equipment (26)  
Purchases of marketable securities (74,110) (109,090)
Proceeds from maturities of marketable securities 71,234 94,577
Net cash used in investing activities (2,902) (14,513)
Cash flows from financing activities:    
Proceeds from issuance of common stock, net of issuance costs 1,067 1,555
Net cash provided by financing activities 1,067 1,555
Net decrease in cash and cash equivalents (13,049) (26,998)
Cash and cash equivalents at the beginning of the period 21,248 42,796
Cash and cash equivalents at the end of the period 8,199 15,798
Supplemental Disclosure of Non-Cash Investing Activities:    
Net unrealized gain on marketable securities $ 303 $ 34