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STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Cash flows from operating activities: |  |  |
Net (loss) income | $ (29,537) | $ 46 | $ (35,670)
Adjustments to reconcile net (loss) income to net cash (used in) provided by operating activities: |  |  |
Depreciation and amortization | 81 | 56 | 47
Accretion and amortization on investments, net | 552 | 2,098 | 2,889
(Gain) loss on sales/retirement of property and equipment | (16) |  | 3
Loss on sales of marketable securities |  | 1 |
Stock-based compensation for services by non-employees | 156 | 364 | 253
Stock-based compensation for employees and directors | 8,245 | 8,397 | 7,658
Amortization related to 401(k) contributions | 61 | 161 | 111
Unrealized gain on derivatives |  | (16) | (351)
Changes in assets and liabilities: |  |  |
Interest and other receivables | 731 | (243) | (399)
Prepaid assets | 123 | 89 | (72)
Deposits and other assets |  |  | 5
Accounts payable | 65 | (873) | (364)
Accrued compensation and benefits | (183) | (1,187) | 486
Accrued collaboration charges | 1,039 | 2,328 |
Accrued liabilities | 314 | (417) | (246)
Deferred revenue |  | (35,000) | 35,000
Net cash (used in) provided by operating activities | (18,369) | (24,196) | 9,350
Cash flows from investing activities: |  |  |
Restricted cash transfer | (1) | (1) | 529
Purchases of property and equipment | (57) | (90) | (131)
Proceeds from sales of property and equipment | 16 |  |
Purchases of marketable securities | (129,250) | (206,459) | (190,263)
Proceeds from sales/calls of marketable securities |  | 4,242 | 10,549
Proceeds from maturities of marketable securities | 138,054 | 202,381 | 101,412
Net cash provided by (used in) investing activities | 8,762 | 73 | (77,904)
Cash flows from financing activities: |  |  |
Proceeds from issuance of common stock, net of issuance costs | 1,169 | 2,575 | 98,360
Net cash provided by financing activities | 1,169 | 2,575 | 98,360
Net (decrease) increase in cash and cash equivalents | (8,438) | (21,548) | 29,806
Cash and cash equivalents, at beginning of year | 21,248 | 42,796 | 12,990
Cash and cash equivalents, at end of year | $ 12,810 | $ 21,248 | $ 42,796

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- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3602-108585 + Details
Name: | us-gaap_ShareBasedCompensation
Namespace Prefix: | us-gaap_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | duration

X
- Definition The net change in the difference between the fair value and the carrying value, or in the comparative fair values, of derivative instruments, including options, swaps, futures, and forward contracts, held at each balance sheet date, that was included in earnings for the period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3602-108585 + Details
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Namespace Prefix: | us-gaap_
Data Type: | xbrli:monetaryItemType
Balance Type: | credit
Period Type: | duration