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STOCKHOLDERS' EQUITY (Tables)

12 Months Ended

Dec. 31, 2016

STOCKHOLDERS' EQUITY

Schedule of aggregate option and award activity

Outstanding Options

Shares Available For Grant

Number of Shares

Weighted Average Exercise Price Per Share

Weighted Average Remaining Contractual Life (In years)

Aggregate Intrinsic Value (In thousands)

Balance at December 31, 2015

12,054,916

17,205,683

$3.29

Options granted

(2,834,000

)

2,834,000

$2.56

Awards granted

(21,541

)

—

$   —

Options exercised

—

(328,486

)

$1.50

Options cancelled/forfeited

371,160

(585,910

)

$5.34

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Balance at December 31, 2016

9,570,535

19,125,287

$3.15

6.65

$3,816

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Options exercisable at December 31, 2016

14,074,457

$2.99

6.05

$3,718

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Options fully vested and expected to vest at December 31, 2016

18,694,300

$3.14

6.60

$3,815

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Schedule of information about stock options outstanding by exercise price range

        Information about stock options outstanding as of December 31, 2016 is as follows:

		Options Outstanding
Exercise Price Range		Number of Shares			Weighted Average Exercise Price Per Share		Weighted Average Remaining Contractual Life (In years)
$1.10 - $1.51			5,668,162		$1.45		5.89
$1.55 - $2.54			5,017,031		$2.27		7.25
$2.74 - $5.01			6,347,008		$4.55		7.28
$5.09 - $9.32			2,093,086		$5.59		5.36
​	​	​	​	​	​	​	​
$1.10 - $9.32			19,125,287		$3.15		6.65
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Schedule of aggregate restricted stock activity

		Number of Shares			Weighted Average Grant Date Fair Value Per Share		Weighted Average Remaining Contractual Term (In years)
Non-vested restricted stock at December 31, 2015			500		$4.65		0.10
Granted			21,541		$2.44
Vested			(22,041	)	$2.49
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Non-vested restricted stock at December 31, 2016			—		$—		—
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Summary of allocation of stock-based compensation expense related to share-based payment awards

		Year Ended December 31,
(In thousands)		2016			2015			2014
Research and development		$	1,275		$	2,139		$	2,545
Restructuring charges			—			307			—
General and administrative			6,970			5,951			5,113
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Stock-based compensation expense included in operating expenses		$	8,245		$	8,397		$	7,658
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Schedule of assumptions used to estimate the fair value of stock options granted

		2016		2015		2014
Dividend yield		0%		0%		0%
Expected volatility range		0.888 to 0.890		0.874 to 0.884		0.898 to 0.922
Risk-free interest rate range		1.21% to 1.38%		1.68% to 1.71%		1.64% to 1.92%
Expected term		5.5 yrs		5.5 yrs		5.5 yrs

Schedule of assumptions used to estimate the fair value of employee stock purchases under the purchase plan

		2016		2015		2014
Dividend yield		0%		0%		0%
Expected volatility range		0.641 to 0.684		0.654 to 1.392		0.835 to 1.666
Risk-free interest rate range		0.28% to 0.45%		0.11% to 0.28%		0.06% to 0.15%
Expected term range		6 mos to 12 mos		6 mos to 12 mos		6 mos to 12 mos

Schedule of common stock reserved for future issuance

        Common stock reserved for future issuance as of December 31, 2016 is as follows:

Outstanding stock options			19,125,287
Options and awards available for grant			9,570,535
Employee stock purchase plan			915,115
Warrant outstanding			537,893
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Total			30,148,830
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